MulTI-domain self-management in older People wiTh OstEoarthritis and multi-morbidities: protocol for the TIPTOE randomised controlled trial

Autor: Rachel Deere, Philip Pallmann, Victoria Shepherd, Lucy Brookes-Howell, Andrew Carson-Stevens, Ffion Davies, Emma Dunphy, Preeti Gupta, Mary Hickson, Val Hill, Kate Ingarfield, Nicola Ivins, Fiona Jones, Robert Letchford, Rachel Lowe, Sarah Nash, Paula Otter, Hayley Prout, Elizabeth Randell, Bernadette Sewell, Debs Smith, Robert Trubey, Tom Wainwright, Monica Busse, Kate Button

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-15 (2024)

Abstract Background Four out of five people living with osteoarthritis (OA) also suffer with at least one other long-term health condition. The complex interaction between OA and multiple long-term conditions (MLTCs) can result in difficulties with s

Externí odkaz: https://doaj.org/article/d09549f1940f4c5289f1665426cb2f90

Inequality in the Survival of Patients With Head and Neck Cancer in Scotland

Autor: Kate Ingarfield, Alex Douglas McMahon, Catriona M. Douglas, Shirley-Anne Savage, Kenneth MacKenzie, David I. Conway

Publikováno v: Frontiers in Oncology, Vol 8 (2019)

Background: Socioeconomic inequalities impact on the survival of head and neck cancer (HNC) patients, but there is limited understanding of the explanations of the inequality, particularly in long-term survival.Methods: Patients were recruited from t

Externí odkaz: https://doaj.org/article/76bb86d2494f4afe8399ee78c583e5fa

Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial

Autor: Sacha J Howell, Angela Casbard, Margherita Carucci, Kate Ingarfield, Rachel Butler, Sian Morgan, Magdalena Meissner, Catherine Bale, Pavel Bezecny, Sarah Moon, Chris Twelves, Ramachandran Venkitaraman, Simon Waters, Elza C de Bruin, Gaia Schiavon, Andrew Foxley, Robert H Jones

Publikováno v: Howell, S J, Casbard, A, Carucci, M, Ingarfield, K, Butler, R, Morgan, S, Meissner, M, Bale, C, Bezecny, P, Moon, S, Twelves, C, Venkitaraman, R, Waters, S, de Bruin, E C, Schiavon, G, Foxley, A & Jones, R H 2022, ' Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION) : overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial ', The Lancet. Oncology, vol. 23, no. 7, pp. 851-864 . https://doi.org/10.1016/S1470-2045(22)00284-4

BACKGROUND: Capivasertib, an AKT inhibitor, added to fulvestrant, was previously reported to improve progression-free survival in women with aromatase inhibitor-resistant oestrogen receptor (ER)-positive, HER2-negative advanced breast cancer. The ben

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8b7c1cc7c7d91a6ed98ec5f578778f
https://doi.org/10.1016/s1470-2045(22)00284-4

Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer

Autor: Ryan Langdon, Ingle S, Andy R Ness, Michael Pawlita, Rebecca C Richmond, Matthew Suderman, Daniel L. McCartney, Caroline L Relton, Davey Smith G, Tim Waterboer, Kate Ingarfield, R Beynon, Margaret T May, Riccardo E. Marioni, Richard M. Martin

Publikováno v: Beynon, R A, Ingle, S M, Langdon, R J, May, M T, Martin, R M, Ness, A R, Suderman, M J, Ingarfield, K, Marioni, R E, McCartney, D L, Waterboer, T, Pawlita, M, Relton, C L, Davey Smith, G & Richmond, R 2022, ' Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer ', Clinical Epigenetics, vol. 14, no. 1, 1 . https://doi.org/10.1186/s13148-021-01220-4
Clinical Epigenetics

Background Epigenetic clocks are biomarkers of ageing derived from DNA methylation levels at a subset of CpG sites. The difference between age predicted by these clocks and chronological age, termed “epigenetic age acceleration”, has been shown t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6629ee2880040e344364d4c3aeca4854
https://research-information.bris.ac.uk/ws/files/312233741/s13148_021_01220_4.pdf

Determinants of long‐term survival in a population‐based cohort study of patients with head and neck cancer from Scotland

Autor: Shirley-Anne Savage, Kenneth MacKenzie, Alex D. McMahon, David I. Conway, Kate Ingarfield, Catriona M. Douglas

Publikováno v: Head & Neck. 41:1908-1917

Background: We investigated long‐term survival from head and neck cancer (HNC) using different survival approaches. Methods: Patients were followed‐up from the Scottish Audit of Head and Neck Cancer. Overall survival and disease‐specific surviv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5ebd2cf2e8a9feada1bfce2306e6f7
https://doi.org/10.1002/hed.25630