Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Kate J Heesom"'
Autor:
Christopher W Course, Philip A Lewis, Sarah J Kotecha, Michael Cousins, Kylie Hart, W John Watkins, Kate J Heesom, Sailesh Kotecha
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Introduction Although different phenotypes of lung disease after preterm birth have recently been described, the underlying mechanisms associated with each phenotype are poorly understood. We, therefore, compared the urinary proteome for dif
Externí odkaz:
https://doaj.org/article/c727780017884c948d7f07b4ccbc2cff
Autor:
Kirsty J McMillan, Paul J Banks, Francesca LN Hellel, Ruth E Carmichael, Thomas Clairfeuille, Ashley J Evans, Kate J Heesom, Philip Lewis, Brett M Collins, Zafar I Bashir, Jeremy M Henley, Kevin A Wilkinson, Peter J Cullen
Publikováno v:
eLife, Vol 10 (2021)
The endosome-associated cargo adaptor sorting nexin-27 (SNX27) is linked to various neuropathologies through sorting of integral proteins to the synaptic surface, most notably AMPA receptors. To provide a broader view of SNX27-associated pathologies,
Externí odkaz:
https://doaj.org/article/37f2888d4612454586ef6c3bee532043
Autor:
Alexander Greenhough, Clare Bagley, Kate J Heesom, David B Gurevich, David Gay, Mark Bond, Tracey J Collard, Chris Paraskeva, Paul Martin, Owen J Sansom, Karim Malik, Ann C Williams
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 11, Pp 1-13 (2018)
Abstract Hypoxia is a hallmark of solid tumours and a key physiological feature distinguishing cancer from normal tissue. However, a major challenge remains in identifying tractable molecular targets that hypoxic cancer cells depend on for survival.
Externí odkaz:
https://doaj.org/article/46c54f6455b9460fbdfd09461e4f6747
Autor:
Joseph Hawksworth, Timothy J Satchwell, Marjolein Meinders, Deborah E Daniels, Fiona Regan, Nicole M Thornton, Marieangela C Wilson, Johannes GG Dobbe, Geert J Streekstra, Kongtana Trakarnsanga, Kate J Heesom, David J Anstee, Jan Frayne, Ashley M Toye
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 6, Pp 1-11 (2018)
Abstract Regular blood transfusion is the cornerstone of care for patients with red blood cell (RBC) disorders such as thalassaemia or sickle‐cell disease. With repeated transfusion, alloimmunisation often occurs due to incompatibility at the level
Externí odkaz:
https://doaj.org/article/9af938bdb64040d3b9bf6a27b7e9cbb8
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function
Publikováno v:
eLife, Vol 7 (2018)
The dynein-2 microtubule motor is the retrograde motor for intraflagellar transport. Mutations in dynein-2 components cause skeletal ciliopathies, notably Jeune syndrome. Dynein-2 contains a heterodimer of two non-identical intermediate chains, WDR34
Externí odkaz:
https://doaj.org/article/04621b4cb39c4214a4e936166d804e58
Autor:
Kongtana Trakarnsanga, Marieangela C Wilson, Rebecca E Griffiths, Ashley M Toye, Lee Carpenter, Kate J Heesom, Steve F Parsons, David J Anstee, Jan Frayne
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e100874 (2014)
Induced pluripotent stem cells (iPSC) are an attractive progenitor source for the generation of in vitro blood products. However, before iPSC-derived erythroid cells can be considered for therapeutic use their similarity to adult erythroid cells must
Externí odkaz:
https://doaj.org/article/a5c97a43397a4584ad42b90d3800431e
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e93305 (2014)
Disease caused by dengue virus is a global health concern with up to 390 million individuals infected annually worldwide. There are no vaccines or antiviral compounds available to either prevent or treat dengue disease which may be fatal. To increase
Externí odkaz:
https://doaj.org/article/96d52a10841d46e397f7a44441e5937a
Autor:
Amanda J Bell, Timothy J Satchwell, Kate J Heesom, Bethan R Hawley, Sabine Kupzig, Matthew Hazell, Rosey Mushens, Andrew Herman, Ashley M Toye
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60300 (2013)
Enucleation is the step in erythroid terminal differentiation when the nucleus is expelled from developing erythroblasts creating reticulocytes and free nuclei surrounded by plasma membrane. We have studied protein sorting during human erythroblast e
Externí odkaz:
https://doaj.org/article/aefb405fd1454b84992a9a2f728bbc5f
Autor:
Stéphanie Pellegrin, Kate J Heesom, Timothy J Satchwell, Bethan R Hawley, Geoff Daniels, Emile van den Akker, Ashley M Toye
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38356 (2012)
The availability of Erythropoietin (Epo) is essential for the survival of erythroid progenitors. Here we study the effects of Epo removal on primary human erythroblasts grown from peripheral blood CD34(+) cells. The erythroblasts died rapidly from ap
Externí odkaz:
https://doaj.org/article/77a909261a354c24aa6901eca4bf7ee1
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8513 (2009)
Three functional c-ras genes, known as c-H-ras, c-K-ras, and c-N-ras, have been largely studied in mammalian cells with important insights into normal and tumorigenic cellular signal transduction events. Two K-Ras mRNAs are obtained from the same pre
Externí odkaz:
https://doaj.org/article/94ce9d3ea0ed4d039c31b0f6c9458ce9