Výsledky vyhledávání - "Katelijne Anciaux"

Strategies for Absorption Screening in Drug Discovery and Development

Autor: Hilde Bohets, K. Lavrijsen, Katelijne Anciaux, Pieter Annaert, Peter Verboven, Geert Mannens, Willem Meuldermans, Ludy van Beijsterveldt

Publikováno v: Current Topics in Medicinal Chemistry. 1:367-383

This review gives an overview of the current approaches to evaluate drug absorption potential in the different phases of drug discovery and development. Methods discussed include in silico models, artificial membranes as absorption models, in vitro m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81adf5af46a759b4b7f7e150f868ec21
https://doi.org/10.2174/1568026013394886

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An Ecto-Nucleotide Pyrophosphatase Is One of the Main Enzymes Involved in the Extracellular Metabolism of ATP in Rat C6 Glioma

Autor: Herman Slegers, Bert Grobben, Eddy L. Esmans, Katelijne Anciaux, Mathieu Bollen, Cristiana Stefan, Dirk Roymans

Publikováno v: Journal of neurochemistry

The presence of a nucleotide pyrophosphatase (EC 3.6.1.9) on the plasma membrane of rat C6 glioma has been demonstrated by analysis of the hydrolysis of ATP labeled in the base and in the alpha- and gamma-phosphates. The enzyme degraded ATP into AMP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698b85a9bde964dfe4742a9725d67689
https://doi.org/10.1046/j.1471-4159.1999.0720826.x

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Brain levels and acetylcholinesterase inhibition with galantamine and donepezil in rats, mice, and rabbits

Autor: Sohel Sachak, Pierre-Olivier Guillaumat, Hugo Geerts, Wilhelmina Bode, Katelijne Anciaux, Christopher Grantham

Publikováno v: Brain research. 1033(2)

Galantamine is a rather weak acetylcholinesterase (AChE) inhibitor, currently approved for the symptomatic treatment of Alzheimer's disease, with possible additional allosteric potentiating effects at the nicotinic ACh receptor (nAChR). Earlier data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57ba1ce066c315a727f09bd1771ebe5
https://pubmed.ncbi.nlm.nih.gov/15694923

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Cyclic AMP-mediated induction of the glial fibrillary acidic protein is independent of protein kinase A activation in rat C6 glioma

Autor: Stefan Nicolai, Els Van Mechelen, Herman Slegers, Kristof Van Dommelen, Katelijne Anciaux

Publikováno v: Journal of neuroscience research

N6-O′2-dibutyryl cAMP (dbcAMP), N6-monobutyryl cAMP (N6-mbcAMP), 8-Chloro cAMP (ClcAMP), and O′2-monobutyryl cAMP (O′2-mbcAMP) were used to study glial fibrillary acidic protein (GFAP) induction in rat C6 glioma. With the exception of O′2-mbc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a527d0529f05d9a4a3078d7e3b74df5
https://pubmed.ncbi.nlm.nih.gov/9169858

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Inhibition of nucleoside diphosphate kinase (NDPK/nm23) by cAMP analogues

Autor: Herman Slegers, Dirk Roymans, Roel Willems, Kristof Van Dommelen, Katelijne Anciaux

Publikováno v: FEBS letters: for the rapid publication of short reports in biochemistry, biophysics and molecular biology

Nucleoside diphosphate kinase (NDPK/nm23) ATP/ GDP phosphotransferase activity and serine autophosphoryla- tion is inhibited by M-mbcAMP, 8-ClcAMP and 8-BrcAMP. Inhibition of the enzymatic activity largely depends on the concentration of ATP and beco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93f79d57405d0fa72cddb003e5c05de
https://hdl.handle.net/10067/191920151162165141

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