Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Kate Connor"'
Autor:
Kathryn H. Brown, Brianna N. Kerr, Mihaela Pettigrew, Kate Connor, Ian S. Miller, Liam Shiels, Colum Connolly, Conor McGarry, Annette T. Byrne, Karl T. Butterworth
Publikováno v:
Physics and Imaging in Radiation Oncology, Vol 31, Iss , Pp 100615- (2024)
Background and purpose: Radiomics analysis extracts quantitative data (features) from medical images. These features could potentially reflect biological characteristics and act as imaging biomarkers within precision medicine. However, there is a lac
Externí odkaz:
https://doaj.org/article/2be7e99c676a450782c0e39431b9e40d
Autor:
Kate Connor, Emer Conroy, Kieron White, Liam P. Shiels, Simon Keek, Abdalla Ibrahim, William M. Gallagher, Kieron J. Sweeney, James Clerkin, David O’Brien, Jane B. Cryan, Philip J. O’Halloran, Josephine Heffernan, Francesca Brett, Philippe Lambin, Henry C. Woodruff, Annette T. Byrne
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Here, we establish a CT-radiomics based method for application in invasive, orthotopic rodent brain tumour models. Twenty four NOD/SCID mice were implanted with U87R-Luc2 GBM cells and longitudinally imaged via contrast enhanced (CE-CT) imag
Externí odkaz:
https://doaj.org/article/f5502ff7e06945ad8173541c1ee43f95
Autor:
Ian S. Miller, Sonja Khan, Liam P. Shiels, Sudipto Das, Alice C. O' Farrell, Kate Connor, Adam Lafferty, Bruce Moran, Claudio Isella, Paul Loadman, Emer Conroy, Susan Cohrs, Roger Schibli, Robert S. Kerbel, William M. Gallagher, Elisabetta Marangoni, Kathleen Bennett, Darran P. O' Connor, Róisín M. Dwyer, Annette T. Byrne
Publikováno v:
Cancer Medicine, Vol 11, Iss 20, Pp 3820-3836 (2022)
Abstract Backgorund Prior data suggest pre‐diagnostic aspirin use impacts breast tumour biology and patient outcome. Here, we employed faithful surgical resection models of HER2+ and triple‐negative breast cancer (TNBC), to study outcome and resp
Externí odkaz:
https://doaj.org/article/1f5177ae512441ffab056e955c214925
Autor:
Federica Fabro, Trisha V. Kers, Kate J. Feller, Cecile Beerens, Ioannis Ntafoulis, Ahmed Idbaih, Maite Verreault, Kate Connor, Archita Biswas, Manuela Salvucci, Jochen H. M. Prehn, Annette T. Byrne, Alice C. O’Farrell, Diether Lambrechts, Gonca Dilcan, Francesca Lodi, Ingrid Arijs, Andreas Kremer, Romain Tching Chi Yen, Miao-Ping Chien, Martine L. M. Lamfers, Sieger Leenstra
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15678 (2023)
Chemotherapy using temozolomide is the standard treatment for patients with glioblastoma. Despite treatment, prognosis is still poor largely due to the emergence of temozolomide resistance. This resistance is closely linked to the widely recognized i
Externí odkaz:
https://doaj.org/article/8271d679ac384d7fb2b4f54037633904
Autor:
Oluwakanyinsolami Netufo, Kate Connor, Liam P. Shiels, Kieron J. Sweeney, Dan Wu, Donal F. O’Shea, Annette T. Byrne, Ian S. Miller
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 550 (2022)
Glioblastoma (GBM) is the most aggressive adult brain tumour with a dismal 2-year survival rate of 26–33%. Maximal safe resection plays a crucial role in improving patient progression-free survival (PFS). Neurosurgeons have the significant challeng
Externí odkaz:
https://doaj.org/article/4190d69ae8024e5081209c215033c399
Autor:
Kate Connor, David W. Murray, Monika A. Jarzabek, Nhan L. Tran, Kieron White, Patrick Dicker, Kieron J. Sweeney, Philip J. O’Halloran, Brian MacCarthy, Liam P. Shiels, Francesca Lodi, Diether Lambrechts, Jann N. Sarkaria, Raymond M. Schiffelers, Marc Symons, Annette T. Byrne
Publikováno v:
Cancers, Vol 12, Iss 12, p 3531 (2020)
Glioblastoma (GBM), a highly invasive and vascular malignancy is shown to rapidly develop resistance and evolve to a more invasive phenotype following bevacizumab (Bev) therapy. Rho Guanine Nucleotide Exchange Factor proteins (RhoGEFs) are mediators
Externí odkaz:
https://doaj.org/article/7ac5f7cfc58347c6ba7ff0bd62f0c37c
Autor:
Alice C. O’Farrell, Monika A. Jarzabek, Andreas U. Lindner, Steven Carberry, Emer Conroy, Ian S. Miller, Kate Connor, Liam Shiels, Eugenia R. Zanella, Federico Lucantoni, Adam Lafferty, Kieron White, Mariangela Meyer Villamandos, Patrick Dicker, William M. Gallagher, Simon A. Keek, Sebastian Sanduleanu, Philippe Lambin, Henry C. Woodruff, Andrea Bertotti, Livio Trusolino, Annette T. Byrne, Jochen H. M. Prehn
Publikováno v:
Cancers, Vol 12, Iss 10, p 2978 (2020)
Resistance to chemotherapy often results from dysfunctional apoptosis, however multiple proteins with overlapping functions regulate this pathway. We sought to determine whether an extensively validated, deterministic apoptosis systems model, ‘DR_M
Externí odkaz:
https://doaj.org/article/ea5a96ef8f444a88b82dbd3caf5d5111
Autor:
Archita Biswas, Manuela Salvucci, Kate Connor, Heiko Düssmann, Steven Carberry, Michael Fichtner, Ellen King, Brona Murphy, A.C O’Farrell, Jane Cryan, Alan Beausang, Josephine Heffernan, Mattia Cremona, Bryan T. Hennessy, James Clerkin, Kieron J. Sweeney, Steve MacNally, F Brett, P O’Halloran, Orna Bacon, Simon Furney, Maite Verreault, Emie Quissac, Franck Bielle, Mohammed H Ahmed, Ahmed Idbaih, Sieger Leenstra, Ioannis Ntafoulis, Federica Fabro, Martine Lamfers, Anna Golebiewska, Frank Hertel, Simone P Niclou, Romain Tching Chi Yen, Andreas Kremer, Gonca Dilcan, Francesca Lodi, Ingrid Arijs, Diether Lambrechts, Manasa Kalya P, Alexander Kel, Annette T Byrne, Jochen H.M Prehn
Publikováno v:
Journal of Neuro-Oncology.
Background Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited advances in finding new treatments for GBM. In this study, we investigated molecular differenc
Autor:
James Clerkin, Kate Connor, Kieron White, Kieron Sweeney, Liam Shiels, Thomas Van Brussel, Ingrid Arijs, Diether Lambrechts, Stephen Maher, Laure Marignol, Jochen Prehn, David O'Brien, Annette Byrne
Publikováno v:
Neuro-Oncology. 24:vii296-vii297
Clinically faithful pre-clinical models are essential for screening therapies and studying resistance mechanisms. Historically models have failed to predict response in the clinical setting. Current models seldom incorporate surgical resection, and c
Autor:
Kate Connor, Emer Conroy, Kieron White, Liam Shiels, Simon Keek, Abdalla Ibrahim, William Gallagher, James Clerkin, Kieron Sweeney, David O'Brien, Jane Cryan, Josephine Heffernan, Francesca Brett, Philippe Lambin, Henry Woodruff, Annette Byrne
Publikováno v:
Neuro-Oncology. 24:vii295-vii296
While magnetic resonance imaging (MRI) is the predominant imaging modality for glioblastoma (GBM), pre-clinical MRI scanner availability is limited. As pre-clinical CT is more widely available and cost-effective, this study aimed to 1) establish prec