Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Katerina, Vlasakova"'
Autor:
Katerina Vlasakova, Takayuki Tsuchiya, Ivy N. Garfinkel, Michael P. Ruth, Cheryl Tyszkiewicz, Theodore J. Detwiler, Christopher J. Somps, Lorenzo Di Cesare Mannelli, Warren E. Glaab
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
BackgroundTarget organ toxicity is often a reason for attritions in nonclinical and clinical drug development. Leveraging emerging safety biomarkers in nonclinical studies provides an opportunity to monitor such toxicities early and efficiently, pote
Externí odkaz:
https://doaj.org/article/4d8d7f29be7c447e94c5af3685054aa9
Autor:
Katerina, Vlasakova, Jennifer, Bourque, Wendy J, Bailey, Shetal, Patel, Elizabeth G, Besteman, Raymond J, Gonzalez, Frank D, Sistare, Warren E, Glaab
Publikováno v:
Toxicological Sciences. 187:219-233
The ability to monitor for general drug-induced tissue injury (DITI) or systemic inflammation in any tissue using blood-based accessible biomarkers would provide a valuable tool in early exploratory animal studies to understand potential drug liabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b063b32a14b4046a9ff7c68d7d3fd6a5
https://doi.org/10.1093/toxsci/kfac030
https://doi.org/10.1093/toxsci/kfac030
Autor:
Stephanie Born, Yi-Zhong Gu, Larry Handt, Vasudevan Bakthavatchalu, Katerina Vlasakova, Frank D. Sistare, Guillermo Fernandez, Warren E. Glaab, Roger Smith
Publikováno v:
Toxicologic Pathology. 50:35-46
Kidney biopsies are used sparingly to diagnose kidney injury in the clinic. Here we have conducted a small exploratory study to directly compare the low-grade kidney injury monitoring performance of serum safety biomarkers, novel urine safety biomark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7000c83ea307a501b9d6a6443782431f
https://doi.org/10.1177/01926233211049171
https://doi.org/10.1177/01926233211049171
Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats
Autor:
Yi-Zhong Gu, Katerina Vlasakova, Glen Miller, Nicholas T. Gatto, Paul J. Ciaccio, Sabu Kuruvilla, Elizabeth G. Besteman, Roger Smith, Spencer J. Reynolds, Rupesh P. Amin, Warren E. Glaab, Gordon Wollenberg, Jose Lebron, Frank D. Sistare
Publikováno v:
Toxicologic Pathology. :019262332311628
Activating mutations of the leucine-rich repeat kinase 2 ( LRRK2) gene are associated with Parkinson disease (PD), prompting development of LRRK2 inhibitors as potential treatment for PD. However, kidney safety concerns have surfaced from LRRK2 knock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca81b65118f034c663e621457909c3ff
https://doi.org/10.1177/01926233231162809
https://doi.org/10.1177/01926233231162809
Autor:
Bhavana Bhatt, Frank D. Sistare, Kiran Palyada, Feifei Chen, Isabelle Bourgeois, Christopher Brynczka, Rupesh P. Amin, Katerina Vlasakova, José A. Lebrón, Roger Smith, Kenneth A. Koeplinger, Kenneth D Anderson, Kathleen Cox, Robert Houle, Warren E. Glaab, Yi-Zhong Gu, Xiaoyan Chu
Publikováno v:
Toxicological Sciences. 172:155-166
MK-7680, a cyclic nucleotide prodrug, caused significant kidney tubule injury in female rats when administered orally at 1000 mg/kg/day for 2 weeks using 10% Polysorbate 80 as vehicle. However, kidney injury was absent when MK-7680 was administered a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7c8a93f2d09b4d982560ba5c94462b
https://doi.org/10.1093/toxsci/kfz186
https://doi.org/10.1093/toxsci/kfz186
Publikováno v:
Seminars in Nephrology. 39:202-214
Acute kidney injury continues to be a common problem and there continues to be a medical need for sensitive translational biomarkers for clinical monitoring. The past decade has yielded unprecedented progress in fundamental research into novel kidney
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963639c19be732c6ce807d060d2193e7
https://doi.org/10.1016/j.semnephrol.2018.12.008
https://doi.org/10.1016/j.semnephrol.2018.12.008
Publikováno v:
Toxicologic pathology. 48(5)
To date, there has been very little published data evaluating the performance of novel urinary kidney biomarkers in nonhuman primates (NHPs). To assess the biomarker performance and characterize the corresponding histomorphologic patterns of tubular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010759ec4ac355eb7dcf4292328ba910
https://pubmed.ncbi.nlm.nih.gov/32633702
https://pubmed.ncbi.nlm.nih.gov/32633702
Autor:
Erjia Wang, Frank D. Sistare, Katerina Vlasakova, Jude Ferraro, Yi-Zhong Gu, Jarig Darbes, Warren E. Glaab
Publikováno v:
Toxicology. 439
Drug-induced kidney injury (DIKI) is a frequent occurrence in nonclinical drug development. It is well established that novel urine kidney safety biomarkers will outperform urea nitrogen (BUN) and serum creatinine (sCr) for monitoring direct drug inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82e91f2012dc73002a1d60b92e74360
https://pubmed.ncbi.nlm.nih.gov/32348786
https://pubmed.ncbi.nlm.nih.gov/32348786
Publikováno v:
Lipids. 53:947-960
Proteins involved in lipid homeostasis are often regulated through the nuclear peroxisome proliferator-activated receptors (PPAR). PPARα is the target for the fibrate-class of drugs. Fenofibrate has been approved for its lipid-lowering effects in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8469fd347f3bc59c8f6365ce5355f20a
https://doi.org/10.1002/lipd.12110
https://doi.org/10.1002/lipd.12110
Autor:
Sean P. Troth, Robert L. Peiffer, Herve Tournade, Frank D. Sistare, Warren E. Glaab, Yi-Zhong Gu, Flavia R Pasello Dos Santos, Katerina Vlasakova
Publikováno v:
Toxicologic Pathology. 46:553-563
Newer urinary protein kidney safety biomarkers can outperform the conventional kidney functional biomarkers blood urea nitrogen (BUN) and serum creatinine (SCr) in rats. However, there is far less experience with the relative performance of these bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd44801ab77fa3f251af52ab25a76f25
https://doi.org/10.1177/0192623318775023
https://doi.org/10.1177/0192623318775023