Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kate Duffus"'
Autor:
Jing Yang, Amanda McGovern, Paul Martin, Kate Duffus, Xiangyu Ge, Peyman Zarrineh, Andrew P. Morris, Antony Adamson, Peter Fraser, Magnus Rattray, Stephen Eyre
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Although genome-wide association studies have identified genetic variation contributing to disease risk, assigning causal genes is challenging. Here, the authors generate ATAC-seq, Hi-C, Capture Hi-C and RNA-seq data in stimulated CD4+ T cells to ide
Externí odkaz:
https://doaj.org/article/cfb2cf5b4bb44d5cacaff7677eed292d
Autor:
Helen Ray-Jones, Kate Duffus, Amanda McGovern, Paul Martin, Chenfu Shi, Jenny Hankinson, Oliver Gough, Annie Yarwood, Andrew P. Morris, Antony Adamson, Christopher Taylor, James Ding, Vasanthi Priyadarshini Gaddi, Yao Fu, Patrick Gaffney, Gisela Orozco, Richard B. Warren, Steve Eyre
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largely a result of the fin
Externí odkaz:
https://doaj.org/article/fc874bf79d974ecf8ffc27cc8532e984
Autor:
Paul Martin, Amanda McGovern, Jonathan Massey, Stefan Schoenfelder, Kate Duffus, Annie Yarwood, Anne Barton, Jane Worthington, Peter Fraser, Stephen Eyre, Gisela Orozco
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166923 (2016)
BackgroundThe chromosomal region 6q23 has been found to be associated with multiple sclerosis (MS) predisposition through genome wide association studies (GWAS). There are four independent single nucleotide polymorphisms (SNPs) associated with MS in
Externí odkaz:
https://doaj.org/article/8522a4146c414caba49e01a735871ae1
Autor:
Steve Eyre, Magnus Rattray, Peyman Zarrineh, Antony Adamson, Paul Martin, Jing Yang, Peter Fraser, Xiangyu Ge, Andrew P. Morris, Kate Duffus, Amanda McGovern
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Yang, J, Mcgovern, A, Martin, P, Duffus, K, Ge, X, Zarrineh, P, Morris, A, Adamson, A, Fraser, P, Rattray, M & Eyre, S 2020, ' Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis ', Nature Communications, vol. 11, 4402 . https://doi.org/10.1038/s41467-020-18180-7
Nature Communications
Yang, J, Mcgovern, A, Martin, P, Duffus, K, Ge, X, Zarrineh, P, Morris, A, Adamson, A, Fraser, P, Rattray, M & Eyre, S 2020, ' Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis ', Nature Communications, vol. 11, 4402 . https://doi.org/10.1038/s41467-020-18180-7
Nature Communications
Genome-wide association studies have identified genetic variation contributing to complex disease risk. However, assigning causal genes and mechanisms has been more challenging because disease-associated variants are often found in distal regulatory
Autor:
Richard B. Warren, Jenny Hankinson, Patrick M. Gaffney, Magnus Rattray, Oliver Gough, Stephen Eyre, Gisela Orozco, Kate Duffus, Annie Yarwood, Chenfu Shi, Yao Fu, James Ding, Amanda McGovern, Paul Martin, Helen Ray-Jones, Vasanthipriyadarshini Gaddi
Publikováno v:
Shi, C, Ray-Jones, H, Ding, J, Duffus, K, Fu, Y, Gaddi, V P, Gough, O, Hankinson, J, Martin, P, McGovern, A, Yarwood, A, Gaffney, P, Eyre, S, Rattray, M, Warren, R B & Orozco, G 2021, ' Chromatin Looping Links Target Genes with Genetic Risk Loci for Dermatological Traits ', The Journal of Investigative Dermatology, vol. 141, no. 8, pp. 1975-1984 . https://doi.org/10.1016/j.jid.2021.01.015
Chromatin looping between regulatory elements and gene promoters presents a potential mechanism whereby disease risk variants affect their target genes. In this study, we use H3K27ac HiChIP, a method for assaying the active chromatin interactome in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d10994e884e95df7c74f8f969732cb8
https://research.manchester.ac.uk/en/publications/91e6427b-0c9e-4dfa-8686-9d2cb38a339a
https://research.manchester.ac.uk/en/publications/91e6427b-0c9e-4dfa-8686-9d2cb38a339a
Autor:
Mark Caulfield, Solbritt Rantapää Dahlqvist, Eleftheria Zeggini, Michael Weedon, Paul Martin, Elaine Dennison, Patricia Munroe, Detelina Grozeva, John Isaacs, Stephen Eyre, Alex MacGregor, Kate Duffus, Andrew Hattersley, DOROTHEE DIOGO, Luis Rodriguez-Rodriguez, Steven Young-Min, Chris Wallace, Miguel Gonzalez-Gay, Tom Huizinga, Stephen Newhouse, Alexandra Zhernakova, Melanie Newport, Deborah Symmons, Lisa Jones, Michael O'Donovan, Wan-Fai Ng, Nadira Yusupovna Yuldasheva, Cyrus Cooper, Willem Ouwehand, Philip Conaghan, Gerome Breen, Lars Alfredsson, Karim Raza, Hana Lango Allen, Jane Worthington, Mark Iles, Ann Morgan, Professor David Dunger, Soumya Raychaudhuri, Panos Deloukas, Marwan Bukhari, Alastair Forbes, Allan Young, Lars Klareskog, Leonid Padyukov, Fraser Birrell, Charlie Lees, Anne Barton, Martin Tobin, Patrick Concannon, Jon Packham, Natalie Prescott, Javier Martin, Kimme Hyrich, Lude Franke, John Bowes, Ian Bruce, Chiea Chuen Khor, Stephen Rich, Miles Parkes, Sarah Hunt, Tim Bishop, Gosia Trynka, Richard Dobson, Anna Dominiczak, Cisca Wijmenga, Mark McCarthy, Cecilia Lindgren, Rene Toes, Alistair Hall
Publikováno v:
Nature Genetics, 44(12), 1336-1340. Nature Publishing Group
Nature Genetics, 44(12), 1336-1340
Nature genetics
Nature Genetics, 44(12), 1336-1340
Nature genetics
Using the Immunochip custom SNP array, which was designed for dense genotyping of 186 loci identified through genome-wide association studies (GWAS), we analyzed 11,475 individuals with rheumatoid arthritis (cases) of European ancestry and 15,870 con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65582d467a3a6efd2d9d56dc4e9b5ee
Autor:
Jenny Hankinson, Steve Eyre, Patrick M. Gaffney, Gisela Orozco, Oliver Gough, Amanda McGovern, James Ding, Andrew P. Morris, Kate Duffus, Helen Ray-Jones, Paul Martin, Yao Fu, Vasanthi Priyadarshini Gaddi, Chenfu Shi, Antony Adamson, Richard B. Warren, Christopher J. Taylor, Annie Yarwood
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
BMC Biology
Ray-Jones, H, Duffus, K, Mcgovern, A, Martin, P, Shi, C, Hankinson, J, Gough, O, Yarwood, A, Morris, A, Adamson, A, Taylor, C, Ding, J, Gaddi, V, Fu, Y, Gaffney, P, Orozco, G, Warren, R & Eyre, S 2020, ' Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31 ', BMC Biology, vol. 18, no. 1, 47 . https://doi.org/10.1186/s12915-020-00779-3
BMC Biology
Ray-Jones, H, Duffus, K, Mcgovern, A, Martin, P, Shi, C, Hankinson, J, Gough, O, Yarwood, A, Morris, A, Adamson, A, Taylor, C, Ding, J, Gaddi, V, Fu, Y, Gaffney, P, Orozco, G, Warren, R & Eyre, S 2020, ' Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31 ', BMC Biology, vol. 18, no. 1, 47 . https://doi.org/10.1186/s12915-020-00779-3
Background Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largely a result of the findings tha
Autor:
Gisela Orozco, Richard B. Warren, Jenny Hankinson, Helen Ray-Jones, Chenfu Shi, Magnus Rattray, Patrick M. Gaffney, Amanda McGovern, Yao Fu, Annie Yarwood, Paul Martin, Oliver Gough, Steve Eyre, Vasanthi Priyadarshini Gaddi, Kate Duffus, James Ding
In the last 15 years Genome wide association studies (GWAS) have uncovered the genetic factors that contribute to disease risk for many disorders, yet the biological significance of many of these associations remain unclear. This is because about 90%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::839bc0bab0d6ffe32d71648f412a25c6
https://doi.org/10.1101/2020.03.05.973271
https://doi.org/10.1101/2020.03.05.973271
Autor:
Antony Adamson, Vasanthi Priyadarshini Gaddi, Oliver Gough, Richard B. Warren, Jenny Hankinson, Andrew P. Morris, Chenfu Shi, Annie Yarwood, Kate Duffus, Christopher J. Taylor, Patrick M. Gaffney, Amanda McGovern, Yao Fu, James Ding, Steve Eyre, Paul Martin, Helen Ray-Jones, Gisela Orozco
Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. Here, we use a disease-focused Capture Hi-C experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309cadfd44c6a9d8f5463452a4de4731
https://doi.org/10.1101/822304
https://doi.org/10.1101/822304
Autor:
Sofia Vargas, Theoni Katopodi, Gisela Orozco, Chenfu Shi, Kate Duffus, Amanda McGovern, Annie Yarwood, Vasanthi Priyadarshini Gaddi, Marialbert Acosta-Herrera, Nadia Iqbal, Javier Ibáñez, James Ding, Enrique Raya, Paul Martin
Publikováno v:
Poster Presentations.
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of synovial joints. RA is a clinically heterogeneous disease and treatment response varies between individuals. The pathogenesis of RA is not completel