Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Katelyn E. Swindle-Reilly"'
Publikováno v:
Frontiers in Medicine, Vol 8 (2022)
PurposeAge-related eye diseases are becoming more prevalent. A notable increase has been seen in the most common causes including glaucoma, age-related macular degeneration (AMD), and cataract. Current clinical treatments vary from tissue replacement
Externí odkaz:
https://doaj.org/article/1b4c3c6f4881466b9bce98ab46d2a54f
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 6 (2018)
The vitreous humor is a fragile, transparent hydrogel situated between the lens and the retina, occupying 80% of the eye's volume. Due to its viscoelastic behavior, the vitreous serves as a mechanical damper for the eye, absorbing impacts, and protec
Externí odkaz:
https://doaj.org/article/f3c6ffacf5924e498325400ce16c300e
Publikováno v:
bioRxiv
Macula clears our central vision and sharpens our visibility. The macula is positioned in the middle of the retinal tissue. Age-related macular degeneration (AMD) is a condition brought on by macular deterioration. In the United States, millions of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab004aa24bb9f0da81007a81ef0751d
https://europepmc.org/articles/PMC10197542/
https://europepmc.org/articles/PMC10197542/
Autor:
Megan M. Allyn, Maria A. Rincon-Benavides, Heather L. Chandler, Natalia Higuita-Castro, Andre F. Palmer, Katelyn E. Swindle-Reilly
Publikováno v:
Biomaterials Science. 10:7004-7014
Globally, age-related macular degeneration (AMD) is the third most common visual impairment. Most often attributed to cellular fatigue with aging, over expression of reactive oxygen species (ROS) causes ROS accumulation in the retina, leading to chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89ed1edeaa036376d904427f30d2ec8
https://doi.org/10.1039/d2bm00905f
https://doi.org/10.1039/d2bm00905f
Publikováno v:
Molecular Pharmaceutics. 17:2570-2584
The current therapy for treating neovascular age-related macular degeneration requires monthly intravitreal injection of angiogenesis inhibitors such as bevacizumab or ranibizumab via a 31-gauge needle to inhibit choroidal neovascularization. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c74001c0f31c1829f693872a4c1117
https://doi.org/10.1021/acs.molpharmaceut.0c00260
https://doi.org/10.1021/acs.molpharmaceut.0c00260
Autor:
Clayton T. Cuddington, Katelyn E Swindle-Reilly, Pengfei Jiang, Francisco J. Chaparro, Matthew Ohr, Andre F. Palmer, John J. Lannutti
Publikováno v:
Journal of Controlled Release. 320:442-456
Vascular endothelial growth factor (VEGF) is a key regulator of abnormal blood vessel growth. As such, bevacizumab-based inhibition of VEGF has been the clinically adopted strategy to treat colorectal and breast cancers as well as age-related macular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7c605e309788d2f39af7d6fbf9da115
https://doi.org/10.1016/j.jconrel.2020.01.036
https://doi.org/10.1016/j.jconrel.2020.01.036
Autor:
Courtney J. Maxwell, Andrew M. Soltisz, Wade W. Rich, Andrew Choi, Matthew A. Reilly, Katelyn E. Swindle‐Reilly
Publikováno v:
Journal of biomedical materials research. Part A. 110(10)
Many disease pathologies, particularly in the eye, are induced by oxidative stress. In particular, injury to the optic nerve (ON), or optic neuropathy, is one of the most common causes of vision loss. Traumatic optic neuropathy (TON) occurs when the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b9ed6db3c5aef6b08e6957ed9178ad
https://pubmed.ncbi.nlm.nih.gov/35607724
https://pubmed.ncbi.nlm.nih.gov/35607724
Publikováno v:
Current eye research. 46(4)
Tissues in the eye are particularly susceptible to oxidative damage due to light exposure. While vitamin C (ascorbic acid) has been noted as a vital antioxidant in the vitreous humor, its physiological concentration (1-2 mM) has been shown to be toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d401d0cccfa96a9859edbed74fa923ff
https://pubmed.ncbi.nlm.nih.gov/32838548
https://pubmed.ncbi.nlm.nih.gov/32838548
Publikováno v:
Nanoscale. 12(33)
Reactive oxidative species (ROS) are the primary mediator of angiogenesis by upregulating the expression of vascular endothelial growth factor (VEGF) in the development of wet age-related macular degeneration (AMD). However, the current treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8a10cf474d7ce226e887e3c178f345
https://pubmed.ncbi.nlm.nih.gov/32789323
https://pubmed.ncbi.nlm.nih.gov/32789323
Research on the vitreous humor and development of hydrogel vitreous substitutes have gained a rapid increase in interest within the past two decades. However, the properties of the vitreous humor and vitreous substitutes have yet to be consolidated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccac5772c5f0ec52c3806148dd282947