Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kate L Fox"'
Autor:
Kate L Fox, John M Atack, Yogitha N Srikhanta, Anja Eckert, Laura A Novotny, Lauren O Bakaletz, Michael P Jennings
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90505 (2014)
Surface structures in Haemophilus influenzae are subject to rapid ON/OFF switching of expression, a process termed phase variation. We analyse tetranucleotide repeats controlling phase variation in lipo-oligosaccharide (LOS) genes of H. influenzae in
Externí odkaz:
https://doaj.org/article/6ad9f53aef594544843ef46748d417f7
Autor:
Benjamin L Schulz, Freda E C Jen, Peter M Power, Christopher E Jones, Kate L Fox, Shan C Ku, Joanne T Blanchfield, Michael P Jennings
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62768 (2013)
O-glycosylation of proteins in Neisseria meningitidis is catalyzed by PglL, which belongs to a protein family including WaaL O-antigen ligases. We developed two hidden Markov models that identify 31 novel candidate PglL homologs in diverse bacterial
Externí odkaz:
https://doaj.org/article/c5644d8ac81c4a25917daf0aa55e2761
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32337 (2012)
Phase variable restriction-modification (R-M) systems have been identified in a range of pathogenic bacteria. In some it has been demonstrated that the random switching of the mod (DNA methyltransferase) gene mediates the coordinated expression of mu
Externí odkaz:
https://doaj.org/article/8c416ba3b1084bd0a81bce95f6c12b96
Autor:
Yogitha N Srikhanta, Stefanie J Dowideit, Jennifer L Edwards, Megan L Falsetta, Hsing-Ju Wu, Odile B Harrison, Kate L Fox, Kate L Seib, Tina L Maguire, Andrew H-J Wang, Martin C Maiden, Sean M Grimmond, Michael A Apicella, Michael P Jennings
Publikováno v:
PLoS Pathogens, Vol 5, Iss 4, p e1000400 (2009)
Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to phase-variable expression (high-frequency reversible ON/OFF switching of gene expression). In Haemophilus influenzae, the random switching of the mod
Externí odkaz:
https://doaj.org/article/08072cebc5074ae19882428ccdcc5b0b
Autor:
Hannah K. Smith, Kevin Lee Nelson, Arnold L. Smith, Timothy M. VanWagoner, Terrence L. Stull, Kate L. Fox, Michael P. Jennings, John M. Atack
Publikováno v:
Microbial Pathogenesis. 92:60-67
Non-typeable Haemophilus influenzae (NTHi) is a human restricted commensal and pathogen that elicits inflammation by adhering to and invading airway epithelia cells: transcytosis across these cells can result in systemic infection. NTHi strain R2866
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d61179bd1b82a4a71ef69a1dcebbcc
https://doi.org/10.1016/j.micpath.2015.12.006
https://doi.org/10.1016/j.micpath.2015.12.006
Publikováno v:
Nature Reviews Microbiology. 8:196-206
In several host-adapted pathogens, phase variation has been found to occur in genes that encode methyltransferases associated with type III restriction-modification systems. It was recently shown that in the human pathogens Haemophilus influenzae, Ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338f35084e4699daeff4ec98922db68e
https://doi.org/10.1038/nrmicro2283
https://doi.org/10.1038/nrmicro2283
Publikováno v:
Molecular Microbiology. 65:1375-1379
Phase variation, the high-frequency on/off switching of gene expression, is a common feature of host-adapted bacterial pathogens. Restriction-modification (R-M) systems, which are ubiquitous among bacteria, are classically assigned the role of cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfdbe8a5d9d8460a11787536e000b9d
https://doi.org/10.1111/j.1365-2958.2007.05873.x
https://doi.org/10.1111/j.1365-2958.2007.05873.x
Autor:
Arnold L. Smith, Kate L. Fox, Alice L. Erwin, Yogitha N. Srikhanta, Stefanie J. Dowideit, Michael P. Jennings
Publikováno v:
Nucleic Acids Research
Phase variably expressed (randomly switching) methyltransferases associated with type III restriction-modification (R-M) systems have been identified in a variety of pathogenic bacteria. We have previously shown that a phase variable methyltransferas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea3ee3479947b7c1420206428b04ff8
https://doi.org/10.1093/nar/gkm571
https://doi.org/10.1093/nar/gkm571
Autor:
Jianjun Li, Michel Gilbert, Andrew D. Cox, Derek W. Hood, Kate L. Fox, Katherine Makepeace, Warren W. Wakarchuk, James C. Richards, E. Richard Moxon
Publikováno v:
Journal of Biological Chemistry. 281:40024-40032
The lipopolysaccharide (LPS) of non-typeable Haemophilus influenzae (NTHi) can be substituted at various positions by N-acetylneuraminic acid (Neu5Ac). LPS sialylation plays an important role in pathogenesis. The only LPS sialyltransferase characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47c7ea69ec6a79ea258a9de63e7f385f
https://doi.org/10.1074/jbc.m602314200
https://doi.org/10.1074/jbc.m602314200
Autor:
Kate L. Fox, Jayde A. Gawthorne, Ulla-Maja Bailey, Michael P. Jennings, Margaret R. Davis, Benjamin L. Schulz, Ranjitha Naidu, Linette W. Wong, Nikki Y. Tan
Publikováno v:
Biochemical and biophysical research communications. 445(3)
The HMWABC system of non-typeable Haemophilus influenzae (NTHi) encodes the HMWA adhesin glycoprotein, which is glycosylated by the HMWC glycosyltransferase. HMWC is a cytoplasmic N-glycosyltransferase, homologues of which are widespread in the Paste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcc2b0427b87d2154dd44c043d0e3bf
https://pubmed.ncbi.nlm.nih.gov/24565833
https://pubmed.ncbi.nlm.nih.gov/24565833