Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kate E. Galloway"'
Publikováno v:
Trends in Biotechnology. 40:210-225
Within mammalian systems, there exists enormous opportunity to use synthetic gene circuits to enhance phenotype-based drug discovery, to map the molecular origins of disease, and to validate therapeutics in complex cellular systems. While drug discov
Autor:
Alan Cabrera, Hailey I. Edelstein, Fokion Glykofrydis, Kasey S. Love, Sebastian Palacios, Josh Tycko, Meng Zhang, Sarah Lensch, Cara E. Shields, Mark Livingston, Ron Weiss, Huimin Zhao, Karmella A. Haynes, Leonardo Morsut, Yvonne Y. Chen, Ahmad S. Khalil, Wilson W. Wong, James J. Collins, Susan J. Rosser, Karen Polizzi, Michael B. Elowitz, Martin Fussenegger, Isaac B. Hilton, Joshua N. Leonard, Lacramioara Bintu, Kate E. Galloway, Tara L. Deans
Publikováno v:
Cabrera, A, Edelstein, H I, Glykofrydis, F, Love, K S, Palacios, S, Tycko, J, Zhang, M, Lensch, S, Shields, C E, Livingston, M, Weiss, R, Zhao, H, Haynes, K A, Morsut, L, Chen, Y Y, Khalil, A S, Wong, W W, Collins, J J, Rosser, S J, Polizzi, K, Elowitz, M B, Fussenegger, M, Hilton, I B, Leonard, J N, Bintu, L, Galloway, K E & Deans, T L 2022, ' The sound of silence : Transgene silencing in mammalian cell engineering ', Cell Systems, vol. 13, no. 12, pp. 950-973 . https://doi.org/10.1016/j.cels.2022.11.005
To elucidate principles operating in native biological systems and to develop novel biotechnologies, synthetic biology aims to build and integrate synthetic gene circuits within native transcriptional networks. The utility of synthetic gene circuits
Publikováno v:
Cell reports. 41(3)
Transcription induces a wave of DNA supercoiling, altering the binding affinity of RNA polymerases and reshaping the biochemical landscape of gene regulation. As supercoiling rapidly diffuses, transcription dynamically reshapes the regulation of prox
Autor:
Christopher Johnstone, Kate E Galloway
Transcription induces a wave of DNA supercoiling, altering the binding affinity of RNA polymerases and reshaping the biochemical landscape of gene regulation. As supercoiling rapidly diffuses, transcription dynamically reshapes the regulation of prox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6420df07ba81f46da84b0775d8fd5197
https://doi.org/10.1101/2022.04.20.488937
https://doi.org/10.1101/2022.04.20.488937
Publikováno v:
Current Opinion in Systems Biology. 24:18-31
Cellular reprogramming drives cells from one stable identity to a new cell fate. By generating a diversity of previously inaccessible cell types from diverse genetic backgrounds, cellular reprogramming is rapidly transforming how we study disease. Ho
Autor:
Kate E. Galloway, Nathan B. Wang
Publikováno v:
Cell Syst
Biological information can be encoded within the dynamics of signaling components, which has been implicated in a broad range of physiological processes including stress response, oncogenesis, and stem cell differentiation. To study the complexity of
Autor:
Cole Trapnell, Uri Alon, Rinat Arbel-Goren, Jennifer Cable, Sabrina L. Spencer, Aaron M. Streets, Bo Wang, Jean Fan, Naomi Habib, Shalev Itzkovitz, Roser Vento-Tormo, Hernan G. Garcia, Andrew B. Stergachis, Merrit Romeike, Prisca Liberali, Arjun Raj, Noah F. Greenwald, Geethika Arekatla, Martin Guilliams, Clarice Kit Yee Hong, Allon M. Klein, Alex K. Shalek, Stephen R. Quake, Long Cai, Michael Ratz, Sarah J. Pfau, Jan Philipp Junker, Leeat Keren, Itai Yanai, Homaira Hamidzada, Michael S. Balzer, Silvia D.M. Santos, John I. Murray, Michael B. Elowitz, Jessica L. Whited, Ana Domingos, Steffen Rulands, Nan Zhang, Regan Hamel, Samantha A. Morris, Federico Gaiti, Kate E. Galloway
Publikováno v:
Annals of the New York Academy of SciencesReferences. 1506(1)
Single cell biology has the potential to elucidate many critical biological processes and diseases, from development and regeneration to cancer. Single cell analyses are uncovering the molecular diversity of cells, revealing a clearer picture of the
Publikováno v:
Nature reviews. Molecular cell biology. 22(6)
Publikováno v:
Nature Reviews Molecular Cell Biology. 22:369-370
Development unfolds through a series of orchestrated spatial and temporal gene-expression patterns. Despite relying on the noisy process of transcription, expression patterns remain robust to myriad disturbances. To achieve the goal of building compl
Autor:
Nicholas Atwater, Hongcang Gu, Alexander Meissner, Kevin Eggan, Kendell Clement, Kate E. Galloway, Justin K. Ichida, Andreas Gnirke, Kimberly N. Babos, Kim A. Staats, Yingxiao Shi, Evangelos Kiskinis, Esther Y. Son, Brandi N. Davis-Dusenbery
Publikováno v:
Development
Advances in stem cell science allow the production of different cell types in vitro either through the recapitulation of developmental processes, often termed “directed differentiation,” or the forced expression of lineage-specific transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ab2007f5baa8d5e4b8b1c4c158ffef
https://hdl.handle.net/21.11116/0000-0003-4D51-C21.11116/0000-0003-4D52-B21.11116/0000-0003-4D4F-0
https://hdl.handle.net/21.11116/0000-0003-4D51-C21.11116/0000-0003-4D52-B21.11116/0000-0003-4D4F-0