Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Katelyn Connell"'
Autor:
Yoshiji Hantani, Kiyosei Iio, Rie Hantani, Kayo Umetani, Toshihiro Sato, Tracy Young, Katelyn Connell, Sam Kintz, Joshua Salafsky
Publikováno v:
FEBS Open Bio, Vol 8, Iss 9, Pp 1412-1423 (2018)
Many clinically approved protein kinase inhibitors stabilize an inactive conformation of their kinase target. Such inhibitors are generally highly selective compared to active conformation inhibitors, and consequently, general methods to identify inh
Externí odkaz:
https://doaj.org/article/8d0437040b1b4dbdb797c18f711baa16
Autor:
Tracy A. Young, Toshihiro Sato, Sam Kintz, Kayo Umetani, Kiyosei Iio, Rie Hantani, Joshua Salafsky, Yoshiji Hantani, Katelyn Connell
Publikováno v:
FEBS Open Bio
Many clinically approved protein kinase inhibitors stabilize an inactive conformation of their kinase target. Such inhibitors are generally highly selective compared to active conformation inhibitors, and consequently, general methods to identify inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7635a31bde6e39756a249e1ddbc85cf7
https://doi.org/10.1002/2211-5463.12489
https://doi.org/10.1002/2211-5463.12489
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 41
The molten globule, a conformational ensemble with significant secondary structure but only loosely packed tertiary structure, has been suggested to be a ubiquitous intermediate in protein folding. However, it is difficult to assess the tertiary pack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b90fb004be5f9ae4e1f14b5d0bf8dd9
https://europepmc.org/articles/PMC4205613/
https://europepmc.org/articles/PMC4205613/
Autor:
Osman Bilsel, Susan Marqusee, Laura E. Rosen, C. Robert Matthews, Katelyn Connell, Sagar V. Kathuria
Publikováno v:
Biophysical Journal. 106(2)
E. coli ribonuclease H has been an important model system for protein folding for many years. It has long been known that it folds through an intermediate (Icore) en route to the native state. However, because folding to Icore occurs on the fast mill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a45ce2a65bbb503a961d97d58fa25f6
Understanding the nature of partially folded intermediates transiently populated during protein folding is important for understanding both protein folding and misfolding. These ephemeral species, however, often elude direct experimental characteriza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486ddcf0846ff9b14ab54fee1a10f79b
https://europepmc.org/articles/PMC2881687/
https://europepmc.org/articles/PMC2881687/
Autor:
Jason W Hoskins, Charles C Chung, Aidan O'Brien, Jun Zhong, Katelyn Connelly, Irene Collins, Jianxin Shi, Laufey T Amundadottir
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11, p e1009563 (2021)
Expression QTL (eQTL) analyses have suggested many genes mediating genome-wide association study (GWAS) signals but most GWAS signals still lack compelling explanatory genes. We have leveraged an adipose-specific gene regulatory network to infer expr
Externí odkaz:
https://doaj.org/article/3cfa69e4504e4ee18a45f811c36157b1
Publikováno v:
Biophysical Journal. (3):448a
Proteins can sample a variety of partially folded conformations during the transition between the unfolded and native states. Some proteins never significantly populate these high-energy states and fold by an apparently two-state process. What factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1980f4e10135d8a85c5737bc29859d2b