Evaluating the Contribution of Cell Type–Specific Alternative Splicing to Variation in Lipid Levels

Autor: Katerina A.B. Gawronski, William P. Bone, YoSon Park, Evanthia E. Pashos, Brandon M. Wenz, Max F. Dudek, Xiao Wang, Wenli Yang, Daniel J. Rader, Kiran Musunuru, Benjamin F. Voight, Christopher D. Brown

Publikováno v: Circulation: Genomic and Precision Medicine.

Background: Genome-wide association studies have identified hundreds of loci associated with lipid levels. However, the genetic mechanisms underlying most of these loci are not well-understood. Recent work indicates that changes in the abundance of a

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https://doi.org/10.1161/circgen.120.003249

Evaluating the contribution of cell-type specific alternative splicing to variation in lipid levels

Autor: Kiran Musunuru, Katerina A.B. Gawronski, William P. Bone, Daniel J. Rader, YoSon Park, Xiao Wang, Evanthia E. Pashos, Christopher D. Brown, Benjamin F. Voight, Wenli Yang

BackgroundGenome-wide association studies have identified 150+ loci associated with lipid levels. However, the genetic mechanisms underlying most of these loci are not well-understood. Recent work indicates that changes in the abundance of alternativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48201a5d97bc820a0a355cb25e0ba4b
https://doi.org/10.1101/659326

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

Autor: Lucy Bowes, Richard Burns, Alex Hatzimanolis, Gonneke Willemsen, Martin A. Kennedy, Kathryn J. Lester, Katerina A.B. Gawronski, Udo Dannlowski, Alison Goate, Carolyn Coffey, Matthias Nauck, David Stacey, Ricardo Araya, Frank Bellivier, Cecilia Åslund, Catherine Toben, Catharine Jawahar, Karen Ritchie, Emilie Olié, Gyorgy Bagdy, Nicholas G. Martin, Robert Culverhouse, Isabelle Jaussent, Peter Petschner, Eric O. Johnson, Nancy L. Saccone, Sandra Villafuerte, Mohamed Lajnef, John I. Nurnberger, Volker Arolt, Laura Mandelli, Philippe Courtet, Henry Völzke, Yinjiao Ma, Craig A. Olsson, Y. Tian, Bernhard T. Baune, Keriann Little, Wouter J. Peyrot, Nicholas W.J. Wainwright, Helen L. Fisher, Brenda W.J.H. Penninx, Manfred Laucht, E.J.C. de Geus, Jan Smit, Sébastien Guillaume, J. M. Scheid, S Van der Auwera, Christian Schwahn, Hans-Jörgen Grabe, Kent W. Nilsson, Xenia Gonda, Dana A. Glei, Gabriella Juhasz, Bruno Etain, C. Holzman, Maxine Weinstein, Thalia C. Eley, Kaarin J. Anstey, Marco Sarchiapone, John Francis William Deakin, Naomi Breslau, P. G. Surtees, John Kramer, J-J Hottenga, Enda M. Byrne, Marcus R. Munafò, Christine Jennen-Steinmetz, Laura J. Bierut, Albertine J. Oldehinkel, Noreen Goldman, Dorret I. Boomsma, Simon Easteal, Margit Burmeister, John Horwood, George C Patton, Tobias Banaschewski, David M. Fergusson, Amy C. Horton, Mary A. Whooley, J. C. Wang, Esther Nederhof, H. M. Zu Schwabedissen, Grant C.B. Sinnamon, Christian Otte, Sarah Cohen-Woods, Ian M. Anderson, William L. Coventry, Tracy Air, Christel M. Middeldorp, Nicholas C. Stefanis, Alessandro Serretti, Johan Ormel

Publikováno v: Culverhouse, R C, Saccone, N L, Horton, A C, Ma, Y, Anstey, K J, Banaschewski, T, Burmeister, M, Cohen-Woods, S, Etain, B, Fisher, H L, Goldman, N, Guillaume, S, Horwood, J, Juhasz, G, Lester, K J, Mandelli, L, Middeldorp, C M, Olié, E, Villafuerte, S, Air, T M, Araya, R, Bowes, L, Burns, M R, Byrne, E M, Coffey, J C, Coventry, W L, Gawronski, K A B, Glei, D, Hatzimanolis, A, Hottenga, J-J, Jaussent, I, Jawahar, C, Jennen-Steinmetz, C, Kramer, J R, Lajnef, M, Little, K, Meyer zu Schwabedissen, H, Nauck, M, Nederhof, E, Petschner, P, Peyrot, W J, Schwahn, C, Sinnamon, G, Stacey, D, Tian, Y, Toben, C, Van der Auwera, S, Wainwright, N W, Wang, J-C, Willemsen, G, Anderson, I M, Arolt, V, Åslund, C, Bagdy, G, Baune, B T, Bellivier, F, Boomsma, D I, Courtet, P, Dannlowski, U, de Geus, E J C, Deakin, J F W, Easteal, S, Eley, T C, Fergusson, D M, Goate, A M, Gonda, X, Grabe, H J, Holzman, C, Johnson, E O, Kennedy, D M, Laucht, M, Martin, N G, Munafò, M R, Nilsson, K W, Oldehinkel, A J, Olsson, C A, Ormel, J, Otte, C, Patton, G C, Penninx, B W J H, Ritchie, K, Sarchiapone, M, Scheid, J M, Serretti, A, Smit, J H, Stefanis, N C, Surtees, P G, Völzke, H, Weinstein, M, Whooley, M A, Nurnberger, J I, Breslau, N & Bierut, L J 2018, ' Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression ', Molecular Psychiatry, vol. 23, no. 1, pp. 133-142 . https://doi.org/10.1038/mp.2017.44
Culverhouse, R C, Saccone, N L, Horton, A C, Ma, Y, Anstey, K J, Banaschewski, T, Burmeister, M, Cohen-Woods, S, Etain, B, Fisher, H L, Goldman, N, Guillaume, S, Horwood, J, Juhasz, G, Lester, K J, Mandelli, L, Middeldorp, C M, Olié, E, Villafuerte, S, Air, T M, Araya, R, Bowes, L, Burns, R, Byrne, E M, Coffey, C, Coventry, W L, Gawronski, K A B, Glei, D, Hatzimanolis, A, Hottenga, J-J, Jaussent, I, Jawahar, C, Jennen-Steinmetz, C, Kramer, J R, Lajnef, M, Little, K, Zu Schwabedissen, H M, Nauck, M, Nederhof, E, Petschner, P, Peyrot, W J, Schwahn, C, Sinnamon, G, Stacey, D, Tian, Y, Toben, C, Van der Auwera, S, Wainwright, N, Wang, J-C, Willemsen, G, Anderson, I M, Arolt, V, Åslund, C, Bagdy, G, Baune, B T, Bellivier, F, Boomsma, D I, Courtet, P, Dannlowski, U, de Geus, E J C, Deakin, J F W, Easteal, S, Eley, T, Fergusson, D M, Goate, A M, Gonda, X, Grabe, H J, Holzman, C, Johnson, E O, Kennedy, M, Laucht, M, Martin, N G, Munafò, M R, Nilsson, K W, Oldehinkel, A J, Olsson, C A, Ormel, J, Otte, C, Patton, G C, Penninx, B W J H, Ritchie, K, Sarchiapone, M, Scheid, J M, Serretti, A, Smit, J H, Stefanis, N C, Surtees, P G, Völzke, H, Weinstein, M, Whooley, M, Nurnberger, J I, Breslau, N & Bierut, L J 2017, ' Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression ', Molecular Psychiatry, vol. 23, pp. 133–142 . https://doi.org/10.1038/mp.2017.44
Molecular Psychiatry, 23, 133-142. Nature Publishing Group
Molecular Psychiatry, 23(1), 133-142. Nature Publishing Group
Culverhouse, R C, Saccone, N L, Horton, A C, Anstey, K J, Banaschewski, T, Burmeister, M, Cohen-Woods, S, Etain, B, Fisher, H L, Goldman, N, Guillaume, S, Horwood, J, Juhasz, G, Lester, K J, Mandelli, L, Middeldorp, C M, Olié, E, Villafuerte, S, Air, T M, Araya, R, Bowes, L, Byrne, E M, Coffey, C, Coventry, W L, Gawronski, K A B, Glei, D, Hatzimanolis, A, Hottenga, J-J, Jaussent, I, Jawahar, C, Jennen-Steinmetz, C, Kramer, J R, Lajnef, M, Zu Schwabedissen, H M, Nauck, M, Nederhof, E, Petschner, P, Peyrot, W J, Schwahn, C, Sinnamon, G, Tian, Y, Toben, C, Van der Auwera, S, Wainwright, N, Willemsen, G, Anderson, I M, Arolt, V, Åslund, C, Bagdy, G, Baune, B T, Bellivier, F, Boomsma, D I, Courtet, P, Dannlowski, U, de Geus, E J C, Deakin, J F W, Easteal, S, Eley, T, Fergusson, D M, Goate, A M, Gonda, X, Grabe, H J, Holzman, C, Laucht, M, Munafò, M R, Nilsson, K W, Oldehinkel, A J, Olsson, C A, Ormel, J, Otte, C, Patton, G C, Penninx, B W J H, Ritchie, K, Sarchiapone, M, Scheid, J M, Serretti, A, Stefanis, N C, Surtees, P G, Völzke, H, Weinstein, M, Whooley, M, Nurnberger, J I, Breslau, N & Bierut, L J 2018, ' Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression ', Molecular Psychiatry, vol. 23, no. 1, pp. 133-142 . https://doi.org/10.1038/mp.2017.44
Molecular Psychiatry
Molecular Psychiatry, Nature Publishing Group, 2018, 23 (1), pp.133--142. ⟨10.1038/mp.2017.44⟩
Culverhouse, R C, Saccone, N L, Horton, A C, Ma, Y, Anstey, K J, Banaschewski, T, Burmeister, M, Cohen-Woods, S, Etain, B, Fisher, H L, Goldman, N, Guillaume, S, Horwood, J, Juhasz, G, Lester, K J, Mandelli, L, Middeldorp, C M, Olié, E, Villafuerte, S, Air, T M, Araya, R, Bowes, L, Burns, R, Byrne, E M, Coffey, C, Coventry, W L, Gawronski, K A B, Glei, D, Hatzimanolis, A, Hottenga, J J, Jaussent, I, Jawahar, C, Jennen-Steinmetz, C, Kramer, J R, Lajnef, M, Little, K, Zu Schwabedissen, H M, Nauck, M, Nederhof, E, Petschner, P, Peyrot, W J, Schwahn, C, Sinnamon, G, Stacey, D, Tian, Y, Toben, C, Van Der Auwera, S, Wainwright, N, Wang, J C, Willemsen, G, Anderson, I M, Arolt, V, Aslund, C, Bagdy, G, Baune, B T, Bellivier, F, Boomsma, D I, Courtet, P, Dannlowski, U, De Geus, E J C, Deakin, J F W, Easteal, S, Eley, T, Fergusson, D M, Goate, A M, Gonda, X, Grabe, H J, Holzman, C, Johnson, E O, Kennedy, M, Laucht, M, Martin, N G, Munafò, M R, Nilsson, K W, Oldehinkel, A J, Olsson, C A, Ormel, J, Otte, C, Patton, G C, Penninx, B W J H, Ritchie, K, Sarchiapone, M, Scheid, J M, Serretti, A, Smit, J H, Stefanis, N C, Surtees, P G, Völzke, H, Weinstein, M, Whooley, M, Nurnberger, J I, Breslau, N & Bierut, L J 2018, ' Collaborative meta-Analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression ', Molecular Psychiatry, vol. 23, no. 1, pp. 133-142 . https://doi.org/10.1038/mp.2017.44
Molecular psychiatry

The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is associated with increased risk of depression, but only in individuals exposed to stressful situations, has generated much interest, research and controversy sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6e272421cf2db41f79fb4339d34947
https://hdl.handle.net/1871.1/a867d0ad-f3ba-415d-8864-2e5179ee0216