Importin α4 deficiency induces psychiatric disorder-related behavioral deficits and neuroinflammation in mice

Autor: Koki Sakurai, Makiko Morita, Yoshiatsu Aomine, Mitsunobu Matsumoto, Tetsuji Moriyama, Emiko Kasahara, Atsuo Sekiyama, Mayumi Otani, Rieko Oshima, Kate L. Loveland, Masami Yamada, Yoshihiro Yoneda, Masahiro Oka, Takatoshi Hikida, Yoichi Miyamoto

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract Importin α4, which is encoded by the Kpna4 gene, is a well-characterized nuclear-cytoplasmic transport factor known to mediate transport of transcription factors including NF-κB. Here, we report that Kpna4 knock-out (KO) mice exhibit psych

Externí odkaz: https://doaj.org/article/0e444876e7134d318d7be770966169c1

Drosophila Importin Alpha 1 (Dα1) Is Required to Maintain Germline Stem Cells in the Testis Niche

Autor: James Heaney, Jiamin Zhao, Franca Casagranda, Kate L. Loveland, Nicole A. Siddall, Gary R. Hime

Publikováno v: Cells, Vol 13, Iss 6, p 494 (2024)

Stem cell maintenance and differentiation can be regulated via the differential activity of transcription factors within stem cells and their progeny. For these factors to be active, they need to be transported from their site of synthesis in the cyt

Externí odkaz: https://doaj.org/article/a8249005d3f44940b20e8942b5c8782c

Spermatogonial fate in mice with increased activin A bioactivity and testicular somatic cell tumours

Autor: Penny A. F. Whiley, Benedict Nathaniel, Peter G. Stanton, Robin M. Hobbs, Kate L. Loveland

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Adult male fertility depends on spermatogonial stem cells (SSCs) which undergo either self-renewal or differentiation in response to microenvironmental signals. Activin A acts on Sertoli and Leydig cells to regulate key aspects of testis development

Externí odkaz: https://doaj.org/article/0206b3d1ce1449d0bb1b99aa6426ecc0

Activin A and Sertoli Cells: Key to Fetal Testis Steroidogenesis

Autor: Liza O’Donnell, Penny A. F. Whiley, Kate L. Loveland

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

The long-standing knowledge that Sertoli cells determine fetal testosterone production levels is not widespread, despite being first reported over a decade ago in studies of mice. Hence any ongoing use of testosterone as a marker of Leydig cell funct

Externí odkaz: https://doaj.org/article/2dee3060aab44dd4a35f2277ff0e9862

Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology

Autor: Lars Björndahl, Christopher L R Barratt, David Mortimer, Ashok Agarwal, Robert J Aitken, Juan G Alvarez, Natalie Aneck-Hahn, Stefan Arver, Elisabetta Baldi, Lluís Bassas, Florence Boitrelle, Riana Bornman, Douglas T Carrell, José A Castilla, Gerardo Cerezo Parra, Jerome H Check, Patricia S Cuasnicu, Sally Perreault Darney, Christiaan de Jager, Christopher J De Jonge, Joël R Drevet, Erma Z Drobnis, Stefan S Du Plessis, Michael L Eisenberg, Sandro C Esteves, Evangelini A Evgeni, Alberto Ferlin, Nicolas Garrido, Aleksander Giwercman, Ilse G F Goovaerts, Trine B Haugen, Ralf Henkel, Lars Henningsohn, Marie-Claude Hofmann, James M Hotaling, Piotr Jedrzejczak, Pierre Jouannet, Niels Jørgensen, Jackson C Kirkman Brown, Csilla Krausz, Maciej Kurpisz, Ulrik Kvist, Dolores J Lamb, Hagai Levine, Kate L Loveland, Robert I McLachlan, Ali Mahran, Liana Maree, Sarah Martins da Silva, Michael T Mbizvo, Andreas Meinhardt, Roelof Menkveld, Sharon T Mortimer, Sergey Moskovtsev, Charles H Muller, Maria José Munuce, Monica Muratori, Craig Niederberger, Cristian O’Flaherty, Rafael Oliva, Willem Ombelet, Allan A Pacey, Michael A Palladino, Ranjith Ramasamy, Liliana Ramos, Nathalie Rives, Eduardo Rs Roldan, Susan Rothmann, Denny Sakkas, Andrea Salonia, Maria Cristina Sánchez-Pozo, Rosanna Sapiro, Stefan Schlatt, Peter N Schlegel, Hans-Christian Schuppe, Rupin Shah, Niels E Skakkebæk, Katja Teerds, Igor Toskin, Herman Tournaye, Paul J Turek, Gerhard van der Horst, Monica Vazquez-Levin, Christina Wang, Alex Wetzels, Theodosia Zeginiadou, Armand Zini

Publikováno v: HUMAN REPRODUCTION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Human Reproduction, 37, 2497-2502
Human Reproduction
Human Reproduction, 2022, 37 (11), pp.2497-2502. ⟨10.1093/humrep/deac189⟩
Björndahl, L, Barratt, C L R, Mortimer, D, Agarwal, A, Aitken, R J, Alvarez, J G, Aneck-Hahn, N, Arver, S, Baldi, E, Bassas, L, Boitrelle, F, Bornman, R, Carrell, D T, Castilla, J A, Cerezo Parra, G, Check, J H, Cuasnicu, P S, Darney, S P, de Jager, C, De Jonge, C J, Drevet, J R, Drobnis, E Z, Du Plessis, S S, Eisenberg, M L, Esteves, S C, Evgeni, E A, Ferlin, A, Garrido, N, Giwercman, A, Goovaerts, I G F, Haugen, T B, Henkel, R, Henningsohn, L, Hofmann, M C, Hotaling, J M, Jedrzejczak, P, Jouannet, P, Jørgensen, N, Kirkman Brown, J C, Krausz, C, Kurpisz, M, Kvist, U, Lamb, D J, Levine, H, Loveland, K L, McLachlan, R I, Mahran, A, Maree, L, Martins da Silva, S, Mbizvo, M T, Meinhardt, A, Menkveld, R, Mortimer, S T, Moskovtsev, S, Muller, C H, Munuce, M J, Muratori, M, Niederberger, C, O'Flaherty, C, Oliva, R, Ombelet, W, Pacey, A A, Palladino, M A, Ramasamy, R, Ramos, L, Rives, N, Roldan, E R, Rothmann, S, Sakkas, D, Salonia, A, Sánchez-Pozo, M C, Sapiro, R, Schlatt, S, Schlegel, P N, Schuppe, H C, Shah, R, Skakkebæk, N E, Teerds, K, Toskin, I, Tournaye, H, Turek, P J, van der Horst, G, Vazquez-Levin, M, Wang, C, Wetzels, A, Zeginiadou, T & Zini, A 2022, ' Standards in semen examination : publishing reproducible and reliable data based on high-quality methodology ', Human Reproduction, vol. 37, no. 11, pp. 2497-2502 . https://doi.org/10.1093/humrep/deac189
Human reproduction (Oxford, England) 37 (2022) 11
Human reproduction
Human reproduction (Oxford, England), 37(11), 2497-2502
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

Biomedical science is rapidly developing in terms of more transparency, openness and reproducibility of scientific publications. This is even more important for all studies that are based on results from basic semen examination. Recently two concorda

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7218b3fb5ad10d580776ec380f57e6bc
https://doi.org/10.1093/humrep/deac189