Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons

Autor: Kalpana Makhijani, Brandy Alexander, Deepti Rao, Sophia Petraki, Leire Herboso, Katelyn Kukar, Itrat Batool, Stephanie Wachner, Katrina S. Gold, Corinna Wong, Michael B. O’Connor, Katja Brückner

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Hematopoietic sites in theDrosophilalarva require the local peripheral nervous system for blood cells (hemocytes) to survive and proliferate, but how this is mediated is unclear. Here, the authors identify Activin-β from sensory neurons as signallin

Externí odkaz: https://doaj.org/article/9187e1f8cb4f4d59831554b315e0c04e

Multi-Trait Genetic Analysis Identifies Autoimmune Loci Associated with Cutaneous Melanoma

Autor: Upekha E. Liyanage, Stuart MacGregor, D. Timothy Bishop, Jianxin Shi, Jiyuan An, Jue Sheng Ong, Xikun Han, Richard A. Scolyer, Nicholas G. Martin, Sarah E. Medland, Enda M. Byrne, Adèle C. Green, Robyn P.M. Saw, John F. Thompson, Jonathan Stretch, Andrew Spillane, Yunxuan Jiang, Chao Tian, Scott G. Gordon, David L. Duffy, Catherine M. Olsen, David C. Whiteman, Georgina V. Long, Mark M. Iles, Maria Teresa Landi, Matthew H. Law, Michelle Agee, Stella Aslibekyan, Adam Auton, Elizabeth Babalola, Robert K. Bell, Jessica Bielenberg, Katarzyna Bryc, Emily Bullis, Briana Cameron, Daniella Coker, Gabriel Cuellar Partida, Devika Dhamija, Sayantan Das, Sarah L. Elson, Teresa Filshtein, Kipper Fletez-Brant, Pierre Fontanillas, Will Freyman, Pooja M. Gandhi, Karl Heilbron, Barry Hicks, David A. Hinds, Karen E. Huber, Ethan M. Jewett, Aaron Kleinman, Katelyn Kukar, Keng-Han Lin, Maya Lowe, Marie K. Luff, Jennifer C. McCreight, Matthew H. McIntyre, Kimberly F. McManus, Steven J. Micheletti, Meghan E. Moreno, Joanna L. Mountain, Sahar V. Mozaffari, Priyanka Nandakumar, Elizabeth S. Noblin, Jared O'Connell, Aaron A. Petrakovitz, G. David Poznik, Anjali J. Shastri, Janie F. Shelton, Jingchunzi Shi, Suyash Shringarpure, Vinh Tran, Joyce Y. Tung, Xin Wang, Wei Wang, Catherine H. Weldon, Peter Wilton

Publikováno v: The Journal of investigative dermatology. 142(6)

Genome-wide association studies (GWAS) have identified a number of risk loci for cutaneous melanoma. Cutaneous melanoma shares overlapping genetic risk (genetic correlation) with a number of other traits, including its risk factors such as sunburn pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581d67a66b4cc294aa0af7b7ad820155
https://pubmed.ncbi.nlm.nih.gov/34813871

Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons

Autor: Katelyn Kukar, Itrat Batool, Deepti Rao, Katja Brückner, Stephanie Wachner, Leire Herboso, Sophia Petraki, Michael B. O'Connor, Kalpana Makhijani, Brandy Alexander, Katrina S. Gold, Corinna Wong

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications, vol 8, iss 1
Nature Communications

An outstanding question in animal development, tissue homeostasis and disease is how cell populations adapt to sensory inputs. During Drosophila larval development, hematopoietic sites are in direct contact with sensory neuron clusters of the periphe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1272729046ab80e94aeba4cd997607ac
https://doaj.org/article/9187e1f8cb4f4d59831554b315e0c04e

Blood Cells of Adult Drosophila Do Not Expand, But Control Survival after Bacterial Infection by Induction of Drosocin Around Their Reservoir at the Respiratory Epithelia

Autor: Katja Brückner, Pablo Sanchez Bosch, Katelyn Kukar, David Ouyang, Frederic Geissmann, Rowan Baginsky, Katrina S. Gold, Brandy Alexander, Leire Herboso, Sean P. Corcoran, Katie J. Woodcock, Kalpana Makhijani, Elodie Ramond, Bruno Lemaitre, Eduardo Moreno, Candance Wong, Christa Rhiner

Publikováno v: SSRN Electronic Journal.

Drosophila melanogaster has been an excellent model for innate immunity, but the role and regulation of adult blood cells and organismal immunity have remained incompletely understood. Here we address these questions in a comprehensive investigation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49f1902fae66901c7b59194efeffac11
https://doi.org/10.2139/ssrn.3363774