Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Katelyn R. Titus"'
Autor:
Yemin Lan, Gerd A. Blobel, Peng Huang, Ross C. Hardison, Hongxin Wang, Katelyn R. Titus, Thomas G. Gilgenast, Haoyue Zhang, Jennifer E. Phillips-Cremins, Di Zhang, Daniel J. Emerson, Belinda Giardine, Cheryl A. Keller
Publikováno v:
Nature
Features of higher-order chromatin organization-such as A/B compartments, topologically associating domains and chromatin loops-are temporarily disrupted during mitosis1,2. Because these structures are thought to influence gene regulation, it is impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d5717342c8e55996cca821760ec0d0
https://doi.org/10.1038/s41586-019-1778-y
https://doi.org/10.1038/s41586-019-1778-y
Autor:
Thomas G. Gilgenast, Margaret C. Dunagin, Jonathan A. Beagan, Arjun Raj, Ji Hun Kim, Wanfeng Gong, Aryeh Metzger, Katelyn R. Titus, Jennifer E. Phillips-Cremins, Mayuri Rege, Jacqueline Valeri
Publikováno v:
Nature Methods. 16:633-639
Mammalian genomes are folded into tens of thousands of long-range looping interactions. The cause-and-effect relationship between looping and genome function is poorly understood, and the extent to which loops are dynamic on short time scales remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb3a3c32132ef9e5563ba60a6bfd835
https://doi.org/10.1038/s41592-019-0436-5
https://doi.org/10.1038/s41592-019-0436-5
Autor:
Wallace O, Linda Zhou, Jesi Kim, Su C, Hao Wu, Chandradoss Kr, Rojas A, Malachowski T, Wanfeng Gong, Ge C, Katelyn R. Titus, Jennifer E. Phillips-Cremins
Short tandem repeat (STR) instability is causally linked to pathologic transcriptional silencing in a subset of repeat expansion disorders. In fragile X syndrome (FXS), instability of a single CGG STR tract is thought to repress FMR1 via local DNA me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::210153627d7fb807fe7b78c4ae178fea
https://doi.org/10.1101/2021.04.23.441217
https://doi.org/10.1101/2021.04.23.441217
Autor:
Daniel J. Emerson, Peiyao A. Zhao, Ashley L. Cook, R. Jordan Barnett, Kyle N. Klein, Dalila Saulebekova, Chunmin Ge, Linda Zhou, Zoltan Simandi, Miriam K. Minsk, Katelyn R. Titus, Weitao Wang, Wanfeng Gong, Di Zhang, Liyan Yang, Sergey V. Venev, Johan H. Gibcus, Hongbo Yang, Takayo Sasaki, Masato T. Kanemaki, Feng Yue, Job Dekker, Chun-Long Chen, David M. Gilbert, Jennifer E. Phillips-Cremins
Publikováno v:
Nature. 606(7915)
DNA replication occurs through an intricately regulated series of molecular events and is fundamental for genome stability1,2. At present, it is unknown how the locations of replication origins are determined in the human genome. Here we dissect the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd24f7ab9499fb37e47d80273457909
https://pubmed.ncbi.nlm.nih.gov/35676475
https://pubmed.ncbi.nlm.nih.gov/35676475
Autor:
Katelyn R. Titus, Danielle S. Bassett, Jesi Kim, Shi Gu, Jennifer E. Phillips-Cremins, Daniel J. Emerson, Heidi K. Norton, Harvey Huang
Publikováno v:
Nature Methods. 15:119-122
Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs), subTADs and looping interactions. Here, we describe 3DNetMod, a graph theory-based method for sensitive and accurate detection of chromatin domains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76469803c62a2e8529077abee92e181
https://doi.org/10.1038/nmeth.4560
https://doi.org/10.1038/nmeth.4560
Autor:
Harvey Huang, Sunnia T. Chen, Daniel J. Emerson, Katelyn R. Titus, Danielle S. Bassett, Jennifer E. Phillips-Cremins
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Mammalian genomes are folded into a hierarchy of compartments, topologically associating domains (TADs), subTADs, and long-range looping interactions. The higher-order folding patterns of chromatin contacts within TADs and how they localize to diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350f5a2bd11850961163b7b3ea76da29
https://doi.org/10.1038/s41598-019-45457-9
https://doi.org/10.1038/s41598-019-45457-9
Autor:
Ross C. Hardison, Belinda Giardine, Gerd A. Blobel, David Zhang, Katelyn R. Titus, Hongxin Wang, Yemin Lan, Cheryl A. Keller, Peng Huang, Thomas G. Gilgenast, Haoyue Zhang, Daniel J. Emerson, Jennifer E. Phillips-Cremins
Higher-order chromatin organization such as A/B compartments, TADs and chromatin loops are temporarily disrupted during mitosis. These structures are thought to organize aspects of gene regulation, and thus it is important to understand how they are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b92d0c29bf656a1526a02f21a5984e4
https://doi.org/10.1101/604355
https://doi.org/10.1101/604355
Autor:
Harshini Chandrashekar, Kelly Feng, Elissa D. Pastuzyn, Jason D. Shepherd, Katelyn R. Titus, Michael H. Guo, Lindsey R. Fernandez, Jonathan A. Beagan, Jennifer E. Phillips-Cremins
Publikováno v:
Nature Neuroscience. 23:1309-1309
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a0c9eb3950b679f55037f8e056d6bd4
https://doi.org/10.1038/s41593-020-0683-x
https://doi.org/10.1038/s41593-020-0683-x
Autor:
Sai Aung Phyo, Jonathan A. Beagan, Jennifer E. Phillips-Cremins, Katelyn R. Titus, Daniel J. Emerson, James H. Sun, Flora Tassone, Linda Zhou, Wanfeng Gong, Thomas G. Gilgenast, Beverly L. Davidson
Publikováno v:
Cell, vol 175, iss 1
More than 25 inherited human disorders are causedby the unstable expansion of repetitive DNA sequences termed short tandem repeats (STRs). Afundamental unresolved question is why some STRs are susceptible to pathologic expansion, whereas thousands of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164c299d1c4d8cc5716d6231dd2b5220
https://pubmed.ncbi.nlm.nih.gov/30241613
https://pubmed.ncbi.nlm.nih.gov/30241613
Autor:
Ji Hun Kim, Jonathan A. Beagan, Wanfeng Gong, Zhendong Cao, Katelyn R. Titus, Jennifer E. Phillips-Cremins
Publikováno v:
Methods (San Diego, Calif.). 142
Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs), subTADs and looping interactions. Currently, there is a great need to evaluate the link between chromatin topology and genome function across many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266bf6631168ea620b2d302d9929d3ca
https://pubmed.ncbi.nlm.nih.gov/29772275
https://pubmed.ncbi.nlm.nih.gov/29772275