Výsledky vyhledávání - "Katelyn Pickerell"

Akademický článek

Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway

Autor: Lakshmi Reddy Palam, Baskar Ramdas, Katelyn Pickerell, Santhosh Kumar Pasupuleti, Rahul Kanumuri, Annamaria Cesarano, Megan Szymanski, Bryce Selman, Utpal P. Dave, George Sandusky, Fabiana Perna, Sophie Paczesny, Reuben Kapur

Publikováno v: JCI Insight, Vol 8, Iss 9 (2023)

Loss-of-function mutations in the DNA methyltransferase 3A (DNMT3A) are seen in a large number of patients with acute myeloid leukemia (AML) with normal cytogenetics and are frequently associated with poor prognosis. DNMT3A mutations are an early pre

Externí odkaz: https://doaj.org/article/ec0e132ad5ae448a979e9b996e562b3e

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PI3K Signaling Is Essential for Leukemic Transformation of Tet2 Mutated Pre-Leukemic Hematopoietic Stem Cells

Autor: Lakshmi Reddy Palam, Baskar Ramdas, Katelyn Pickerell, Maegan L. Capitano, Reuben Kapur

Publikováno v: Blood. 140:5736-5736

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9427cdc5adeb29800173b9b17e4fc85b
https://doi.org/10.1182/blood-2022-166430

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Loss of Dnmt3a Dysregulates Hematopoietic Homeostasis and Myeloid Skewing Via the PI3Kinase Pathway: PI3Kα/β Inhibition Corrects Extramedullary Hematopoiesis and Myeloid Skewing Due to Loss of Dnmt3a

Autor: Reuben Kapur, Lakshmi Reddy Palam, Baskar Ramdas, Katelyn Pickerell

Publikováno v: Blood. 134:723-723

Mutations in DNA methyltransferase type 3A (DNMT3A) are frequently associated with myeloid malignancies including myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and myeloproliferative neoplasms (MPN) including systemic mastocytosis (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f99c51230ece14e5f268cea25bd2c022
https://doi.org/10.1182/blood-2019-131036

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