Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kate M. O'Connor-Giles"'
Autor:
Kendall M. Hoover, Scott J. Gratz, Nova Qi, Kelsey A. Herrmann, Yizhou Liu, Jahci J. Perry-Richardson, Pamela J. Vanderzalm, Kate M. O’Connor-Giles, Heather T. Broihier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Activity-dependent pathways are important for synapse function but the molecular links to synapse function are not clear. The authors show that the Ca2 + channel subunit α2δ-3 provides an extracellular scaffold for autocrine BMP signalling at the D
Externí odkaz:
https://doaj.org/article/a1043f4b84eb401ca0ba1c3cdf432be5
Publikováno v:
eLife, Vol 12 (2024)
Synaptic heterogeneity is a hallmark of nervous systems that enables complex and adaptable communication in neural circuits. To understand circuit function, it is thus critical to determine the factors that contribute to the functional diversity of s
Externí odkaz:
https://doaj.org/article/d58d6cd12aaa4570b7a5d9353593b7e3
Publikováno v:
bioRxiv
Synaptic heterogeneity is a hallmark of complex nervous systems that enables reliable and responsive communication in neural circuits. In this study, we investigated the contributions of voltage-gated calcium channels (VGCCs) to synaptic heterogeneit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5092aeb6658429addb648b75755426a7
https://doi.org/10.1101/2023.04.02.535290
https://doi.org/10.1101/2023.04.02.535290
Autor:
C.A. Hogan, S.J. Gratz, J.L. Dumouchel, A. Delgado, J.M. Lentini, K.R. Madhwani, R.S. Thakur, D. Fu, Kate M. O’Connor-Giles
Nervous system function relies on the formation and function of synaptic connections between neurons. Through a genetic screen inDrosophilafor new conserved synaptic genes, we identified CG42261/Fid/ TRMT9B as a negative regulator of synaptogenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::196c4b868099cc2f4b9bc1c7086d0664
https://doi.org/10.1101/2022.12.30.522321
https://doi.org/10.1101/2022.12.30.522321
Autor:
Diego Calderon, Ronnie Blecher-Gonen, Xingfan Huang, Stefano Secchia, James Kentro, Riza M. Daza, Beth Martin, Alessandro Dulja, Christoph Schaub, Cole Trapnell, Erica Larschan, Kate M. O’Connor-Giles, Eileen E. M. Furlong, Jay Shendure
Publikováno v:
Science. 377
Drosophila melanogaster is a powerful, long-standing model for metazoan development and gene regulation. We profiled chromatin accessibility in almost 1 million and gene expression in half a million nuclei from overlapping windows spanning the entire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56539cb81160ed6bd6b11bb4ab6ec7c8
https://doi.org/10.1126/science.abn5800
https://doi.org/10.1126/science.abn5800
Autor:
Diego, Calderon, Ronnie, Blecher-Gonen, Xingfan, Huang, Stefano, Secchia, James, Kentro, Riza M, Daza, Beth, Martin, Alessandro, Dulja, Christoph, Schaub, Cole, Trapnell, Erica, Larschan, Kate M, O'Connor-Giles, Eileen E M, Furlong, Jay, Shendure
Publikováno v:
Science (New York, N.Y.). 377(6606)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6882e9611563ac6ec0d2f479466e7a9
https://pubmed.ncbi.nlm.nih.gov/35926038
https://pubmed.ncbi.nlm.nih.gov/35926038
Publikováno v:
Fly, Vol 7, Iss 4, Pp 249-255 (2013)
The CRISPR/Cas9 system has attracted significant attention for its potential to transform genome engineering. We and others have recently shown that the RNA-guided Cas9 nuclease can be employed to engineer the Drosophila genome, and that these modifi
Externí odkaz:
https://doaj.org/article/59373ac1a0ea46e3bb7faba4d028c93c
Autor:
Judith Kimble, William M Bement, Qiang Chang, Benjamin L Cox, Norman R Drinkwater, Richard L Gourse, Aaron A Hoskins, Anna Huttenlocher, Pamela K Kreeger, Paul F Lambert, Marsha R Mailick, Shigeki Miyamoto, Richard L Moss, Kate M O'Connor-Giles, Avtar Roopra, Krishanu Saha, Hannah S Seidel
Publikováno v:
eLife, Vol 4 (2015)
A cross-campus, cross-career stage and cross-disciplinary series of discussions at a large public university has produced a series of recommendations for addressing the problems confronting the biomedical research community in the US.
Externí odkaz:
https://doaj.org/article/977f332b05b245bbb249d515b2ab0389
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
Synapses are the fundamental functional units of neural circuits, and their dysregulation has been implicated in diverse neurological disorders. At presynaptic terminals, neurotransmitter-filled synaptic vesicles are released in response to calcium i
Externí odkaz:
https://doaj.org/article/d9d23f5535914c30975ec63330321692
Publikováno v:
Genetics
Genetics, vol 208, iss 1
Genetics, vol 208, iss 1
Drosophila has long been a premier model for the development and application of cutting-edge genetic approaches. The CRISPR-Cas system now adds the ability to manipulate the genome with ease and precision, providing a rich toolbox to interrogate rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc618b1058f01f333d32788ed8375a6c
http://europepmc.org/articles/PMC5753851
http://europepmc.org/articles/PMC5753851