Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kate Broderick"'
Autor:
Alison Generotti, Ryne Contreras, Brenden Zounes, Eric Schade, Andrea Kemme, Yatish Rane, Xinggang Liu, Dustin Elwood, Katherine Schultheis, Jeremy Marston, Jay McCoy, Kate Broderick, Paul Fisher
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102070- (2023)
Intradermal delivery of DNA vaccines via electroporation (ID-EP) has shown clinical promise, but the use of needle electrodes is typically required to achieve consistent results. Here, delivery of a DNA vaccine targeting the Middle East Respiratory S
Externí odkaz:
https://doaj.org/article/410d3ecf4cff4763b4f611534e4e5a2e
Autor:
Sheng Jiang, Shuting Wu, Gan Zhao, Yue He, Linlin Bao, Jiangning Liu, Chuan Qin, Jiawang Hou, Yuan Ding, Alex Cheng, Brian Jiang, John Wu, Jian Yan, Laurent Humeau, Ami Patella, David B. Weiner, Kate Broderick, Bin Wang
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 18, Iss 1 (2022)
Genetic optimization of Nucleic Acid immunogens is important for potentially improving their immune potency. A COVID-19 DNA vaccine is in phase III clinical trial which is based on a promising highly developable technology platform. Here, we show opt
Externí odkaz:
https://doaj.org/article/d80f080d51284b6b80ece230e98afed6
Autor:
Matthew P Morrow, Kimberly A Kraynyak, Albert J Sylvester, Xuefei Shen, Dinah Amante, Lindsay Sakata, Lamar Parker, Jian Yan, Jean Boyer, Christian Roh, Laurent Humeau, Amir S Khan, Kate Broderick, Kathleen Marcozzi-Pierce, Mary Giffear, Jessica Lee, Cornelia L Trimble, J Joseph Kim, Niranjan Y Sardesai, David B Weiner, Mark L Bagarazzi
Publikováno v:
Molecular Therapy: Oncolytics, Vol 3, Iss C (2016)
We have previously demonstrated the immunogenicity of VGX-3100, a multicomponent DNA immunotherapy for the treatment of Human Papillomavirus (HPV)16/18-positive CIN2/3 in a phase 1 clinical trial. Here, we report on the ability to boost immune respon
Externí odkaz:
https://doaj.org/article/6cdec84404f44e6da5cce111757a5347
Autor:
James B. Thomas, Haley Slook, Haley Allison, Joshua Holtz, Paul H. Lewis, Andrew Le Blanc, Juan Lopez, Jonathan A. Simmons, Paul Fisher, Jeremy Marston, Justin R. Davis, Kate Broderick
Publikováno v:
Journal of Controlled Release. 307:200-210
This paper presents results from an ex-vivo study of intradermal jet injections, which is an attractive method to achieve both needle-free and fractional dose delivery of vaccines. Due to the fact that fluid properties of many novel therapeutics and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa573028e0ab5062ea5f3731acd1f725
https://doi.org/10.1016/j.jconrel.2019.06.032
https://doi.org/10.1016/j.jconrel.2019.06.032
Autor:
Dinah Amante, Maria Yang, Jared Tur, Arthur Doan, Igor Maricic, Blake Schouest, Zeena Eblimit, Patrick Pezzoli, Trevor R.F. Smith, Megan Lok, Katherine Schultheis, Swagata Kar, David B. Weiner, Maciel Porto, Brittany Spence, Fader J, Viviane M Andrade, J. Joseph Kim, Richa Kalia, Laurent Humeau, Ferrer R, Dustin Elwood, Stephanie Ramos, Charles C. Reed, Kate Broderick, Horn H, Miguel Vazquez, Bradette H, Jewell Walters, Brandon Narvaez
Here we have employed SynCon® design technology to construct a DNA vaccine expressing a pan-Spike immunogen (INO-4802) to induce broad immunity across SARS-CoV-2 variants of concern (VOC). Compared to WT and VOC-matched vaccines which showed reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4e1492c32118edc0ca564439e5b1697
https://doi.org/10.1101/2021.05.11.443592
https://doi.org/10.1101/2021.05.11.443592
Autor:
Daniel W. Kulp, Megan C. Wise, Jianqiu Du, Lauren Gites, Jesper Pallesen, Ishaan Patel, Emma L. Reuschel, Trevor R.F. Smith, Edgar Tello-Ruiz, David B. Weiner, Alan Moore, Yuanhan Wu, Mansi Purwar, Ziyang Xu, Kate Broderick, April Obeirne, Susanne Walker, Janess M. Mendoza, Katherine Schultheis, Sonali Majumdar, Faraz I. Zaidi, Neethu Chokkalingam, Laurent H. Humeau
Despite extensive efforts, an efficacious HIV vaccine remains elusive. HIV Envelope (Env) is the target of all known neutralizing antibodies. Stabilizing Env into native-like trimer (NLT) conformations is required for recombinant protein immunogens t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6de08d3e5b89440a423d051730e3b386
https://doi.org/10.21203/rs.3.rs-275402/v1
https://doi.org/10.21203/rs.3.rs-275402/v1
Autor:
Kate Broderick, Jay Mccoy, Trevor R.F. Smith, William B. Kiosses, J Oh, Paul Fisher, Katherine Schultheis, Janess M. Mendoza, Carlos J Brambila, Bryan S. Yung
Publikováno v:
Gene Therapy
DNA vaccines delivered using electroporation (EP) have had clinical success, but these EP methods generally utilize invasive needle electrodes. Here, we demonstrate the delivery and immunogenicity of a DNA vaccine into subcutaneous adipose tissue cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e44eca2f3698b33d8741a85e6459db
https://doi.org/10.1038/gt.2017.96
https://doi.org/10.1038/gt.2017.96
Autor:
Lumena, Louis, Megan, Clark, Megan C, Wise, Nelson, Glennie, Andrea, Wong, Kate, Broderick, Jude, Uzonna, David B, Weiner, Phillip, Scott
Publikováno v:
Infection and immunity. 87(8)
Vaccination remains one of the greatest medical breakthroughs in human history and has resulted in the near eradication of many formerly lethal diseases in many countries, including the complete eradication of smallpox. However, there remain a number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f93e0feb9376543e948669709810f4b
https://pubmed.ncbi.nlm.nih.gov/31182618
https://pubmed.ncbi.nlm.nih.gov/31182618
Autor:
Kathy Abascal, Yaser Abdelhamid, Zemphira Alavidze, Jason Allen, Lise Alschuler, Steve Austin, Jeff Baker, Peter W. Bennett, Bob G. Blasdel, Peter B. Bongiorno, Dennis N. Bourdette, Rachelle S. Bradley, J. Alexander Bralley, Kate Broderick, Carlo Calabrese, Alan Christianson, Anthony J. Cichoke, George W. Cody, Kevin L. Conroy, Walter J. Crinnion, T. Michael Culp, Peter J. D’Adamo, Zora DeGrandpre, Rhonda Dorren, Mark Dreher, John R. Endres, Geovanni Espinosa, Cathryn M. Flanagan, Alan R. Gaby, Leo Galland, Susan A. Gaylord, Andrea Girman, Alan Goldhamer, Mark D. Groven, Patrick Hanaway, Heidi Hascall, Jason Hawrelak, Leah Hechtman, Stephen Helms, Wendy Hodsdon, Tori Hudson, Corene Humphreys, Aimee Huyck, Tim Irving, Mary James, Kelly Jennings, Herb Joiner-Bey, David S. Jones, Tina Kaczor, Parris M. Kidd, Richard Kitaeff, Thomas A. Kruzel, Sarah J. Kuhl, Elizabeth Kutter, Andrew Lange, Rick Liva, Pina LoGiudice, Richard S. Lord, John C. Lowe, Michael Lyon, Douglas 'Duffy' Mackay, Robert M. Martinez, L. Charles Masur, Steven C. Milkis, Laurie K. Mischley, Gaetano Morello, Gerard Mullin, Stephen P. Myers, Paul J. Nicolai, Mark H. Nolting, Melissa Palmer, Cristiana Paul, Lara Pizzorno, Dirk Powell, David Quig, Sheila Quinn, Irfan Qureshi, Ronald G. Reichert, Paul Reilly, Corey Resnick, Sally J. Rockwell, Robert A. Ronzio, Sam Russo, Angela Sadlon, Trevor K. Salloum, Alexander G. Schauss, Lynne Shinto, Barbara Siminovich-Blok, Pamela Snider, Virender Sodhi, Nick Soloway, Nancy Sudak, Jade Teta, Keoni Teta, Sherry Torkos, Jessica Tran, Michael Traub, Terry Willard, Michelle M. Wong, Vijayshree Yadav, Eric L. Yarnell, Gregory T. Yasuda, Jared L. Zeff, Ira D. Zunin, Heather Zwickey
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a5620f144b0c99b57d620975b5bb905
https://doi.org/10.1016/b978-1-4377-2333-5.01002-6
https://doi.org/10.1016/b978-1-4377-2333-5.01002-6