Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kate M. Smith"'
Autor:
Thilini S. Munasinghe, Megan R. Edwards, Sofiya Tsimbalyuk, Olivia A. Vogel, Kate M. Smith, Murray Stewart, Justin K. Foster, Loretta A. Bosence, David Aragão, Justin A. Roby, Christopher F. Basler, Jade K. Forwood
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
MERS-CoV ORF4b antagonizes host innate immune response, partially via blocking nuclear import adapter IMPα activity and preventing nuclear translocation of NF-κB. Here, Munasinghe and Edwards et al. biochemically and structurally define the interac
Externí odkaz:
https://doaj.org/article/24c49199db9a4db7bb2d31b55376fd00
Autor:
Kate M. Smith, Sofiya Tsimbalyuk, Megan R. Edwards, Emily M. Cross, Jyoti Batra, Tatiana P. Soares da Costa, David Aragão, Christopher F. Basler, Jade K. Forwood
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Importin α isoforms regulate the nuclear import of different cargo proteins but the mechanisms conferring isoform specificity are not fully understood. Here, the authors study the interactions of importin α1 and α3 with two viral cargos, elucidati
Externí odkaz:
https://doaj.org/article/2c7181d38279433e819e86bdf827aea6
Autor:
Jonathan R. Brody, Allan M. Jordan, Dominic I. James, Donald Ogilvie, Michael J. Pishvaian, Talia Golan, Kenneth P. Olive, Jordan M. Winter, Charles J. Yeo, Dikla Atias, Yulia Glick Gorman, Chani Stossel, Maria Raitses-Gurevich, Ian D. Waddell, Kate M. Smith, Cinthya Yabar Lowder, Christopher W. Schultz, Joseph Cozzitorto, Avinoam Nevler, AnnJosette Ramirez, Saswati N. Chand, Grace A. McCarthy, Lebaron C. Agostini, Aditi Jain
Supplementary Fig S7 describes western blot and RTPCR of PARG in modified shPARG cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12baac012d9c7c055a7134059d275323
https://doi.org/10.1158/0008-5472.22421175
https://doi.org/10.1158/0008-5472.22421175
Autor:
Jonathan R. Brody, Allan M. Jordan, Dominic I. James, Donald Ogilvie, Michael J. Pishvaian, Talia Golan, Kenneth P. Olive, Jordan M. Winter, Charles J. Yeo, Dikla Atias, Yulia Glick Gorman, Chani Stossel, Maria Raitses-Gurevich, Ian D. Waddell, Kate M. Smith, Cinthya Yabar Lowder, Christopher W. Schultz, Joseph Cozzitorto, Avinoam Nevler, AnnJosette Ramirez, Saswati N. Chand, Grace A. McCarthy, Lebaron C. Agostini, Aditi Jain
Patients with metastatic pancreatic ductal adenocarcinoma (PDAC) have an average survival of less than 1 year, underscoring the importance of evaluating novel targets with matched targeted agents. We recently identified that poly (ADP) ribose glycohy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2caad1a0117fff7a23cc205bcb261f20
https://doi.org/10.1158/0008-5472.c.6510855.v1
https://doi.org/10.1158/0008-5472.c.6510855.v1
Autor:
Jonathan R. Brody, Allan M. Jordan, Dominic I. James, Donald Ogilvie, Michael J. Pishvaian, Talia Golan, Kenneth P. Olive, Jordan M. Winter, Charles J. Yeo, Dikla Atias, Yulia Glick Gorman, Chani Stossel, Maria Raitses-Gurevich, Ian D. Waddell, Kate M. Smith, Cinthya Yabar Lowder, Christopher W. Schultz, Joseph Cozzitorto, Avinoam Nevler, AnnJosette Ramirez, Saswati N. Chand, Grace A. McCarthy, Lebaron C. Agostini, Aditi Jain
Supplementary Table 1 describes BRCA and KRAS status of PDX models and IC50 of PDDX-001 and olaparib in PDAC/PDX lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026a9815acebb66132a058861657f64e
https://doi.org/10.1158/0008-5472.22421172
https://doi.org/10.1158/0008-5472.22421172
Autor:
Ann Josette Ramirez, Talia Golan, Yulia Glick Gorman, Grace A. McCarthy, Dominic I. James, Maria Raitses-Gurevich, Avinoam Nevler, Jordan M. Winter, Dikla Atias, Michael J. Pishvaian, Chani Stossel, Joseph A. Cozzitorto, Kate M. Smith, Christopher W. Schultz, Kenneth P. Olive, Lebaron C. Agostini, Donald J. Ogilvie, Cinthya Y. Lowder, Aditi Jain, Charles J. Yeo, Saswati N. Chand, Jonathan R. Brody, Allan M. Jordan, Ian D. Waddell
Publikováno v:
Cancer Research. 79:4491-4502
Patients with metastatic pancreatic ductal adenocarcinoma (PDAC) have an average survival of less than 1 year, underscoring the importance of evaluating novel targets with matched targeted agents. We recently identified that poly (ADP) ribose glycohy
Autor:
Yanhao Lai, Kate M. Smith, Dominic I. James, Judy L. Vasquez, Irina U. Agoulnik, Manqi Zhang, Ian D. Waddell, Donald J. Ogilvie, Yuan Liu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
There is mounting evidence of androgen receptor signaling inducing genome instability and changing DNA repair capacity in prostate cancer cells. Expression of genes associated with base excision repair (BER) is increased with prostate cancer progress
Autor:
Ian D. Waddell, Robert W. Sobol, Kate M. Smith, Justin L. Roncaioli, Felipe da Veiga Leprevost, Song My Hoang, Dattatreya Mellacharevu, Dominique Ray-Gallet, Michelle L. Lynskey, Roderick J. O’Sullivan, Ragini Bhargava, Jonathan Barroso-González, Nicole Kaminski, Geneviève Almouzni, Anne R. Wondisford, Jianfeng Li, Donald J. Ogilvie, Alexey I. Nesvizhskii, Dominic I. James, Callen T. Wallace, Simon C. Watkins, Laura García-Expósito
Publikováno v:
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, Nature Publishing Group, 2020, 27 (12), pp.1152-1164. ⟨10.1038/s41594-020-0512-7⟩
Nature Structural & Molecular Biology
Nature Structural and Molecular Biology, 2020, 27 (12), pp.1152-1164. ⟨10.1038/s41594-020-0512-7⟩
Nat Struct Mol Biol
Nature Structural and Molecular Biology, Nature Publishing Group, 2020, 27 (12), pp.1152-1164. ⟨10.1038/s41594-020-0512-7⟩
Nature Structural & Molecular Biology
Nature Structural and Molecular Biology, 2020, 27 (12), pp.1152-1164. ⟨10.1038/s41594-020-0512-7⟩
Nat Struct Mol Biol
International audience; The synthesis of poly(ADP-ribose) (PAR) reconfigures the local chromatin environment and recruits DNA-repair complexes to damaged chromatin. PAR degradation by poly(ADP-ribose) glycohydrolase (PARG) is essential for progressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d45f0c33f255ca7323659e74359498
https://hal.sorbonne-universite.fr/hal-03138406
https://hal.sorbonne-universite.fr/hal-03138406
Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure
Autor:
Ben, Acton, Helen F, Small, Kate M, Smith, Alison, McGonagle, Alexandra I J, Stowell, Dominic I, James, Niall M, Hamilton, Nicola, Hamilton, James R, Hitchin, Colin P, Hutton, Ian D, Waddell, Donald J, Ogilvie, Allan M, Jordan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Fluorination of metabolic hotspots in a molecule is a common medicinal chemistry strategy to improve in vivo half-life and exposure and, generally, this strategy offers significant benefits. Here, we report the application of
Fluorination of metabolic hotspots in a molecule is a common medicinal chemistry strategy to improve in vivo half-life and exposure and, generally, this strategy offers significant benefits. Here, we report the application of
Autor:
Julie A. Tucker, Ben Acton, Ian D. Waddell, Alexandra Stowell, Nicola Hamilton, Niall M. Hamilton, Kate M. Smith, Stuart Donald Jones, James R. Hitchin, Bohdan Waszkowycz, Alison E. McGonagle, Dominic I. James, Allan M. Jordan, Daniel P. Mould, Clifford David Jones, Colin Hutton, Helen F. Small, Emma E. Fairweather, Donald J. Ogilvie, Louise A. Griffiths
Publikováno v:
Waszkowycz, B, Smith, K, Mcgonagle, A, Jordan, A, Acton, B, Fairweather, E, Griffiths, L, Hamilton, N M, Hamilton, N, Hitchin, J R, Hutton, C, James, D I, Jones, C D, Jones, S, Mould, D, Small, H F, Stowell, A, Tucker, J, Waddell, I & Ogilvie, D J 2018, ' Cell-active Small Molecule Inhibitors of the DNA-damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides ', Journal of Medicinal Chemistry, vol. 61, no. 23, pp. 10767–10792 . https://doi.org/10.1021/acs.jmedchem.8b01407
DNA damage repair enzymes are promising targets in the development of new therapeutic agents for a wide range of cancers and potentially other diseases. The enzyme poly(ADP-ribose) glycohydrolase (PARG) plays a pivotal role in the regulation of DNA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e713bd6a754c7026f2f63ab3b3df4e2
https://doi.org/10.1021/acs.jmedchem.8b01407
https://doi.org/10.1021/acs.jmedchem.8b01407