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of 2
pro vyhledávání: '"Kate Vignali"'
Autor:
Angela Marie Gocher, Jian Cui, Andrea Szymczak-Workman, Kate Vignali, Julianna N Latini, Gwen P Pieklo, Lyndsay Avery, Ellyse L Cipolla, Brydie R Huckestein, Lee Hedden, Marlies Meisel, John F Alcorn, Lawrence P Kane, Creg J. Workman, Dario A. A. Vignali
Publikováno v:
The Journal of Immunology. 208:53.23-53.23
Regulatory T cells (Tregs) are an immunosuppressive cell population that inhibits immune cell function to maintain peripheral tolerance and homeostasis. We have previously shown that Treg-- response to interferon gamma (IFNγ) is required for respons
Autor:
Creg Workman, Cliff Guy, Diana Mitrea, Po-Chien Chou, Jamshid Temirov, Kate Vignali, Xueyan Liu, Hui Zhang, Richard Kriwacki, Marcel Bruchez, Simon Watkins, Dario Vignali
Publikováno v:
The Journal of Immunology. 204:80.9-80.9
Lymphocyte activation gene 3 (LAG3) is an inhibitory receptor that is highly expressed on exhausted T cells in the tumor microenvironment. Despite over ten LAG3-targeting immunotherapeutics in clinical trials, we still do not know how LAG3 mediates i