Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Kate Sponagle"'
1
The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels
Autor: Robert R. Montgomery, Boonchai Boonyawat, Kate Sponagle, Laura L. Swystun, Paula D. James, Colleen Notley, Natalia Rydz, David Lillicrap, Andrew D. Paterson, J. Jacob Riches
Publikováno v: Blood
Genetic variation in or near the C-type lectin domain family 4 member M (CLEC4M) has been associated with plasma levels of von Willebrand factor (VWF) in healthy individuals. CLEC4M is a lectin receptor with a polymorphic extracellular neck region po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36433547ed2f776efedf6f7833da094
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2
Pathologic mechanisms of type 1 VWD mutations R1205H and Y1584C through in vitro and in vivo mouse models
Autor: Andrea Bryant, Sandra L. Haberichter, Mia Golder, Kate Sponagle, Cynthia M. Pruss, Kimberly Laverty, Erin Burnett, Colleen Notley, Carol Hegadorn, David Lillicrap, Aly S. Dhala
Publikováno v: Blood. 117:4358-4366
Type 1 VWD is the mild to moderate reduction of VWF levels. This study examined the mechanisms underlying 2 common type 1 VWD mutations, the severe R1205H and more moderate Y1584C. In vitro biosynthesis was reduced for both mutations in human and mou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecfb378aa6cc3327c1d5e08922993e43
https://doi.org/10.1182/blood-2010-08-303727
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3
Mutation-specific hemostatic variability in mice expressing common type 2B von Willebrand disease substitutions
Autor: Kimberly Laverty, Kate Sponagle, David Lillicrap, Mia Golder, Cynthia M. Pruss, Jeffrey Mewburn, Carol Hegadorn
Publikováno v: Blood. 115:4862-4869
Type 2B von Willebrand disease (2B VWD) results from von Willebrand factor (VWF) A1 mutations that enhance VWF-GPIbα binding. These “gain of function” mutations lead to an increased affinity of the mutant VWF for platelets and the binding of mut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26370cf026bfabf3ede805db30739025
https://doi.org/10.1182/blood-2009-11-253120
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4
Concurrent influenza vaccination reduces anti-FVIII antibody responses in murine hemophilia A
Autor: Kate Sponagle, Jesse D. Lai, Christine Hough, Birgit M. Reipert, Paul Moorehead, Katharina Nora Steinitz, David Lillicrap
Publikováno v: Blood. 127(26)
Inflammatory signals such as pathogen- and danger-associated molecular patterns have been hypothesized as risk factors for the initiation of the anti-factor VIII (FVIII) immune response seen in 25% to 30% of patients with severe hemophilia A (HA). In
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b1ac16246e4a5c120c6b6ff21d59cd
https://pubmed.ncbi.nlm.nih.gov/27034428
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5
Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation
Autor: Barbara Vidal, Yasuaki Shida, Kate Sponagle, David Lillicrap, Ozge Danisment, Carol Hegadorn, Jeffrey Mewburn, David Stegner, Cynthia M. Pruss, Christine Brown, Bredon Crawford, Natalia Rydz, Bernhard Nieswandt
Publikováno v: Blood. 124(11)
Rare missense mutations in the von Willebrand factor (VWF) A3 domain that disrupt collagen binding have been found in patients with a mild bleeding phenotype. However, the analysis of these aberrant VWF-collagen interactions has been limited. Here, w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1025a03f3061957a2d5a7ca94859c8
https://pubmed.ncbi.nlm.nih.gov/25051961
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7
Immunization Against Influenza but Not MMR Modulates the Anti-Factor VIII Immune Response in Hemophilia Α Mice
Autor: Jesse D. Lai, Kate Sponagle, Christine Hough, Birgit M. Reipert, Katharina Nora Steinitz, David Lillicrap, Paul Moorehead
Publikováno v: Blood. 124:1501-1501
Introduction: The etiology of inhibitory factor VIII (FVIII) antibodies in 25-30% of hemophilia A (HA) patients remains poorly understood. It is possible that concurrent exposure to inflammatory stimuli, or ‘danger signals’, with FVIII increases
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cadf17a6fc08a538a264188e9d979598
https://doi.org/10.1182/blood.v124.21.1501.1501
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8
Characterization of Type 2N Von Willebrand Disease Mutations Using Ιn Vitro and Ιn Vivo Mouse Models
Autor: Kate Sponagle, Christine Brown, Mia Golder, Colleen Notley, Ilinca Georgescu, Laura L. Swystun, Meghan Deforest, David Lillicrap
Publikováno v: Blood. 124:471-471
Introduction: Von Willebrand factor (VWF) is a multimeric glycoprotein that serves as the carrier for the essential coagulation cofactor, factor VIII (FVIII). Both plasma levels of VWF and its FVIII-binding ability can influence plasma levels of FVII
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57972b3a6fad075f797edca1f55d8634
https://doi.org/10.1182/blood.v124.21.471.471
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9
Histones Induce Endothelial Von Willebrand Factor Release and Subsequent Platelet Capture in In Vitro and In Vivo Models
Autor: David Lillicrap, Kate Sponagle, Laura L. Swystun, Jeffrey Mewburn, Silvia Albánez, Alison Michels
Publikováno v: Blood. 124:2768-2768
Thrombosis is the leading cause of mortality worldwide and can result from uncontrolled immune activation in inflammatory conditions. Von Willebrand factor (VWF) is an acute phase glycoprotein that mediates primary hemostasis by binding to platelets.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::678e5172c1d0f82f196baa4b2a4ba747
https://doi.org/10.1182/blood.v124.21.2768.2768
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