Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kateri A. Ahrendt"'
Autor:
Augustine N. Vu, Santana P. Garcia, Jenny H. Tran, Adrian A. Godoy, Joaquin M. Mesa, Cassidy M. DiTirro, Kinsey L. Kotsch, Sarah E. Sullivan, Vincent J. Tavalez, Kateri A. Ahrendt
Publikováno v:
Journal of Chemical Education. 100:914-920
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e0fd16ce3bbdc505a1be2d30de66682
https://doi.org/10.1021/acs.jchemed.2c01097
https://doi.org/10.1021/acs.jchemed.2c01097
Publikováno v:
Biochemistry. 53:202-213
Class II fructose 1,6-bisphosphate aldolase (FBA) is an enzyme critical for bacterial, fungal, and protozoan glycolysis/gluconeogenesis. Importantly, humans lack this type of aldolase, having instead a class I FBA that is structurally and mechanistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fccaeab224bc9005218f97d59f10f3
https://doi.org/10.1021/bi401022b
https://doi.org/10.1021/bi401022b
Autor:
Alexandre J. Buckmelter, Kateri A. Ahrendt, Susan L. Gloor, Ellen R. Laird, Steve Wenglowsky, Nathalie Klopfenstein, Bainian Feng, Xianfeng Li, Jonas Grina, Li Ren, Brad Newhouse, Zhaoyang Wen, Walter C. Voegtli, Joachim Rudolph
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5896-5899
This Letter details the synthesis and evaluation of imidazo[4,5-b]pyridines as inhibitors of B-Raf kinase. These compounds bind in a DFG-in, αC-helix out conformation of B-Raf, which is a binding mode associated with significant kinase selectivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ac7a3d9b7f5f24125f9fe3a150e5ef
https://doi.org/10.1016/j.bmcl.2013.08.086
https://doi.org/10.1016/j.bmcl.2013.08.086
Autor:
Ben Colson, David A. Moreno, Alisha Arrigo, Yingqing Ran, Kateri A. Ahrendt, Joachim Rudolph, Gregg Hastings, Susan L. Gloor, Steve Wenglowsky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:912-915
A single crystal was obtained of a lead B-RafV600E inhibitor with low aqueous solubility. The X-ray crystal structure revealed hydrogen-bonded head-to-tail dimers formed by the pyrazolopyridine and sulfonamide groups of a pair of molecules. This obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82986908f732d32d815b58b28f062936
https://doi.org/10.1016/j.bmcl.2011.12.030
https://doi.org/10.1016/j.bmcl.2011.12.030
Publikováno v:
The Journal of Organic Chemistry. 70:6775-6781
A directed C-H bond activation approach to the synthesis of indans, tetralins, dihydrofurans, dihydroindoles, and other polycyclic aromatic compounds is presented. Cyclization of aromatic ketimines and aldimines containing alkenyl groups tethered at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e25a36af7aaa46aa067aed7ed479ea
https://doi.org/10.1021/jo050757e
https://doi.org/10.1021/jo050757e
Publikováno v:
Organic Letters. 5:1301-1303
[reaction: see text] A tetrahydrobis(benzofuran) mescaline analogue has been prepared in six steps and 38% overall yield from (4'-O-methyl)methyl gallate. The key step in this synthesis is a tandem cyclization reaction via directed C[bond]H activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411b95cd426e2b57756038b0cca20416
https://doi.org/10.1021/ol034228d
https://doi.org/10.1021/ol034228d
Autor:
Jonas Grina, David A. Moreno, Alexandre J. Buckmelter, Ellen R. Laird, Steve Wenglowsky, Li Ren, Jeongbeob Seo, Bainian Feng, Simon Mathieu, Stefan Gradl, Joachim Rudolph, Susan L. Gloor, Paul Lunghofer, Brad Newhouse, Walter C. Voegtli, Kateri A. Ahrendt, Joshua D. Hansen, Tyler Risom, Zhaoyang Wen, Hillary L. Sturgis
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
Structure–activity relationships around a novel series of B-RafV600E inhibitors are reported. The enzymatic and cellular potencies of inhibitors derived from two related hinge-binding groups were compared and3-methoxypyrazolopyridine proved to be s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86d6896cc1f135b8465ad0a1a4349c6
https://pubmed.ncbi.nlm.nih.gov/21802293
https://pubmed.ncbi.nlm.nih.gov/21802293
Autor:
Kim Malesky, Victoria Dinkel, Bruno Alicke, Hillary L. Sturgis, Simon Mathieu, Ignacio Aliagas, Sumeet Rana, Kyung Song, Brandon S. Willis, Bonnie Liu, Nikole Randolph, Yingqing Ran, Scott Savage, Wendy B. Young, Edna F. Choo, Ellen R. Laird, Steve Wenglowsky, Stephen E. Gould, Bainian Feng, Michael Shrag, Joachim Rudolph, Li Ren, Kateri A. Ahrendt, Nicholas J. Raddatz, Walter C. Voegtli, Tyler Risom, LeAnn T. Selby, Jonas Grina, Zhaoyang Wen, Susan L. Gloor, Janet Gunzner-Toste, Wen-I Wu, Alexandre J. Buckmelter, Brad Newhouse, Richard Woessner, Stefan Gross, Joshua D. Hansen, Georgia Hatzivassiliou
Publikováno v:
ACS medicinal chemistry letters. 2(5)
The V600E mutation of B-Raf kinase results in constitutive activation of the MAPK signaling pathway and is present in approximately 7% of all cancers. Using structure-based design, a novel series of pyrazolopyridine inhibitors of B-Raf(V600E) was dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7453447f90b377bcf825db60a43c00ae
https://pubmed.ncbi.nlm.nih.gov/24900315
https://pubmed.ncbi.nlm.nih.gov/24900315
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a436ccfab3a83cb47a688b9ad3b54b4f
https://doi.org/10.1002/chin.200031035
https://doi.org/10.1002/chin.200031035
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3fadba5807022fd2d92d9e5caf6b12d
https://doi.org/10.1002/chin.200205033
https://doi.org/10.1002/chin.200205033