Zobrazeno 1 - 10
of 244
pro vyhledávání: '"Kate J Heesom"'
Autor:
Abigail C. Lay, Van Du T. Tran, Viji Nair, Virginie Betin, Jennifer A. Hurcombe, Alexandra F. Barrington, Robert JP Pope, Frédéric Burdet, Florence Mehl, Dmytro Kryvokhyzha, Abrar Ahmad, Matthew C. Sinton, Philip Lewis, Marieangela C. Wilson, Rajasree Menon, Edgar Otto, Kate J. Heesom, Mark Ibberson, Helen C. Looker, Robert G. Nelson, Wenjun Ju, Matthias Kretzler, Simon C. Satchell, Maria F. Gomez, Richard J. M. Coward, BEAt-DKD consortium
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Diabetic kidney disease (DKD) is the leading cause of end stage kidney failure worldwide, of which cellular insulin resistance is a major driver. Here, we study key human kidney cell types implicated in DKD (podocytes, glomerular endothelial
Externí odkaz:
https://doaj.org/article/b623e2a205714bcbbfbb61ff109ce900
Autor:
Christopher W. Course, Philip A. Lewis, Sarah J. Kotecha, Michael Cousins, Kylie Hart, Kate J. Heesom, W. John Watkins, Sailesh Kotecha
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Prematurity-associated lung disease (PLD) is a long-term consequence of preterm-birth. Since the underlying mechanisms of PLD remain poorly characterised, we compared the urinary metabolome between recently described spirometry phenotypes of
Externí odkaz:
https://doaj.org/article/2936bb02596542c58c3146b9e970cdcc
Autor:
Christopher W. Course, Philip A. Lewis, Sarah J. Kotecha, Michael Cousins, Kylie Hart, Kate J. Heesom, W. John Watkins, Sailesh Kotecha
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Preterm-born children are at risk of long-term pulmonary deficits, including those who developed bronchopulmonary dysplasia (BPD) in infancy, however the underlying mechanisms remain poorly understood. We characterised the exhaled breath con
Externí odkaz:
https://doaj.org/article/760399c5e4e34e9ab59518603979260d
Autor:
Christopher W Course, Philip A Lewis, Sarah J Kotecha, Michael Cousins, Kylie Hart, W John Watkins, Kate J Heesom, Sailesh Kotecha
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Introduction Although different phenotypes of lung disease after preterm birth have recently been described, the underlying mechanisms associated with each phenotype are poorly understood. We, therefore, compared the urinary proteome for dif
Externí odkaz:
https://doaj.org/article/c727780017884c948d7f07b4ccbc2cff
Autor:
James L. Daly, Chris M. Danson, Philip A. Lewis, Lu Zhao, Sara Riccardo, Lucio Di Filippo, Davide Cacchiarelli, Daehoon Lee, Stephen J. Cross, Kate J. Heesom, Wen-Cheng Xiong, Andrea Ballabio, James R. Edgar, Peter J. Cullen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Retromer controls cellular homeostasis through regulating integral membrane protein sorting and transport and by controlling maturation of the endo-lysosomal network. Retromer dysfunction, which is linked to neurodegenerative disorders inclu
Externí odkaz:
https://doaj.org/article/25c4f4af8ff64ff395880ff48cfb4aa6
Autor:
Christopher W. Course, Philip A. Lewis, Sarah J. Kotecha, Michael Cousins, Kylie Hart, W. John Watkins, Kate J. Heesom, Sailesh Kotecha
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Despite evidence demonstrating persistent lung function deficits in preterm-born children, especially in those who had bronchopulmonary dysplasia (BPD) in infancy, the underlying biological mechanisms explaining these lung function deficits
Externí odkaz:
https://doaj.org/article/65bcf8964d564e0382bba338e7c561fd
Autor:
Chartsiam Tipgomut, Archrob Khuhapinant, Marieangela C. Wilson, Saiphon Poldee, Kate J. Heesom, Chanatip Metheetrairut, Orapan Sripichai, Chalermchai Mitrpant, Jan Frayne, Kongtana Trakarnsanga
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Polycythaemia vera (PV) is a haematological disorder caused by an overproduction of erythroid cells. To date, the molecular mechanisms involved in the disease pathogenesis are still ambiguous. This study aims to identify aberrantly expressed
Externí odkaz:
https://doaj.org/article/5b15d64123864b8b8feb2015fea7d143
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Perico et al. use co-expression analysis and a FRET-FLIM approach to show that the Arabidopsis MyoB myosin receptor, MRF7, triggers the relocation of Myosin XI-K to the Golgi. As such, this study provides evidence for plant myosin recruitment and con
Externí odkaz:
https://doaj.org/article/6d0322a6c6e8479fb81da4d1a2b0f731
Autor:
Philip Hinchliffe, Catherine L. Tooke, Christopher R. Bethel, Benlian Wang, Christopher Arthur, Kate J. Heesom, Stuart Shapiro, Daniela M. Schlatzer, Krisztina M. Papp-Wallace, Robert A. Bonomo, James Spencer
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT β-Lactamases hydrolyze β-lactam antibiotics and are major determinants of antibiotic resistance in Gram-negative pathogens. Enmetazobactam (formerly AAI101) and tazobactam are penicillanic acid sulfone (PAS) β-lactamase inhibitors that di
Externí odkaz:
https://doaj.org/article/b7b931b90cef4f15b5875e2a595d88ff
Autor:
Abdulaziz Almuqrin, Andrew D. Davidson, Maia Kavanagh Williamson, Philip A. Lewis, Kate J. Heesom, Susan Morris, Sarah C. Gilbert, David A. Matthews
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background ChAdOx1 nCoV-19 is a recombinant adenovirus vaccine against SARS-CoV-2 that has passed phase III clinical trials and is now in use across the globe. Although replication-defective in normal cells, 28 kbp of adenovirus genes is del
Externí odkaz:
https://doaj.org/article/e1230c43536748bfa473cef2663111c6