Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire

Autor: Dawn Nicoll, Hugh J. Willison, Masaaki Odaka, Koichi Furukawa, Eric R. Wagner, Kate Townson, Joe Conner, Judith Boffey, Tyrone Bowes

Publikováno v: Journal of Neuroimmunology. 165:92-103

Neuropathogenic murine antibodies reactive with terminal disialylgalactose epitopes are innate and preferentially encoded by the VH7183.3b gene. Here we have studied antibodies reactive with internal galactose-linked disialosyl epitopes and the termi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17235b8cf06ec0c1345bda9d492d15d0
https://doi.org/10.1016/j.jneuroim.2005.04.011

Synthesis of ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian-Barré syndrome

Autor: Hugh J. Willison, Chang-Chun Ling, David R. Bundle, Ping Zhang, Kate Townson, Søren M. Andersen

Publikováno v: Org. Biomol. Chem.. 2:1199-1212

Guillain-Barré syndrome is a postinfectious, autoimmune neuropathy resulting in neuromuscular paralysis. Auto-antibodies, often induced by bacterial infection, bind to human gangliosides possessing monosialoside and diasialoside epitopes and impair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fc585737a27c99ea5b9ecdb2bfdacb
https://doi.org/10.1039/b400029c

Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury

Autor: Frances M. Platt, Hugh J. Willison, Kate Townson, Anneliese O. Speak, Carl S. Goodyear, Kay N. Greenshields

Publikováno v: Journal of neuroimmunology. 203(1)

Autoimmune neuropathies are frequently associated with pathogenic anti-ganglioside antibodies targeting ganglioside-rich neuronal and glial membranes. The extent of injury is determined by the concentration of membrane ganglioside and thus reduction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e18174ead2b023782d3139c6db1577
https://pubmed.ncbi.nlm.nih.gov/18684516

Solid phase immunoadsorption for therapeutic and analytical studies on neuropathy-associated anti-GM1 antibodies

Autor: Hugh J. Willison, Daniela Arosio, Tatiana Antoine, Judith Boffey, David R. Bundle, Anna Bernardi, Neil W. Isaacs, Eric Samain, Sandro Sonnino, Ping Zhang, J. Veitch, Dawn Nicholl, Kate Townson

Publikováno v: Glycobiology (Oxf.) 17 (2007): 294–303. doi:10.1093/glycob/cwl074
info:cnr-pdr/source/autori:K. Townson; J. Boffey; D. Nicholl; J. Veitch; D. Bundle; P. Zhang; E. Samain; T. Antoine; A. Bernardi; D. Arosio; S. Sonnino; N. Isaacs; H.J. Willison/titolo:Solid phase immunoadsorption for therapeutic and analytical studies on neuropathy-associated anti-GM1 antibodies/doi:10.1093%2Fglycob%2Fcwl074/rivista:Glycobiology (Oxf.)/anno:2007/pagina_da:294/pagina_a:303/intervallo_pagine:294–303/volume:17
Glycobiology
Glycobiology, Oxford University Press (OUP), 2007, pp.294-303

Autoimmune neuropathies including Guillain-Barre syndrome are frequently associated with anti-GM1 ganglioside antibodies. These are believed to play a pathogenic role and their clearance from the circulation would be predicted to produce therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42c18b851f0c247fedc75a659db4baf

Synthetic disialylgalactose immunoadsorbents deplete anti‐GQ1b antibodies from autoimmune neuropathy sera.

Autor: Hugh J. Willison, Kate Townson, Jean Veitch, Judith Boffey, Neil Isaacs, Soren M. Andersen, Ping Zhang, Chang‐Chun Ling, David R. Bundle

Publikováno v: Brain: A Journal of Neurology; Number 3 March, 2004, Vol. 127 Issue 3, p680-691, 12p