Výsledky vyhledávání - "Kate H. Gowers"

Abstract 218: Somatic mutations in single-cell derived alveolar organoids

Autor: Moritz Jakob Przybilla, Amany Ammar, Ryan Chuen Khaw, Andrew R. Lawson, Pantelis Nicola, Kate Davies, Zoe Frazer, Kate H. Gowers, Timothy M. Butler, Sarah E. Clarke, Inigo Martincorena, Sam M. Janes, Peter J. Campbell

Publikováno v: Cancer Research. 83:218-218

The diversity in somatic variation across human tissues outshining human cancers has only recently been started to be appreciated. In particular, healthy individuals carry large numbers of cells and clonal expansions with mutations in driver genes co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eae34e2ec1965198c269b3de6a7645e5
https://doi.org/10.1158/1538-7445.am2023-218

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Abstract 3096: Multi-region patient-derived xenograft models from non-small cell lung cancer patients enrolled in lung TRACERx

Autor: Robert E. Hynds, David R. Pearce, Ayse U. Akarca, Sophia Ward, Ariana Huebner, Oriol Pich, Gareth A. Wilson, Kate H. Gowers, Rebecca Towns, Assma Ben Aissa, Selvaraju Veeriah, Sergio A. Quezada, Mariam Jamal-Hanjani, Sam M. Janes, Nicholas McGranahan, David A. Moore, Teresa Marafioti, Charles Swanton

Publikováno v: Cancer Research. 82:3096-3096

Patient-derived xenograft (PDX) models have become important models in cancer biology. They are thought to mimic tumor biology more closely than traditional cell lines as a consequence of their in vivo heterocellularity and cell-matrix interactions,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0597b494a6be17fe6815a702580fd155
https://doi.org/10.1158/1538-7445.am2022-3096

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Abstract 3158: Defining the mechanisms that lead to mutational heterogeneity in the normal respiratory epithelium

Autor: Kate H. Gowers, Sarah E. Clarke, Ayu Hutami Syaraf, Kenichi Yoshida, Moritz J. Przybilla, Hugh Selway, Adam Pennycuick, Peter J. Campbell, Sam M. Janes

Publikováno v: Cancer Research. 82:3158-3158

It is well established that tobacco smoking causes lung cancer and this is thought to be the result of a progressive accumulation of genomic mutations induced by tobacco smoke exposure; however, until recently a detailed understanding of the effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45e6ec2c5e4c0c36b40ef26e39e53f13
https://doi.org/10.1158/1538-7445.am2022-3158

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