Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach

Autor: Avgi E. Apostolakou, Xhuliana K. Sula, Katerina C. Nastou, Georgia I. Nasi, Vassiliki A. Iconomidou

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Alzheimer disease (AD) is a neurodegenerative disorder with an –as of yet– unclear etiology and pathogenesis. Research to unveil disease processes underlying AD often relies on the use of neurodegenerative disease model organisms, such a

Externí odkaz: https://doaj.org/article/e1fe35932ecc455c9f0eb345f3234039

Analysis of Single-Nucleotide Polymorphisms in Human Voltage-Gated Ion Channels

Autor: Stavros J. Hamodrakas, Michail A. Batskinis, Katerina C. Nastou, Vassiliki A. Iconomidou, Zoi I. Litou

Publikováno v: Journal of Proteome Research. 18:2310-2320

Voltage-gated ion channels (VGICs) are one of the largest groups of transmembrane proteins. Due to their major role in the generation and propagation of electrical signals, VGICs are considered important from a medical viewpoint, and their dysfunctio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0dfbcf178e2047e4e5597b093c990a
https://doi.org/10.1021/acs.jproteome.9b00121

The STRING database in 2021:customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets

Autor: Christian von Mering, David Lyon, Rebecca Kirsch, Katerina C. Nastou, Peer Bork, Marc Legeay, Tao Fang, Sampo Pyysalo, Annika L. Gable, Nadezhda Tsankova Doncheva, Damian Szklarczyk, Lars Juhl Jensen

Publikováno v: Szklarczyk, D, Gable, A L, Nastou, K C, Lyon, D, Kirsch, R, Pyysalo, S, Doncheva, N T, Legeay, M, Fang, T, Bork, P, Jensen, L J & von Mering, C 2021, ' The STRING database in 2021 : customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets ', Nucleic Acids Symposium Series, vol. 49, no. D1, pp. D605-D612 . https://doi.org/10.1093/nar/gkaa1074
Nucleic Acids Research

Cellular life depends on a complex web of functional associations between biomolecules. Among these associations, protein–protein interactions are particularly important due to their versatility, specificity and adaptability. The STRING database ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c411c278e49bb03584f143e2360936
https://curis.ku.dk/portal/da/publications/the-string-database-in-2021(0a4ddb10-9fd9-42b2-99db-4406d1c6c7b7).html

ANTISOMA: A Computational Pipeline for the Reduction of the Aggregation Propensity of Monoclonal Antibodies

Autor: Eleftheria G Karataraki, Nikos C. Papandreou, Katerina C. Nastou, Vassiliki A. Iconomidou, Stavros J. Hamodrakas, Ilias Maglogiannis, Anna-Isavella G Rerra, Vassiliki P Grimanelli

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9783030326210

Monoclonal antibodies (mAbs) constitute a promising class of therapeutics, since ca. 25% of all biotech drugs in development are mAbs. Even though their therapeutic value is now well established, human- and murine-derived mAbs do have deficiencies, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::922e3cb75394bfbefe267c7a2fa3944a
https://doi.org/10.1007/978-3-030-32622-7_34

Visualization and Analysis of the Interaction Network of Proteins Associated with Blood-cell targeting Autoimmune Diseases

Autor: Ourania E. Tsitsilonis, Vassiliki A. Iconomidou, Athina I. Amanatidou, Katerina C. Nastou

Blood-cell targeting Autoimmune Diseases (BLADs) are complex diseases that affect blood cell formation or prevent blood cell production. Since these clinical conditions are gathering growing attention, experimental approaches are being used to invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889e7b90c75cf4236959903adeddb6c6
https://doi.org/10.1101/763672