Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kate F. Wickson"'
Autor:
Liz Flavell, Jakub Luptak, David J. Hargreaves, Steven L. Kazmirski, Tina Howard, Kate F. Wickson, Ning Gao, David I Fisher, Michal Bista, Philip B. Rawlins
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
Mcl-1 is an important cancer target for drug therapy, through which normal apoptosis may be restored by inhibiting its protective function. An scFv and a Fab have been used to generate an apo Mcl-1 crystal system that is amenable to iterative structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f1ff2f5c281e68c59c2e4b03cee5ac
http://europepmc.org/articles/PMC6834078
http://europepmc.org/articles/PMC6834078
Autor:
David Hargeaves, Elizabeth England, Robert M. Woods, Michael Fung, Caroline Colley, Paul Warrener, Liz Flavell, Sudharsan Sridharan, Judit E. Debreczeni, Jessica Bonnell, Claire Dobson, Jingying Zha, Bryan M. Edwards, Ling-Ling An, Laura Eghobamien, Ulf Sivars, Joanne Arnold, Jonathan Renshaw, Bojana Popovic, Kate F. Wickson, Tristan J. Vaughan, Trevor Wilkinson
Publikováno v:
mAbs
'mAbs ', vol: 10, pages: 104-117 (2018)
'mAbs ', vol: 10, pages: 104-117 (2018)
C5a is a potent anaphylatoxin that modulates inflammation through the C5aR1 and C5aR2 receptors. The molecular interactions between C5a–C5aR1 receptor are well defined, whereas C5a–C5aR2 receptor interactions are poorly understood. Here, we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3b26c96696e2eb620d74383a366038
http://europepmc.org/articles/PMC5800367
http://europepmc.org/articles/PMC5800367
Autor:
Martin J. Packer, David J. Hargreaves, Xiaolan Zheng, Nancy Su, Haiye Lan, Carl Beigie, Christoph E. Dumelin, Matthew A. Belmonte, Chengyan Wu, Hao Ma, Dawn M. Troast, Haidong Shen, Anthony D. Keefe, Ying Zhang, Kate F. Wickson, Philip B. Rawlins, Yunxia Li, John W. Cuozzo, Steven L. Kazmirski, Michelle Lamb, Eric A. Sigel, Paolo A. Centrella, Matthew A. Clark, Camil Joubran, Haiyun Wang, Scott Mlynarski, Shenggen Cao, Stephanie M. Bates, Holly H. Soutter, Qiuying Zhao, Daniel W. Robbins, Jeffrey W. Johannes, Sevan Habeshian, John Breen, Andrew D. Ferguson, Alexander Hird
Publikováno v:
ACS Medicinal Chemistry Letters. 8:239-244
Mcl-1 is a pro-apoptotic BH3 protein family member similar to Bcl-2 and Bcl-xL. Overexpression of Mcl-1 is often seen in various tumors and allows cancer cells to evade apoptosis. Here we report the discovery and optimization of a series of non-natur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63c21134d85b4a073399258fa542278c
https://doi.org/10.1021/acsmedchemlett.6b00464
https://doi.org/10.1021/acsmedchemlett.6b00464
Autor:
Haiye Lan, Sevan Habeshian, Yunxia Li, Ying Zhang, Matthew A. Belmonte, Philip B. Rawlins, Chengyan Wu, Daniel W. Robbins, John Breen, Christoph E. Dumelin, Holly H. Soutter, Martin J. Packer, Carl Beigie, Nancy Su, David J. Hargreaves, Xiaolan Zheng, Scott Mlynarski, Stephanie M. Bates, Steven L. Kazmirski, Michelle Lamb, Matthew A. Clark, Dawn M. Troast, Shenggen Cao, Haiyun Wang, Qiuying Zhao, Jeffrey W. Johannes, John W. Cuozzo, Kate F. Wickson, Eric A. Sigel, Paolo A. Centrella, Camil Joubran, Hao Ma, Haidong Shen, Anthony D. Keefe, Alexander Hird, Andrew D. Ferguson
Publikováno v:
ACS medicinal chemistry letters. 8(11)
Mcl-1 is a pro-apoptotic BH3 protein family member similar to Bcl-2 and Bcl-xL. Overexpression of Mcl-1 is often seen in various tumors and allows cancer cells to evade apoptosis. Here we report the discovery and optimization of a series of non-natur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fd323d411d2e4e54704e3719e8e07c
https://pubmed.ncbi.nlm.nih.gov/28197319
https://pubmed.ncbi.nlm.nih.gov/28197319
Autor:
H. Gingell, Steven Powell, Allan Dishington, Andrew L Roberts, Frederick W. Goldberg, Nicola J. Roberts, Richard A. Norman, Richard A. Ward, Kate F. Wickson, Judit E. Debreczeni
Publikováno v:
Journal of Medicinal Chemistry. 52:7901-7905
A novel class of 4-pyridinoxy-2-anilinopyridine-based TGF-beta type I receptor (also known as activin-like kinase 5 or ALK5) inhibitors is reported. The binding mode of this scaffold was successfully predicted by analyzing possible docked binding mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0cb7e6426129455b599364fb5ecdbc
https://doi.org/10.1021/jm900807w
https://doi.org/10.1021/jm900807w
Autor:
Stuart L. Warriner, Darren C. Tomlinson, Alexander L. Breeze, Jonathan Stott, Adam Nelson, Hannah F. Kyle, Christian Tiede, Andrew J. Wilson, Thomas A. Edwards, George M. Burslem, Kate F. Wickson
Publikováno v:
Molecular bioSystems. 11(10)
The HIF-1α/p300 protein–protein interaction plays a key role in tumor metabolism and thus represents a high value target for anticancer drug-development. Although several studies have identified inhibitor candidates using rationale design, more de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194791bc3a6395ab847a922962010185
https://pubmed.ncbi.nlm.nih.gov/26135796
https://pubmed.ncbi.nlm.nih.gov/26135796
Autor:
Frederick W. Goldberg, Richard A. Ward, Steven J. Powell, Judit É. Debreczeni, Richard A. Norman, Nicola J. Roberts, Allan P. Dishington, Helen J. Gingell, Kate F. Wickson, Andrew L. Roberts
Publikováno v:
Journal of Medicinal Chemistry; Dec2009, Vol. 52 Issue 23, p7901-7905, 5p