Is personal physiology-based rapid prediction digital twin for minimal effective fentanyl dose better than standard practice: a pilot study protocol

Autor: Simon Annaheim, Katelijne De Nys, Markus Jörger, Milena Cukic, Flora Bahrami, Thijs Defraeye

Publikováno v: BMJ Open, Vol 14, Iss 9 (2024)

Introduction Patients with advanced cancer frequently suffer from chronic, severe disabling pain. Opioids such as morphine and fentanyl are commonly used to manage this pain. Transdermal drug delivery systems are important technologies for administer

Externí odkaz: https://doaj.org/article/5200264ef674429b991789163f193d9c

An individualized digital twin of a patient for transdermal fentanyl therapy for chronic pain management

Autor: Flora Bahrami, Rene Michel Rossi, Katelijne De Nys, Thijs Defraeye

Publikováno v: Bahrami, Flora; Rossi, René Michel; De Nys, Katelijne; Defraeye, Thijs (2023). An individualized digital twin of a patient for transdermal fentanyl therapy for chronic pain management. (In Press). Drug delivery and translational research Springer 10.1007/s13346-023-01305-y

Fentanyl transdermal therapy is a suitable treatment for moderate-to-severe cancer-related pain. Patients show inter-individual drug uptake behavior, which leads to a different response to the therapy. This study aims to determine the effect of diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ee6ad215632eba131d85de7294a427
https://doi.org/10.1007/s13346-023-01305-y

Predictors for reimbursement of oncology drugs in Belgium between 2002 and 2013

Autor: Kim Pauwels, Steven Simoens, Katelijne De Nys, Minne Casteels, Isabelle Huys

Publikováno v: Expert Review of Pharmacoeconomics & Outcomes Research. 15:859-868

Background: Price setting and reimbursement decisions regarding drugs are competence of individual member states in Europe. These decisions involve important trade-offs between social, ethical, clinical and economic criteria. The aim of this study wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f27f6c51383da89dac1a6e5c2f4ce29
https://doi.org/10.1586/14737167.2015.1047347

It is time to revise the international Good Clinical Practices guidelines: recommendations from non-commercial North–South collaborative trials

Autor: Alain Nahum, Ermias Diro, Joseph Okebe, Katelijne De Nys, Yodi Mahendradhata, Suman Rijal, Halidou Tinto, Raffaella Ravinetto, Minne Casteels, Pascal Lutumba, Eduardo Gotuzzo, Marleen Boelaert

Publikováno v: BMJ Global Health

The Good Clinical Practices (GCP) codes of the WHO and the International Conference of Harmonization set international standards for clinical research. But critics argue that they were written without consideration for the challenges faced in low and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b70417381be71af579b92b95cff74d
http://europepmc.org/articles/PMC5321366

Sponsorship in non-commercial clinical trials: definitions, challenges and the role of Good Clinical Practices guidelines

Autor: Minne Casteels, Ermias Diro, Raffaella Ravinetto, Marleen Boelaert, Katelijne De Nys, Yeka Adoke, Harry Tagbor, Graeme Meintjes

Publikováno v: BMC International Health and Human Rights

Background Non-commercial clinical research plays an increasingly essential role for global health. Multiple partners join in international consortia that operate under the limited timeframe of a specific funding period. One organisation (the sponsor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2686d0547f76bd550bb6cc7dd93c574
https://pubmed.ncbi.nlm.nih.gov/26715307