Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kate L. Lee"'
Autor:
Emma J. Buckels, Joey Tan, Huai‐Ling Hsu, Yuting Zhu, Christina M. Buchanan, Brya G. Matthews, Kate L. Lee
Publikováno v:
JBMR Plus, Vol 7, Iss 8, Pp n/a-n/a (2023)
ABSTRACT Preptin is derived from the cleavage of the E‐peptide of pro‐insulin‐like growth factor (IGF)‐II and is an insulin secretagogue. Observational studies have linked elevated circulating preptin to metabolic dysfunction in humans; howev
Externí odkaz:
https://doaj.org/article/881df186734f4c5883a47775a23c16b9
Publikováno v:
Biomolecules, Vol 9, Iss 9, p 402 (2019)
The hyper-activation of the phosphoinositide (PI) 3-kinase signaling pathway is a hallmark of many cancers and overgrowth syndromes, and as a result, there has been intense interest in the development of drugs that target the various isoforms of PI 3
Externí odkaz:
https://doaj.org/article/d35be7d33e0e4e269b4395061a0f9092
Autor:
Shalinda J.A. Fernando, Qian Wang, Debbie L. Hay, Ross A.D. Bathgate, Peter R. Shepherd, Kate L. Lee
Publikováno v:
Bioscience Reports. 43
RXFP4 is a G protein–coupled receptor (GPCR) in the relaxin family. It has recently been recognised that this receptor and its cognate ligand INSL5 may have a role in the regulation of food intake, gut motility, and other functions relevant to meta
Autor:
Geoffrey M. Williams, Margaret A. Brimble, Jacqueline F. Aitken, Kirsten Montgomery, Kate L. Lee, Xun Li, Garth J. S. Cooper, Huai-L Hsu
Publikováno v:
Islets
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Pancreatic islet-cell function and volume are both key determinants of the maintenance of metabolic health. Insulin resistance and islet-cell dysfunction often occur in the earlier stages of type 2 diabetes (T2D) progression. The ability of the islet
Autor:
Prasanna Kallingappa, Tony R. Merriman, Hannah J. Burden, Braydon Kulatea, Kate L. Lee, Lindsay D. Plank, Danielle Sword, Rosemary M. Hall, Morag Wright-McNaughton, Troy L. Merry, Conor Watene-O’Sullivan, Jeremy D. Krebs, Rinki Murphy, Robert D. Atiola, Phillip Wilcox, Sanaz Vakili, Ryan G. Paul, Shannon Adams, Greg C. Smith, Peter R. Shepherd
The minor allele (A) of the rs373863828 variant (p.Arg457Gln) in CREBRF is restricted to indigenous peoples of the Pacific islands (including New Zealand Māori and peoples of Polynesia), with a frequency up to 25% in these populations. This allele a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17b42d438893c7954c83a8baf93864ac
https://doi.org/10.1101/2021.07.13.21260462
https://doi.org/10.1101/2021.07.13.21260462
Autor:
Geoffrey M. Williams, Garth J. S. Cooper, Kate L. Lee, Margaret A. Brimble, Huai L. Hsu, Jacqueline F. Aitken
Publikováno v:
Peptides. 116:1-7
Pancreatic islet-derived peptide hormones play key roles in the maintenance of systemic energy homeostasis and glucose balance and defects in their regulation are strongly implicated in the pathogenesis of obesity and diabetes. Peptides have also bee
Publikováno v:
The Biochemical journal. 478(8)
The presence of adherens junctions and the associated protein β-catenin are requirements for the development of glucose-stimulated insulin secretion (GSIS) in β-cells. Evidence indicates that modulation of β-catenin function in response to changes
Autor:
Nour H. AlSaud, Marta P. Silvestre, Anne Raben, Mikael Fogelholm, Sally D. Poppitt, Kate L. Lee
Publikováno v:
Obesity researchclinical practice. 15(1)
Background Weight reduction is effective in preventing T2D however, weight reduction and maintenance is difficult to achieve on a population scale. Serum insulin-like growth factor II (IGF-II) and IGF-II receptor (IGF2R) have been associated with dia
Publikováno v:
Biochemical Journal
The recent finding that β-catenin levels play an important rate-limiting role in processes regulating insulin secretion lead us to investigate whether its binding partner α-catenin also plays a role in this process. We find that levels of both α-E
Publikováno v:
Biomolecules, Vol 9, Iss 9, p 402 (2019)
Biomolecules
Biomolecules
The hyper-activation of the phosphoinositide (PI) 3-kinase signaling pathway is a hallmark of many cancers and overgrowth syndromes, and as a result, there has been intense interest in the development of drugs that target the various isoforms of PI 3