Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Katelyn L Donahue"'
Autor:
Rosa E Menjivar, Zeribe C Nwosu, Wenting Du, Katelyn L Donahue, Hanna S Hong, Carlos Espinoza, Kristee Brown, Ashley Velez-Delgado, Wei Yan, Fatima Lima, Allison Bischoff, Padma Kadiyala, Daniel Salas-Escabillas, Howard C Crawford, Filip Bednar, Eileen Carpenter, Yaqing Zhang, Christopher J Halbrook, Costas A Lyssiotis, Marina Pasca di Magliano
Publikováno v:
eLife, Vol 12 (2023)
An extensive fibroinflammatory stroma rich in macrophages is a hallmark of pancreatic cancer. In this disease, it is well appreciated that macrophages are immunosuppressive and contribute to the poor response to immunotherapy; however, the mechanisms
Externí odkaz:
https://doaj.org/article/2b78244f89f74a1a8452e4521a5af646
Autor:
Ashley M. Mello, Tenzin Ngodup, Yusoo Lee, Katelyn L. Donahue, Jinju Li, Arvind Rao, Eileen S. Carpenter, Howard C. Crawford, Marina Pasca di Magliano, Kyoung Eun Lee
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-9 (2022)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibroinflammatory stroma and often experiences conditions of insufficient oxygen availability or hypoxia. Cancer-associated fibroblasts (CAF) are a predominant and hete
Externí odkaz:
https://doaj.org/article/58ecf0cb5fb64401ae4dd519669818f1
Autor:
Ashley Velez-Delgado, Katelyn L. Donahue, Kristee L. Brown, Wenting Du, Valerie Irizarry-Negron, Rosa E. Menjivar, Emily L. Lasse Opsahl, Nina G. Steele, Stephanie The, Jenny Lazarus, Veerin R. Sirihorachai, Wei Yan, Samantha B. Kemp, Samuel A. Kerk, Murali Bollampally, Sion Yang, Michael K. Scales, Faith R. Avritt, Fatima Lima, Costas A. Lyssiotis, Arvind Rao, Howard C. Crawford, Filip Bednar, Timothy L. Frankel, Benjamin L. Allen, Yaqing Zhang, Marina Pasca di Magliano
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 6, Pp 1673-1699 (2022)
Background & Aims: Oncogenic Kirsten Rat Sarcoma virus (KRAS) is the hallmark mutation of human pancreatic cancer and a driver of tumorigenesis in genetically engineered mouse models of the disease. Although the tumor cell–intrinsic effects of onco
Externí odkaz:
https://doaj.org/article/20125fcc27cc45cf89b627da102ba12b
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract DNA damage activates cell cycle checkpoint proteins ATR and CHK1 to arrest cell cycle progression, providing time for repair and recovery. Consequently, inhibitors of ATR (ATRi) and CHK1 (CHK1i) enhance damage-induced cell death. Intriguingl
Externí odkaz:
https://doaj.org/article/5351eae2b961433688e264c109fd09cc
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 4 (2022)
A challenge in cancer treatment is targeting cancer cells while sparing normal cells. Thus, identifying cancer-specific neoepitopes is an active research area. Neoepitopes are generated by the accumulation of mutations; however, deadly cancer types,
Externí odkaz:
https://doaj.org/article/f640bbf642394ddf97712c828bce657c
Autor:
Eileen S. Carpenter, Ahmed M. Elhossiny, Padma Kadiyala, Jay Li, Jake McGue, Brian D. Griffith, Yaqing Zhang, Jacob Edwards, Sarah Nelson, Fatima Lima, Katelyn L. Donahue, Wenting Du, Allison C. Bischoff, Danyah Alomari, Hannah R. Watkoske, Michael Mattea, Stephanie The, Carlos E. Espinoza, Meredith Barrett, Christopher J. Sonnenday, Nicholas Olden, Chin-Tung Chen, Nicole Peterson, Valerie Gunchick, Vaibhav Sahai, Arvind Rao, Filip Bednar, Jiaqi Shi, Timothy L. Frankel, Marina Pasca di Magliano
Publikováno v:
Cancer Discovery. :OF1-OF22
The adult healthy human pancreas has been poorly studied given the lack of indication to obtain tissue from the pancreas in the absence of disease and rapid postmortem degradation. We obtained pancreata from brain dead donors, thus avoiding any warm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d98b3201f5411a8f889186166354d09b
https://doi.org/10.1158/2159-8290.cd-23-0013
https://doi.org/10.1158/2159-8290.cd-23-0013
Autor:
Marina Pasca di Magliano, Timothy L. Frankel, Jiaqi Shi, Filip Bednar, Arvind Rao, Vaibhav Sahai, Valerie Gunchick, Nicole Peterson, Chin-Tung Chen, Nicholas Olden, Christopher J. Sonnenday, Meredith Barrett, Carlos E. Espinoza, Stephanie The, Michael Mattea, Hannah R. Watkoske, Danyah Alomari, Allison C. Bischoff, Wenting Du, Katelyn L. Donahue, Fatima Lima, Sarah Nelson, Jacob Edwards, Yaqing Zhang, Brian D. Griffith, Jake McGue, Jay Li, Padma Kadiyala, Ahmed M. Elhossiny, Eileen S. Carpenter
Supplementary Figures 11-14 and associated legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e2851b1aac04e7630e63d78fb6ca62
https://doi.org/10.1158/2159-8290.22893203.v1
https://doi.org/10.1158/2159-8290.22893203.v1
Autor:
Marina Pasca di Magliano, Timothy L. Frankel, Jiaqi Shi, Filip Bednar, Arvind Rao, Vaibhav Sahai, Valerie Gunchick, Nicole Peterson, Chin-Tung Chen, Nicholas Olden, Christopher J. Sonnenday, Meredith Barrett, Carlos E. Espinoza, Stephanie The, Michael Mattea, Hannah R. Watkoske, Danyah Alomari, Allison C. Bischoff, Wenting Du, Katelyn L. Donahue, Fatima Lima, Sarah Nelson, Jacob Edwards, Yaqing Zhang, Brian D. Griffith, Jake McGue, Jay Li, Padma Kadiyala, Ahmed M. Elhossiny, Eileen S. Carpenter
Supplementary Figures 1-10 and associated legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147f92c726a77efd899b947c6faadc6a
https://doi.org/10.1158/2159-8290.22893206.v1
https://doi.org/10.1158/2159-8290.22893206.v1
Autor:
Marina Pasca di Magliano, Timothy L. Frankel, Jiaqi Shi, Filip Bednar, Arvind Rao, Vaibhav Sahai, Valerie Gunchick, Nicole Peterson, Chin-Tung Chen, Nicholas Olden, Christopher J. Sonnenday, Meredith Barrett, Carlos E. Espinoza, Stephanie The, Michael Mattea, Hannah R. Watkoske, Danyah Alomari, Allison C. Bischoff, Wenting Du, Katelyn L. Donahue, Fatima Lima, Sarah Nelson, Jacob Edwards, Yaqing Zhang, Brian D. Griffith, Jake McGue, Jay Li, Padma Kadiyala, Ahmed M. Elhossiny, Eileen S. Carpenter
The adult healthy human pancreas has been poorly studied given the lack of indication to obtain tissue from the pancreas in the absence of disease and rapid postmortem degradation. We obtained pancreata from brain dead donors, thus avoiding any warm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260ee69ee57860896d40af7361746e9f
https://doi.org/10.1158/2159-8290.c.6651113.v1
https://doi.org/10.1158/2159-8290.c.6651113.v1
Autor:
Marina Pasca di Magliano, Timothy L. Frankel, Jiaqi Shi, Filip Bednar, Arvind Rao, Vaibhav Sahai, Valerie Gunchick, Nicole Peterson, Chin-Tung Chen, Nicholas Olden, Christopher J. Sonnenday, Meredith Barrett, Carlos E. Espinoza, Stephanie The, Michael Mattea, Hannah R. Watkoske, Danyah Alomari, Allison C. Bischoff, Wenting Du, Katelyn L. Donahue, Fatima Lima, Sarah Nelson, Jacob Edwards, Yaqing Zhang, Brian D. Griffith, Jake McGue, Jay Li, Padma Kadiyala, Ahmed M. Elhossiny, Eileen S. Carpenter
Supplemental Table 1: Demographics and clinical data for donor Gife of Life Samples Supplemental Table 2: Putative Ligand-Receptor pairs comparing all cell types from single cell sequencing of tumor samples compared to healthy samples. Supplemental T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a78f049197275aec8cd25798761439
https://doi.org/10.1158/2159-8290.22893200.v1
https://doi.org/10.1158/2159-8290.22893200.v1