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pro vyhledávání: '"Kate C. Shen"'
Autor:
Chu-Xia Deng, Samuel C. Brooks, Shu Lu, Y. Alan Wang, Henry H.Q. Heng, Kate C. Shen, Yaolin Wang, Guo Liu
Publikováno v:
Cancer research. 65(19)
The DNA damage checkpoint protein kinase mutated in ataxia telangiectasia (ATM) is involved in sensing and transducing DNA damage signals by phosphorylating and activating downstream target proteins that are implicated in the regulation of cell cycle
Publikováno v:
Human molecular genetics. 14(20)
Atm is a stress-induced DNA damage checkpoint protein kinase with multiple roles in cell-cycle progression. Recent evidence indicates that Atm also plays a role in stem cell maintenance and self-renewal. It is not known whether Atm has a role during
Autor:
Kate C. Shen, Myong Joon Hahn, Y. Alan Wang, Yaolin Wang, Samuel C. Brooks, Zhongliang Jiang, Yeugeniya Kamarova
Publikováno v:
Cancer biologytherapy. 4(10)
Genome stability maintenance is regulated by both genetic and epigenetic mechanisms. DNA methylation is the predominant epigenetic mechanism in regulation of gene expression and in suppression of mobile DNA elements from random integration in the gen