Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Katelyn Becker"'
Autor:
Thomas M. Goralski, Lindsay Meyerdirk, Libby Breton, Laura Brasseur, Kevin Kurgat, Daniella DeWeerd, Lisa Turner, Katelyn Becker, Marie Adams, Daniel J. Newhouse, Michael X. Henderson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract A key hallmark of Parkinson’s disease (PD) is Lewy pathology. Composed of α-synuclein, Lewy pathology is found both in dopaminergic neurons that modulate motor function, and cortical regions that control cognitive function. Recent work ha
Externí odkaz:
https://doaj.org/article/adda231edd6d4dd9bf1d27ea3cc41c46
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Cognitive dysfunction is a salient feature of Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB). The onset of dementia reflects the spread of Lewy pathology throughout forebrain structures. The mere presence of Lewy pathology, h
Externí odkaz:
https://doaj.org/article/1ee0873a032f4228bf5674a0cb96385f
Autor:
Hongqiao Zhang, Carla D'Agostino, Christopher Tulisiak, Max A. Thorwald, Liza Bergkvist, Allison Lindquist, Lindsay Meyerdirk, Emily Schulz, Katelyn Becker, Jennifer A. Steiner, Mafalda Cacciottolo, Mohit Kwatra, Nolwen L. Rey, Martha L. Escobar Galvis, Jiyan Ma, Constantinos Sioutas, Todd E. Morgan, Caleb E. Finch, Patrik Brundin
Publikováno v:
Heliyon, Vol 9, Iss 4, Pp e15622- (2023)
Background: Epidemiological studies have variably linked air pollution to increased risk of Parkinson’s disease (PD). However, there is little experimental evidence for this association. Alpha-synuclein (α-syn) propagation plays central roles in P
Externí odkaz:
https://doaj.org/article/2cb7b45f11bf473183868a0bdea5ceb7
Autor:
Xinhe Wang, Katelyn Becker, Nathan Levine, Michelle Zhang, Andrew P. Lieberman, Darren J. Moore, Jiyan Ma
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-14 (2019)
Abstract Misfolded alpha-synuclein (αSyn) is a major constituent of Lewy bodies and Lewy neurites, which are pathological hallmarks of Parkinson’s disease (PD). The contribution of αSyn to PD is well established, but the detailed mechanism remain
Externí odkaz:
https://doaj.org/article/fb0bbddddb9e4da18dd59b561c49ab95
Autor:
Wouter Peelaerts, Liza Bergkvist, Sonia George, Michaela Johnson, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Zachary Madaj, Jiyan Ma, Katelyn Becker, K. Peter R. Nilsson, Jerry R. Colca, Patrik Brundin
Publikováno v:
Free Neuropathology, Vol 1, Pp 33-33 (2020)
Epidemiological studies suggest a link between type-2 diabetes and Parkinson’s disease (PD) risk. Treatment of type-2 diabetes with insulin sensitizing drugs lowers the risk of PD. We previously showed that the insulin sensitizing drug, MSDC-0160,
Externí odkaz:
https://doaj.org/article/1a77645d12c548a3ba5d9c06a4db6d52
Autor:
Stewart F. Graham, Nolwen L. Rey, Zafer Ugur, Ali Yilmaz, Eric Sherman, Michael Maddens, Ray O. Bahado-Singh, Katelyn Becker, Emily Schulz, Lindsay K. Meyerdirk, Jennifer A. Steiner, Jiyan Ma, Patrik Brundin
Publikováno v:
Metabolites, Vol 8, Iss 4, p 71 (2018)
For people with Parkinson’s disease (PD), considered the most common neurodegenerative disease behind Alzheimer’s disease, accurate diagnosis is dependent on many factors; however, misdiagnosis is extremely common in the prodromal phases of the d
Externí odkaz:
https://doaj.org/article/0003ce4bbc2641999a3bd8d919795571
Autor:
Sonia George, Wouter Peelaerts, Amanda R. Burmeister, J. Andrew Pospisilik, Katelyn Becker, Emily Schulz, Jennifer A. Steiner, Rachael Sheridan, Lena Brundin, Viviane Labrie, Trevor A. Tyson, Nolwen L. Rey, Patrik Brundin, Jiyan Ma, Christian Ulrich von Linstow, Lindsay Meyerdirk, Martha L. Escobar Galvis
Publikováno v:
J Parkinsons Dis
BACKGROUND: α-Synuclein (α-syn) is the predominant protein in Lewy-body inclusions, which are pathological hallmarks of α-synucleinopathies, such as Parkinson's disease (PD) and multiple system atrophy (MSA). Other hallmarks include activation of
Publikováno v:
Journal of Parkinson's Disease
Background: Synucleinopathy is a group of neurodegenerative disorders characterized by neurodegeneration and accumulation of alpha-synuclein (α-syn) aggregates in various brain regions. The detailed mechanism of α-syn-caused neurotoxicity remains o
Autor:
Katelyn Becker, Darren J. Moore, Andrew P. Lieberman, Xinhe Wang, Jiyan Ma, Michelle Zhang, Nathan Levine
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-14 (2019)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Misfolded alpha-synuclein (αSyn) is a major constituent of Lewy bodies and Lewy neurites, which are pathological hallmarks of Parkinson’s disease (PD). The contribution of αSyn to PD is well established, but the detailed mechanism remains obscure
Autor:
Jiyan Ma, Jennifer A. Steiner, Yazhou Li, Zachary Madaj, Michaela E. Johnson, Gabriela Mercado, Lindsay Meyerdirk, Katelyn Becker, Emily Schulz, Liza Bergkvist, Patrik Brundin
Publikováno v:
Experimental neurology. 341
The repurposing of drugs developed to treat type 2 diabetes for the treatment of Parkinson's disease (PD) was encouraged by the beneficial effect exerted by the glucagon-like peptide 1 (GLP-1) analogue exenatide in a phase 2 clinical trial. The effec