Importin α4 deficiency induces psychiatric disorder-related behavioral deficits and neuroinflammation in mice

Autor: Koki Sakurai, Makiko Morita, Yoshiatsu Aomine, Mitsunobu Matsumoto, Tetsuji Moriyama, Emiko Kasahara, Atsuo Sekiyama, Mayumi Otani, Rieko Oshima, Kate L. Loveland, Masami Yamada, Yoshihiro Yoneda, Masahiro Oka, Takatoshi Hikida, Yoichi Miyamoto

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract Importin α4, which is encoded by the Kpna4 gene, is a well-characterized nuclear-cytoplasmic transport factor known to mediate transport of transcription factors including NF-κB. Here, we report that Kpna4 knock-out (KO) mice exhibit psych

Externí odkaz: https://doaj.org/article/0e444876e7134d318d7be770966169c1

Spermatogonial fate in mice with increased activin A bioactivity and testicular somatic cell tumours

Autor: Penny A. F. Whiley, Benedict Nathaniel, Peter G. Stanton, Robin M. Hobbs, Kate L. Loveland

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Adult male fertility depends on spermatogonial stem cells (SSCs) which undergo either self-renewal or differentiation in response to microenvironmental signals. Activin A acts on Sertoli and Leydig cells to regulate key aspects of testis development

Externí odkaz: https://doaj.org/article/0206b3d1ce1449d0bb1b99aa6426ecc0

The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis

Autor: Christiane Pleuger, Dingding Ai, Minea L Hoppe, Laura T Winter, Daniel Bohnert, Dominik Karl, Stefan Guenther, Slava Epelman, Crystal Kantores, Monika Fijak, Sarina Ravens, Ralf Middendorff, Johannes U Mayer, Kate L Loveland, Mark Hedger, Sudhanshu Bhushan, Andreas Meinhardt

Publikováno v: eLife, Vol 11 (2022)

The epididymis functions as transition zone for post-testicular sperm maturation and storage and faces contrasting immunological challenges, i.e. tolerance towards spermatozoa vs. reactivity against pathogens. Thus, normal organ function and integrit

Externí odkaz: https://doaj.org/article/a41d07b05a714c4997aefbc4d9a009e5

The Impact of Activin A on Fetal Gonocytes: Chronic Versus Acute Exposure Outcomes

Autor: Sarah C. Moody, Penny A. F. Whiley, Patrick S. Western, Kate L. Loveland

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

Activin A, a TGFβ superfamily member, is important for normal testis development through its actions on Sertoli cell development. Our analyses of altered activin A mouse models indicated gonocyte abnormalities, implicating activin A as a key determi

Externí odkaz: https://doaj.org/article/1cca202fbcd24948b73ee09bf267d8a9

Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology

Autor: Lars Björndahl, Christopher L R Barratt, David Mortimer, Ashok Agarwal, Robert J Aitken, Juan G Alvarez, Natalie Aneck-Hahn, Stefan Arver, Elisabetta Baldi, Lluís Bassas, Florence Boitrelle, Riana Bornman, Douglas T Carrell, José A Castilla, Gerardo Cerezo Parra, Jerome H Check, Patricia S Cuasnicu, Sally Perreault Darney, Christiaan de Jager, Christopher J De Jonge, Joël R Drevet, Erma Z Drobnis, Stefan S Du Plessis, Michael L Eisenberg, Sandro C Esteves, Evangelini A Evgeni, Alberto Ferlin, Nicolas Garrido, Aleksander Giwercman, Ilse G F Goovaerts, Trine B Haugen, Ralf Henkel, Lars Henningsohn, Marie-Claude Hofmann, James M Hotaling, Piotr Jedrzejczak, Pierre Jouannet, Niels Jørgensen, Jackson C Kirkman Brown, Csilla Krausz, Maciej Kurpisz, Ulrik Kvist, Dolores J Lamb, Hagai Levine, Kate L Loveland, Robert I McLachlan, Ali Mahran, Liana Maree, Sarah Martins da Silva, Michael T Mbizvo, Andreas Meinhardt, Roelof Menkveld, Sharon T Mortimer, Sergey Moskovtsev, Charles H Muller, Maria José Munuce, Monica Muratori, Craig Niederberger, Cristian O’Flaherty, Rafael Oliva, Willem Ombelet, Allan A Pacey, Michael A Palladino, Ranjith Ramasamy, Liliana Ramos, Nathalie Rives, Eduardo Rs Roldan, Susan Rothmann, Denny Sakkas, Andrea Salonia, Maria Cristina Sánchez-Pozo, Rosanna Sapiro, Stefan Schlatt, Peter N Schlegel, Hans-Christian Schuppe, Rupin Shah, Niels E Skakkebæk, Katja Teerds, Igor Toskin, Herman Tournaye, Paul J Turek, Gerhard van der Horst, Monica Vazquez-Levin, Christina Wang, Alex Wetzels, Theodosia Zeginiadou, Armand Zini

Publikováno v: HUMAN REPRODUCTION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Human Reproduction, 37, 2497-2502
Human Reproduction
Human Reproduction, 2022, 37 (11), pp.2497-2502. ⟨10.1093/humrep/deac189⟩
Björndahl, L, Barratt, C L R, Mortimer, D, Agarwal, A, Aitken, R J, Alvarez, J G, Aneck-Hahn, N, Arver, S, Baldi, E, Bassas, L, Boitrelle, F, Bornman, R, Carrell, D T, Castilla, J A, Cerezo Parra, G, Check, J H, Cuasnicu, P S, Darney, S P, de Jager, C, De Jonge, C J, Drevet, J R, Drobnis, E Z, Du Plessis, S S, Eisenberg, M L, Esteves, S C, Evgeni, E A, Ferlin, A, Garrido, N, Giwercman, A, Goovaerts, I G F, Haugen, T B, Henkel, R, Henningsohn, L, Hofmann, M C, Hotaling, J M, Jedrzejczak, P, Jouannet, P, Jørgensen, N, Kirkman Brown, J C, Krausz, C, Kurpisz, M, Kvist, U, Lamb, D J, Levine, H, Loveland, K L, McLachlan, R I, Mahran, A, Maree, L, Martins da Silva, S, Mbizvo, M T, Meinhardt, A, Menkveld, R, Mortimer, S T, Moskovtsev, S, Muller, C H, Munuce, M J, Muratori, M, Niederberger, C, O'Flaherty, C, Oliva, R, Ombelet, W, Pacey, A A, Palladino, M A, Ramasamy, R, Ramos, L, Rives, N, Roldan, E R, Rothmann, S, Sakkas, D, Salonia, A, Sánchez-Pozo, M C, Sapiro, R, Schlatt, S, Schlegel, P N, Schuppe, H C, Shah, R, Skakkebæk, N E, Teerds, K, Toskin, I, Tournaye, H, Turek, P J, van der Horst, G, Vazquez-Levin, M, Wang, C, Wetzels, A, Zeginiadou, T & Zini, A 2022, ' Standards in semen examination : publishing reproducible and reliable data based on high-quality methodology ', Human Reproduction, vol. 37, no. 11, pp. 2497-2502 . https://doi.org/10.1093/humrep/deac189
Human reproduction (Oxford, England) 37 (2022) 11
Human reproduction
Human reproduction (Oxford, England), 37(11), 2497-2502
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

Biomedical science is rapidly developing in terms of more transparency, openness and reproducibility of scientific publications. This is even more important for all studies that are based on results from basic semen examination. Recently two concorda

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7218b3fb5ad10d580776ec380f57e6bc
https://doi.org/10.1093/humrep/deac189