Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Katelynn R Kazane"'
Autor:
Lauren K Quezada, Wenhao Jin, Yi Chia Liu, Eleanor S Kim, Zhaoren He, Cynthia S Indralingam, Tiffani Tysl, Lara Labarta-Bajo, Ellen J Wehrens, Yeara Jo, Katelynn R Kazane, Christopher Hattori, Elina I Zuniga, Gene W Yeo, John T Chang
Publikováno v:
PLoS Biology, Vol 21, Iss 1, p e3001983 (2023)
During a microbial infection, responding CD8+ T cells give rise to effector cells that provide acute host defense and memory cells that provide sustained protection. An alternative outcome is exhaustion, a state of T cell dysfunction that occurs in t
Externí odkaz:
https://doaj.org/article/7b4ece8f50d847b580332c8f6b7493f7
Autor:
Beeke Wienert, David N. Nguyen, Alexis Guenther, Sharon J. Feng, Melissa N. Locke, Stacia K. Wyman, Jiyung Shin, Katelynn R. Kazane, Georgia L. Gregory, Matthew A. M. Carter, Francis Wright, Bruce R. Conklin, Alex Marson, Chris D. Richardson, Jacob E. Corn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Altering cellular responses to double-strand breaks in DNA could rebalance CRISPRediting outcomes. Here, the authors use a pooled CRISPR screen to identify inhibition of CDC7 as a strategy to improve HDR outcomes.
Externí odkaz:
https://doaj.org/article/6ea294e461964f21b3fa07be064041d4
Publikováno v:
Trends Immunol
Trends in immunology, vol 43, iss 7
Trends in immunology, vol 43, iss 7
Emerging immunotherapies offer a new hope for cancer patients but are not always effective even when a tumor is recognized by the immune system. Baldominos and colleagues address this challenge by characterizing a resilient niche of metabolically uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702d24cf9ff9e0c7a3de4699f0d84241
https://europepmc.org/articles/PMC9674368/
https://europepmc.org/articles/PMC9674368/
Autor:
Alexis Guenther, Francis Wright, Katelynn R. Kazane, Sharon J. Feng, Matthew Carter, Jiyung Shin, Jacob E. Corn, David N. Nguyen, Alexander Marson, Melissa N. Locke, Beeke Wienert, Bruce R. Conklin, Stacia K. Wyman, Christopher D. Richardson, Georgia L. Gregory
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, 11 (1)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications, 11 (1)
Nature Communications
Nature communications, vol 11, iss 1
Repair of double strand DNA breaks (DSBs) can result in gene disruption or gene modification via homology directed repair (HDR) from donor DNA. Altering cellular responses to DSBs may rebalance editing outcomes towards HDR and away from other repair
Autor:
Elina I. Zuniga, Anna Gramalla-Schmitz, Karenina Sanders, Katelynn R. Kazane, Tara Schwartz, Gregory Humphrey, Lara Labarta-Bajo, Manuela Raffatellu, Romana R. Gerner, Rob Knight, Austin D. Swafford
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 40
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 40
Infections elicit immune adaptations to enable pathogen resistance and/or tolerance and are associated with compositional shifts of the intestinal microbiome. However, a comprehensive understanding of how infections with pathogens that exhibit distin
Autor:
Stacia K. Wyman, Johannes C. Walter, Leo C. Chen, Jonathan T. Vu, Jiyung J. Shin, Katelynn R. Kazane, R. Alex Wu, Benjamin G. Gowen, Christopher D. Richardson, Jacob E. Corn, Alan S. Wang
Publikováno v:
Molecular cell, vol 79, iss 2
SummaryCas9 is a prokaryotic RNA-guided DNA endonuclease that binds substrates tightly in vitro but turns over rapidly when used to manipulate genomes in eukaryotic cells. Little is known about the factors responsible for dislodging Cas9 or how they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df03a53b46269259f32a76c35ec6542
https://doi.org/10.1101/705657
https://doi.org/10.1101/705657
Autor:
Parker Sevier, Olivia Brobst, Sai Alam, Ivonne G. Romero, Zilla Kailani, Keeyon Dabrian, Nam Phuong Do, Rina Watanabe, Ryan Ngo, Wenyuan Wei, Alisa Sukhina, Samuel Wu, Min-Ying Wu, Stephanie B. Orchanian, Lauren Brenner, Samantha F. Mosier, Hannah Kim, Carly Pierson, Justin E. Miller, Nikolina Walas, Siobhan McCarthy, Marcia Brinck, Rohan Luhar, Mikael Sanchez, Emma C. Goodwin, Hayley A. Ennis, Xinyu Ma, Christina T. Fournier, Andrew J. Lund, Paola Nol-Bernardino, Drake W. Williams, Joyce Wang, Oyinlola Sawyerr, Joel Laskow, Joseph M. Gaballa, Aika Miikeda, William Villella, Darwin Wu, Amitoj Singh, Alysha N. Salbato, Erin Sakaji, Christy J. Kim, Michael A. Murphy, Annie Chen, Jordan Moberg Parker, Rachel Desai, Yousif Kettoola, Boon Xin Tan, Rebecca Fernando, Yiwei Sun, Alexandra Sarkis, Amanda C. Freise, Diane Park, Katelynn R. Kazane
Publikováno v:
Microbiology resource announcements, vol 8, iss 2
Microbiology Resource Announcements
Microbiology Resource Announcements
Mycobacteriophages Deby, LaterM, LilPharaoh, Paola, SgtBeansprout, and Sulley were isolated from soil using Mycobacterium smegmatis mc2155. Genomic analysis indicated that they belong to subclusters K1 and K5.
Mycobacteriophages Deby, LaterM, Li
Mycobacteriophages Deby, LaterM, Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c6e01cc5f94e9e643023f6280f53ee
https://escholarship.org/uc/item/2f71d7x6
https://escholarship.org/uc/item/2f71d7x6
Autor:
Sharon J. Feng, Stacia K. Wyman, Katelynn R. Kazane, Alexander Marson, Melissa N. Locke, Christopher D. Richardson, Jacob E. Corn, David N. Nguyen, Beeke Wienert
Repair of double strand DNA breaks (DSBs) can result in gene disruption or precise gene modification via homology directed repair (HDR) from a templating donor DNA. During genome editing, altering cellular responses to DSBs may be an effective strate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a8569ed561bddca06cc44dcf01e54f
https://doi.org/10.1101/500462
https://doi.org/10.1101/500462
Autor:
Yvonne Hao, Leo C. Chen, Alan S. Wang, David T. McSwiggen, Christopher D. Richardson, Alec Heckert, R. Alex Wu, Jacob E. Corn, Johannes C. Walter, Jonathan T. Vu, Stacia K. Wyman, Benjamin G. Gowen, Jiyung J. Shin, Katelynn R. Kazane, Xavier Darzacq
Publikováno v:
Mol Cell
Summary Cas9 is a prokaryotic RNA-guided DNA endonuclease that binds substrates tightly in vitro but turns over rapidly when used to manipulate genomes in eukaryotic cells. Little is known about the factors responsible for dislodging Cas9 or how they
Autor:
Nicholas L. Bray, Katelynn R. Kazane, Stephen N. Floor, Jacob E. Corn, Christopher D. Richardson, Sharon J. Feng, Axel J. Schäfer, Elena Zelin
Publikováno v:
Nature genetics. 50(8)
CRISPR–Cas genome editing creates targeted DNA double-strand breaks (DSBs) that are processed by cellular repair pathways, including the incorporation of exogenous DNA via single-strand template repair (SSTR). To determine the genetic basis of SSTR