Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Kate R. Secombe"'
Autor:
Elise E. Crame, Joanne M. Bowen, Kate R. Secombe, Janet K. Coller, Maxime François, Wayne Leifert, Hannah R. Wardill
Publikováno v:
Inflammatory Intestinal Diseases, Pp 1-11 (2021)
Introduction: Toll-like receptor 4 (TLR4) is a highly conserved immunosurveillance protein of innate immunity, displaying well-established roles in homeostasis and intestinal inflammation. Current evidence shows complex relationships between TLR4 act
Externí odkaz:
https://doaj.org/article/86b94b6a3d21484687c97bb9aae4b19d
Autor:
Kate R. Secombe, Imogen A. Ball, Anthony D. Wignall, Emma Bateman, Dorothy M. Keefe, Joanne M. Bowen
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 30, Iss , Pp 100806- (2022)
Background: Neratinib is a pan-ErbB tyrosine kinase inhibitor used for extended adjuvant treatment of HER2-positive breast cancer. Diarrhea is the main adverse event associated with neratinib treatment. We aimed here to determine whether antibiotic-i
Externí odkaz:
https://doaj.org/article/7e1901768b1942179f5a95af6966271e
Autor:
Ghanyah H. Al-Qadami, Kate R. Secombe, Courtney B. Subramaniam, Hannah R. Wardill, Joanne M. Bowen
Publikováno v:
Microorganisms, Vol 10, Iss 10, p 2048 (2022)
The gut microbiota has emerged as a key modulator of cancer treatment responses in terms of both efficacy and toxicity. This effect is clearly mediated by processes impacting the activation and modulation of immune responses. More recently, the abili
Externí odkaz:
https://doaj.org/article/15c28d0bde84402f87bda4550a52715a
Autor:
Kate R. Secombe, Ghanyah H. Al-Qadami, Courtney B. Subramaniam, Joanne M. Bowen, Jacqui Scott, Ysabella Z.A. Van Sebille, Matthew Snelson, Caitlin Cowan, Gerard Clarke, Cassandra E. Gheorghe, John F. Cryan, Hannah R. Wardill
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Fecal microbiota transplant (FMT) is a powerful tool used to connect changes in gut microbial composition with a variety of disease states and pathologies. While FMT enables potential causal relationships to be identified, the experimental details re
Externí odkaz:
https://doaj.org/article/19698be883f04b589aaa67518de4a882
Autor:
Kate R. Secombe BHSc (Hons), Ysabella Z. A. Van Sebille PhD, Bronwen J. Mayo PhD, Janet K. Coller PhD, Rachel J. Gibson PhD, Joanne M. Bowen PhD
Publikováno v:
Integrative Cancer Therapies, Vol 19 (2020)
Small molecule receptor tyrosine kinase inhibitors (SM-TKIs) are among a group of targeted cancer therapies, intended to be more specific to cancer cells compared with treatments, such as chemotherapy, hence reducing adverse events. Unfortunately, ma
Externí odkaz:
https://doaj.org/article/7ec33cd2800a42e8828cc2fbaafe97e5
Autor:
Samantha K. Korver, Joanne M. Bowen, Rachel J. Gibson, Imogen A. Ball, Kate R. Secombe, Taylor J. Wain, Richard M. Logan, Jonathan Tuke, Kelly R. Mead, Alison M. Richards, Christos S. Karapetis, Dorothy M. Keefe, Janet K. Coller
Publikováno v:
Cancer Chemotherapy and Pharmacology. 91:507-521
Purpose Adverse effects following fluoropyrimidine-based chemotherapy regimens are common. However, there are no current accepted diagnostic markers for prediction prior to treatment, and the underlying mechanisms remain unclear. This study aimed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::772c46358ec18fb3e56d64ec84b6d1b0
https://doi.org/10.1007/s00280-023-04538-3
https://doi.org/10.1007/s00280-023-04538-3
Autor:
Rachel J. Gibson, Elise E. Crame, Janine S. Y. Tam, Kate R. Secombe, Janet K. Coller, Hannah R. Wardill, Joanne M. Bowen
Publikováno v:
Cancer Chemotherapy and Pharmacology. 89:275-281
PURPOSE Irinotecan can cause high levels of diarrhea caused by toxic injury to the gastrointestinal microenvironment. Toll-like receptor 4 (TLR4) and the gut microbiome have previously been implicated in gastrointestinal toxicity and diarrhea; howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::703af78b13d9a8b79aaf4083ecf41b3a
https://doi.org/10.1007/s00280-021-04382-3
https://doi.org/10.1007/s00280-021-04382-3
Autor:
Janet K. Coller, Elise E. Crame, Wayne R. Leifert, Joanne M. Bowen, Maxime François, Hannah R. Wardill, Kate R. Secombe
Publikováno v:
Inflammatory Intestinal Diseases, Pp 1-11 (2021)
Inflamm Intest Dis
Inflamm Intest Dis
Introduction: Toll-like receptor 4 (TLR4) is a highly conserved immunosurveillance protein of innate immunity, displaying well-established roles in homeostasis and intestinal inflammation. Current evidence shows complex relationships between TLR4 act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5479c95029a5470aaa81ad7dd371d191
https://www.karger.com/Article/FullText/519200
https://www.karger.com/Article/FullText/519200
Autor:
Kate R, Secombe, Elise E, Crame, Janine S Y, Tam, Hannah R, Wardill, Rachel J, Gibson, Janet K, Coller, Joanne M, Bowen
Publikováno v:
Cancer chemotherapy and pharmacology. 89(2)
Irinotecan can cause high levels of diarrhea caused by toxic injury to the gastrointestinal microenvironment. Toll-like receptor 4 (TLR4) and the gut microbiome have previously been implicated in gastrointestinal toxicity and diarrhea; however, the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fdd5d523da37eb936f6d7017d8a338ef
https://pubmed.ncbi.nlm.nih.gov/34854953
https://pubmed.ncbi.nlm.nih.gov/34854953
Publikováno v:
International Journal of Cancer. 144(10):2365-2376
Chemotherapy‐induced gastrointestinal toxicity (CIGT) occurs in up to 80% of all patients undergoing cancer treatment, and leads to symptoms such as diarrhoea, abdominal bleeding and pain. There is currently limited understanding of how to predict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad6658f093312cb8e62e3066c7fdaea
https://hdl.handle.net/11370/90e0314a-cefa-44cf-8c4c-80544afbd41e
https://hdl.handle.net/11370/90e0314a-cefa-44cf-8c4c-80544afbd41e