Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Katelyn. J. Kozma"'
Autor:
Nathan F. Schachter, Jessica R. Adams, Patryk Skowron, Katelyn. J. Kozma, Christian A. Lee, Nandini Raghuram, Joanna Yang, Amanda J. Loch, Wei Wang, Aaron Kucharczuk, Katherine L. Wright, Rita M. Quintana, Yeji An, Daniel Dotzko, Jennifer L. Gorman, Daria Wojtal, Juhi S. Shah, Paul Leon-Gomez, Giovanna Pellecchia, Adam J. Dupuy, Charles M. Perou, Ittai Ben-Porath, Rotem Karni, Eldad Zacksenhaus, Jim R. Woodgett, Susan J. Done, Livia Garzia, A. Sorana Morrissy, Jüri Reimand, Michael D. Taylor, Sean E. Egan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Transposon based screens carried out in mice can identify genes critical for tumourigensis. Here, the authors describe transposon screens in mouse models of breast cancer and highlight a large group of tumour suppressors that could underlie selection
Externí odkaz:
https://doaj.org/article/7b80ad2dd67744ecb57557946c051bff
Autor:
Nandini Raghuram, E. Idil Temel, Toshihiro Kawamata, Katelyn J. Kozma, Amanda J. Loch, Wei Wang, Jessica R. Adams, William J. Muller, Sean E. Egan
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-12 (2024)
Abstract Copy number gains in genes coding for Rho activating exchange factors as well as losses affecting genes coding for RhoGAP proteins are common in breast cancer (BC), suggesting that elevated Rho signaling may play an important role. Extra cop
Externí odkaz:
https://doaj.org/article/9bb3dfba366749538f9812dc3140b0b5
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Systematically investigating the scores of genes mutated in cancer and discerning disease drivers from inconsequential bystanders is a prerequisite for precision medicine but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3e88720028d1c1acd19d4e081944a9
https://doi.org/10.1158/2159-8290.c.6549708.v1
https://doi.org/10.1158/2159-8290.c.6549708.v1
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Supplementary Data from Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0b4da81cbb00416f796f44e9fdd2b9
https://doi.org/10.1158/2159-8290.22541622.v1
https://doi.org/10.1158/2159-8290.22541622.v1
Autor:
Yeji An, Jessica R. Adams, Daniel P. Hollern, Anthony Zhao, Stephen G. Chang, Miki S. Gams, Philip E.D. Chung, Xiaping He, Rhea Jangra, Juhi S. Shah, Joanna Yang, Lauren A. Beck, Nandini Raghuram, Katelyn J. Kozma, Amanda J. Loch, Wei Wang, Cheng Fan, Susan J. Done, Eldad Zacksenhaus, Cynthia J. Guidos, Charles M. Perou, Sean E. Egan
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 702-714.e6 (2018)
Summary: CDH1 and PIK3CA are the two most frequently mutated genes in invasive lobular carcinoma (ILC) of the breast. Transcription profiling has identified molecular subtypes for ILC, one of which, immune-related (IR), is associated with gene expres
Externí odkaz:
https://doaj.org/article/e6fd22c930404eb59b9f40602f0d2a1c
Autor:
Ahmed El-Boraie, Stefanie Mak, David C.F. Sealey, Katelyn. J. Kozma, Jonathan Chio, Anne Meyer-Miner
Publikováno v:
Canadian Journal of Career Development. 20:84-93
In the life sciences, many graduate students and postdoctoral fellows find it challenging to enter the non-academic workforce after completing their programs. Through experiential learning, trainees can develop the knowledge, technical skills, soft s
Autor:
Zhibo Ma, Ricky Tsai, Miquel Angel Pujana, Geoffrey M. Wahl, Seda Barutcu, Sampath Kumar Loganathan, Katelyn. J. Kozma, Roderic Espín, Rod Bremner, Dan Trcka, Ellen Langille, Daniel Schramek, Ahmad Malik, Thomas Nguyen, Jeff C. Liu, Sean E. Egan, Katie Teng, Erik S. Knudsen, Gary D. Bader, Jeff Wrana, Hartland W. Jackson, Khalid N Al-Zahrani
Systematically investigating the scores of genes mutated in cancer and discerning real drivers from inconsequential bystanders is a prerequisite for Precision Medicine, but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ac8b66e265f67391d390be78544478
https://doi.org/10.1101/2021.10.22.465428
https://doi.org/10.1101/2021.10.22.465428
Autor:
Christian A. Lee, Adam J. Dupuy, Eldad Zacksenhaus, Daniel Dotzko, Susan J. Done, Nandini Raghuram, Nathan F. Schachter, Sean E. Egan, Amanda J. Loch, Rita M. Quintana, A. Sorana Morrissy, Giovanna Pellecchia, Ittai Ben-Porath, Charles M. Perou, Joanna Yang, Juhi S. Shah, Jennifer L. Gorman, Michael D. Taylor, Patryk Skowron, Jüri Reimand, Daria Wojtal, Jessica R. Adams, James R. Woodgett, Paul Leon-Gomez, Aaron Kucharczuk, Yeji An, Wei Wang, Katelyn. J. Kozma, Katherine L. Wright, Livia Garzia, Rotem Karni
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The most common events in breast cancer (BC) involve chromosome arm losses and gains. Here we describe identification of 1089 gene-centric common insertion sites (gCIS) from transposon-based screens in 8 mouse models of BC. Some gCIS are driver-speci
Autor:
Ellen Langille, Khalid N. Al-Zahrani, Zhibo Ma, Minggao Liang, Liis Uuskula-Reimand, Roderic Espin, Katie Teng, Ahmad Malik, Helga Bergholtz, Samah El Ghamrasni, Somaieh Afiuni-Zadeh, Ricky Tsai, Sana Alvi, Andrew Elia, YiQing Lü, Robin H. Oh, Katelyn J. Kozma, Daniel Trcka, Masahiro Narimatsu, Jeff C. Liu, Thomas Nguyen, Seda Barutcu, Sampath K. Loganathan, Rod Bremner, Gary D. Bader, Sean E. Egan, David W. Cescon, Therese Sørlie, Jeffrey L. Wrana, Hartland W. Jackson, Michael D. Wilson, Agnieszka K. Witkiewicz, Erik S. Knudsen, Miguel Angel Pujana, Geoffrey M. Wahl, Daniel Schramek
Publikováno v:
Cancer Discov
Systematically investigating the scores of genes mutated in cancer and discerning disease drivers from inconsequential bystanders is a prerequisite for precision medicine but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis s
Autor:
Rhea Jangra, Daniel P. Hollern, Xiaping He, Sean E. Egan, Susan J. Done, Miki S. Gams, Lauren A. Beck, Nandini Raghuram, Amanda J. Loch, Cheng Fan, Juhi S. Shah, Eldad Zacksenhaus, Cynthia J. Guidos, Anthony Zhao, Joanna Yang, Stephen Chang, Philip E.D. Chung, Wei Wang, Katelyn. J. Kozma, Yeji An, Jessica R. Adams, Charles M. Perou
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 702-714.e6 (2018)
Cell reports
Cell reports
SUMMARY CDH1 and PIK3CA are the two most frequently mutated genes in invasive lobular carcinoma (ILC) of the breast. Transcription profiling has identified molecular subtypes for ILC, one of which, immune-related (IR), is associated with gene express