Výsledky vyhledávání - "Katelin M. Allan"

Akademický článek

Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a Q1291H/F508del patient

Autor: Katelin M. Allan, Miro A. Astore, Egi Kardia, Sharon L. Wong, Laura K. Fawcett, Jessica L. Bell, Simone Visser, Po-Chia Chen, Renate Griffith, Adam Jaffe, Sheila Sivam, Orazio Vittorio, Serdar Kuyucak, Shafagh A. Waters

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Background: Cystic fibrosis (CF) is caused by a wide spectrum of mutations in the CF transmembrane conductance regulator (CFTR) gene, with some leading to non-classical clinical presentations. We present an integrated in vivo, in silico and in vitro

Externí odkaz: https://doaj.org/article/983bc3fd05834594ba1500ce3059b03f

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Akademický článek

S945L-CFTR molecular dynamics, functional characterization and tezacaftor/ivacaftor efficacy in vivo and in vitro in matched pediatric patient-derived cell models

Autor: Katelin M. Allan, Miro A. Astore, Laura K. Fawcett, Sharon L. Wong, Po-Chia Chen, Renate Griffith, Adam Jaffe, Serdar Kuyucak, Shafagh A. Waters

Publikováno v: Frontiers in Pediatrics, Vol 10 (2022)

Cystic Fibrosis (CF) results from over 400 different disease-causing mutations in the CF Transmembrane Conductance Regulator (CFTR) gene. These CFTR mutations lead to numerous defects in CFTR protein function. A novel class of targeted therapies (CFT

Externí odkaz: https://doaj.org/article/09f769a9358d4b8cb345d160205f200c

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Akademický článek

Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity

Autor: Sharon L. Wong, Nikhil T. Awatade, Miro A. Astore, Katelin M. Allan, Michael J. Carnell, Iveta Slapetova, Po-chia Chen, Alexander Capraro, Laura K. Fawcett, Renee M. Whan, Renate Griffith, Chee Y. Ooi, Serdar Kuyucak, Adam Jaffe, Shafagh A. Waters

Publikováno v: iScience, Vol 25, Iss 1, Pp 103710- (2022)

Summary: Characterization of I37R, a mutation located in the lasso motif of the CFTR chloride channel, was conducted by theratyping several CFTR modulators from both potentiator and corrector classes. Intestinal current measurements in rectal biopsie

Externí odkaz: https://doaj.org/article/9a4dc92c469442f8afda25d75b18cedf

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Akademický článek

Treatment of Cystic Fibrosis: From Gene- to Cell-Based Therapies

Autor: Katelin M. Allan, Nigel Farrow, Martin Donnelley, Adam Jaffe, Shafagh A. Waters

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Prognosis of patients with cystic fibrosis (CF) varies extensively despite recent advances in targeted therapies that improve CF transmembrane conductance regulator (CFTR) function. Despite being a multi-organ disease, extensive lung tissue destructi

Externí odkaz: https://doaj.org/article/1e14f6b35c784199b62a7ff5d60c6ef1

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Comparing Cytology Brushes for Optimal Human Nasal Epithelial Cell Collection: Implications for Airway Disease Diagnosis and Research

Autor: Laura K. Fawcett, Nihan Turgutoglu, Katelin M. Allan, Yvonne Belessis, John Widger, Adam Jaffe, Shafagh A. Waters

Publikováno v: Journal of Personalized Medicine. 13:864

Primary nasal epithelial cells and culture models are used as important diagnostic, research and drug development tools for several airway diseases. Various instruments have been used for the collection of human nasal epithelial (HNE) cells but no gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdcc6807df20471d6abbcecf5eb59c42
https://doi.org/10.3390/jpm13050864

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Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect

Autor: Sharon L. Wong, Nikhil T. Awatade, Miro A. Astore, Katelin M. Allan, Michael J. Carnell, Iveta Slapetova, Po-chia Chen, Jeffry Setiadi, Elvis Pandzic, Laura K. Fawcett, John R. Widger, Renee M. Whan, Renate Griffith, Chee Y. Ooi, Serdar Kuyucak, Adam Jaffe, Shafagh A. Waters

Publikováno v: American journal of respiratory cell and molecular biology. 67(1)

A significant challenge to making targeted cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies accessible to all individuals with cystic fibrosis (CF) are many mutations in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d89092fb399986af7e85a474198fd08
https://pubmed.ncbi.nlm.nih.gov/35471184

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Collection, Expansion, and Differentiation of Primary Human Nasal Epithelial Cell Models for Quantification of Cilia Beat Frequency

Autor: Elvis Pandzic, Alexander Capraro, Shafagh A. Waters, Sharon L. Wong, Cristan Herbert, Laura K. Fawcett, Katelin M. Allan, Adam Jaffe

Publikováno v: Journal of visualized experiments : JoVE. (177)

Measurements of cilia function (beat frequency, pattern) have been established as diagnostic tools for respiratory diseases such as primary ciliary dyskinesia. However, the wider application of these techniques is limited by the extreme susceptibilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68a2bf9e34ea22fd42a914a021e6490
https://pubmed.ncbi.nlm.nih.gov/34842237

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Quantifying Intracellular Viral Pathogen: Specimen Preparation, Visualization and Quantification of Multiple Immunofluorescent Signals in Fixed Human Airway Epithelium Cultured at Air-Liquid Interface

Autor: Sharon L. Wong, Elvis Pandzic, Egi Kardia, Katelin M. Allan, Renee M. Whan, Shafagh A. Waters

Publikováno v: Journal of Personalized Medicine. 12:1668

Infection control and aggressive antibiotic therapy play an important role in the management of airway infections in individuals with cystic fibrosis (CF). The responses of airway epithelial cells to pathogens are likely to contribute to the pathobio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79344db744cf319996b0340bd15c6f51
https://doi.org/10.3390/jpm12101668

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Molecular dynamics and theratyping in airway and gut organoids reveal R352Q-CFTR conductance defect

Autor: Katelin M. Allan, Jeffry Setiadi, Serdar Kuyucak, Laura K. Fawcett, John R. Widger, Renee Whan, Sharon L. Wong, Po-chia Chen, Michael Carnell, Adam Jaffe, Iveta Slapetova, Chee Y. Ooi, Shafagh A. Waters, Elvis Pandzic, Renate Griffith, Nikhil T. Awatade, Miro A. Astore

A significant challenge to making targeted CFTR modulator therapies accessible to all individuals with cystic fibrosis (CF) are many mutations in the CFTR gene that can cause CF, most of which remain uncharacterized. Here, we characterized the struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ae71c9509600baaccdbd97ba3ff84db
https://doi.org/10.1101/2021.08.11.456003

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