Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Katelyn Cassidy"'
Autor:
Jonathan D. Taylor, Nathalie Barrett, Sergio Martinez Cuesta, Katelyn Cassidy, Fiona Pachl, James Dodgson, Radhika Patel, Tuula M. Eriksson, Aidan Riley, Matthew Burrell, Christin Bauer, D. Gareth Rees, Raffaello Cimbro, Andrew X. Zhang, Ralph R. Minter, James Hunt, Sandrine Legg
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Proteins can be targeted for degradation by engineering biomolecules that direct them to the eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a ‘biological
Externí odkaz:
https://doaj.org/article/82c3864e38134c29b42485f93454e6e6
Autor:
Heng Zhao, Katelyn Cassidy
Publikováno v:
Biochemistry. 62:580-587
The advent of multi-specific targeted protein degradation (TPD) therapies has made it possible to drug targets that have long been considered to be inaccessible. For this reason, the foremost TPD modalities - molecular glues and proteolysis targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecde442d28922cc10b6b40136d911bec
https://doi.org/10.1021/acs.biochem.1c00330
https://doi.org/10.1021/acs.biochem.1c00330
Publikováno v:
SLAS Discovery. 26:518-523
Mass spectrometry-based proteomics profiling is a discovery tool that enables researchers to understand the mechanisms of action of drug candidates. When applied to proteolysis targeting chimeras (PROTACs) such approaches provide unbiased perspective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5251b9012618b03cdc776a059f0ee1
https://doi.org/10.1177/2472555220985776
https://doi.org/10.1177/2472555220985776