Výsledky vyhledávání - "Kate L. Henderson"

Temperature effects on RNA polymerase initiation kinetics reveal which open complex initiates and that bubble collapse is stepwise

Autor: Kate L. Henderson, Claire Evensen, Lindsey C. Felth, Irina A. Shkel, Cristen Molzahn, Dylan Plaskon, M. Thomas Record, Sarah Dyke

Publikováno v: Proc Natl Acad Sci U S A

Transcription initiation is highly regulated by promoter sequence, transcription factors, and ligands. All known transcription inhibitors, an important class of antibiotics, act in initiation. To understand regulation and inhibition, the biophysical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203f1b070b5f9bf512c233c15bd4ef1d
https://doi.org/10.1073/pnas.2021941118

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RNA Polymerase: Step-by-Step Kinetics and Mechanism of Transcription Initiation

Autor: Guanyu Liao, Irina A. Shkel, Claire Evensen, Kate L. Henderson, Lindsey C. Felth, Sarah Dyke, M. Thomas Record, Cristen Molzahn

Publikováno v: Biochemistry

To determine the step-by-step kinetics and mechanism of transcription initiation and escape by E. coli RNA polymerase from the λPR promoter, we quantify the accumulation and decay of transient short RNA intermediates on the pathway to promoter escap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a33d7c4eadfa53fd28e9a120fa27d2
https://doi.org/10.1021/acs.biochem.9b00049

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Kinetic-Mechanistic Evidence for Which E. coli RNA Polymerase-λPR Open Promoter Complex Initiates and for Stepwise Disruption of Contacts in Bubble Collapse

Autor: Kate L. Henderson, Sarah Dyke, Irina A. Shkel, Claire Evensen, Cristen Molzahn, Lindsey C. Felth, M. Thomas Record, Dylan Plaskon

In transcription initiation, specific contacts between RNA polymerase (RNAP) and promoter DNA are disrupted as the RNA-DNA hybrid advances into the cleft, resulting in escape of RNAP. From the pattern of large and small rate constants for steps of in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::287649487651eb36b82def82b04ae2ca
https://doi.org/10.1101/2020.09.11.293670

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The Irving–Williams series and the 2-His-1-carboxylate facial triad: a thermodynamic study of Mn2+, Fe2+, and Co2+ binding to taurine/α-ketoglutarate dioxygenase (TauD)

Autor: Robert P. Hausinger, Joseph P. Emerson, Mingjie Li, Salette Martinez, Kate L. Henderson

Publikováno v: JBIC Journal of Biological Inorganic Chemistry. 23:785-793

Taurine/α-ketoglutarate (αKG) dioxygenase (TauD) is an E. coli nonheme Fe2+- and αKG-dependent metalloenzyme that catalyzes the hydroxylation of taurine, leading to the production of sulfite. The metal-dependent active site in TauD is formed by tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88e137a5cfbf1863af371675d3b0c20d
https://doi.org/10.1007/s00775-018-1574-4

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Global stability of an α-ketoglutarate-dependent dioxygenase (TauD) and its related complexes

Autor: Robert P. Hausinger, Kate L. Henderson, Mingjie Li, Joseph P. Emerson, Salette Martinez, Edwin A. Lewis

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:987-994

Background TauD is a nonheme iron(II) and α-ketoglutarate (αKG) dependent dioxygenase, and a member of a broader family of enzymes that oxidatively decarboxylate αKG to succinate and carbon dioxide thereby activating O 2 to perform a range of oxid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bad3cc422711b7e6d3121fb2326bda
https://doi.org/10.1016/j.bbagen.2017.02.018

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LA-ICP-MS chemical analysis of archaeological otoliths as a tool for seasonality and site catchment studies

Autor: Kate L. Henderson, R. I. Gabitov, Carla S. Hadden, Evan Peacock, Jonathan R. Frisch, Bradley Carlock

Publikováno v: Journal of Archaeological Science. 65:11-19

Analysis of the trace element chemistry of otoliths via Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) has become common in fisheries-related work, allowing biologists to trace connectivity between habitats over the life cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56b8162edf35bd8f6c03e0c7b34a8336
https://doi.org/10.1016/j.jas.2015.10.009

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The Irving-Williams series and the 2-His-1-carboxylate facial triad: a thermodynamic study of Mn

Autor: Mingjie, Li, Kate L, Henderson, Salette, Martinez, Robert P, Hausinger, Joseph P, Emerson

Publikováno v: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 23(5)

Taurine/α-ketoglutarate (αKG) dioxygenase (TauD) is a nonheme Fe(2+) and αKG dependent metalloenzyme, which catalyzes the hydroxylation of taurine eventually leading to sulfite production in Escherichia coli. The metal-dependent active site in Tau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3283881c8ea6fdcf3012a9ecfd08beeb
https://pubmed.ncbi.nlm.nih.gov/29923040

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