Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Kate Blease"'
Autor:
Alexander C. Leeksma, Ingrid A. M. Derks, Brett Garrick, Aldo Jongejan, Martino Colombo, Timon Bloedjes, Torsten Trowe, Jim C. Leisten, Michelle Howarth, Mehnaz Malek, Deborah S. Mortensen, Kate Blease, Mathew C. Groza, Rama Krishna Narla, Remco Loos, Marie‐José Kersten, Perry D. Moerland, Jeroen E. J. Guikema, Arnon P. Kater, Eric Eldering, Ellen H. Filvaroff
Publikováno v:
Molecular Oncology, Vol 17, Iss 2, Pp 284-297 (2023)
Early data suggested that CC‐115, a clinical molecule, already known to inhibit the mammalian target of rapamycin kinase (TORK) and DNA‐dependent protein kinase (DNA‐PK) may have additional targets beyond TORK and DNA‐PK. Therefore, we aimed
Externí odkaz:
https://doaj.org/article/702d5efc32b54942a82e101ab9e8166c
Autor:
Mingjun Zhang, Michael Haughey, Nai-Yu Wang, Kate Blease, Ann M Kapoun, Suzana Couto, Igor Belka, Timothy Hoey, Matthew Groza, James Hartke, Brydon Bennett, Jennifer Cain, Austin Gurney, Brent Benish, Paola Castiglioni, Clifton Drew, Jean Lachowicz, Leon Carayannopoulos, Steven D Nathan, Jorg Distler, David A Brenner, Kandasamy Hariharan, Ho Cho, Weilin Xie
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229445 (2020)
The Wnt/β-catenin signaling pathway has been implicated in human proliferative diseases such as cancer and fibrosis. The functions of β-catenin and several other components of this pathway have been investigated in fibrosis. However, the potential
Externí odkaz:
https://doaj.org/article/0d7f69de1072458fb78965ae68d70c9c
Autor:
Gregory D Ferguson, Mercedes Delgado, Veronique Plantevin-Krenitsky, Kristen Jensen-Pergakes, R J Bates, Sanaa Torres, Maria Celeridad, Heather Brown, Kelven Burnett, Lisa Nadolny, Lida Tehrani, Garrick Packard, Barbra Pagarigan, Jason Haelewyn, Trish Nguyen, Li Xu, Yang Tang, Matthew Hickman, Frans Baculi, Steven Pierce, Keiji Miyazawa, Pilgrim Jackson, Philip Chamberlain, Laurie LeBrun, Weilin Xie, Brydon Bennett, Kate Blease
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0145705 (2016)
Autoantibodies and the immunoreceptors to which they bind can contribute to the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). Spleen Tyrosine Kinase (Syk) is a non-receptor tyrosine kinase with a central role in immunorecepto
Externí odkaz:
https://doaj.org/article/500fb09ba236468db438ca0053bf54d2
Autor:
Alexander C. Leeksma, Ingrid A. M. Derks, Brett Garrick, Aldo Jongejan, Martino Colombo, Timon Bloedjes, Torsten Trowe, Jim C. Leisten, Michelle Howarth, Mehnaz Malek, Deborah S. Mortensen, Kate Blease, Mathew C. Groza, Rama Krishna Narla, Remco Loos, Marie‐José Kersten, Perry D. Moerland, Jeroen E. J. Guikema, Arnon P. Kater, Eric Eldering, Ellen H. Filvaroff
Publikováno v:
Molecular oncology. Elsevier
Leeksma, A C, Derks, I A M, Garrick, B, Jongejan, A, Colombo, M, Bloedjes, T, Trowe, T, Leisten, J C, Howarth, M, Malek, M, Mortensen, D S, Blease, K, Groza, M C, Narla, R K, Loos, R, Kersten, M-J, Moerland, P D, Guikema, J E J, Kater, A P, Eldering, E & Filvaroff, E H 2022, ' SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma ', Molecular oncology . https://doi.org/10.1002/1878-0261.13343
Leeksma, A C, Derks, I A M, Garrick, B, Jongejan, A, Colombo, M, Bloedjes, T, Trowe, T, Leisten, J C, Howarth, M, Malek, M, Mortensen, D S, Blease, K, Groza, M C, Narla, R K, Loos, R, Kersten, M-J, Moerland, P D, Guikema, J E J, Kater, A P, Eldering, E & Filvaroff, E H 2022, ' SMG1, a nonsense-mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma ', Molecular oncology . https://doi.org/10.1002/1878-0261.13343
Early data suggested that CC-115, a clinical molecule, already known to inhibit the mammalian target of rapamycin kinase (TORK) and DNA-dependent protein kinase (DNA-PK) may have additional targets beyond TORK and DNA-PK. Therefore, we aimed to ident
Autor:
Mark A. Nagy, Robert Hilgraf, Deborah S. Mortensen, Jan Elsner, Stephen Norris, Jayashree Tikhe, Won Yoon, David Paisner, Mercedes Delgado, Paul Erdman, Jason Haelewyn, Godrej Khambatta, Li Xu, William J. Romanow, Kevin Condroski, Sogole Bahmanyar, Meg McCarrick, Brent Benish, Kate Blease, Laurie LeBrun, Mehran F. Moghaddam, Julius Apuy, Stacie S. Canan, Brydon L. Bennett, Yoshitaka Satoh
Publikováno v:
Journal of Medicinal Chemistry. 64:18193-18208
Autor:
Kate Blease, Garth Ringheim, Eduardo Torres, Jeffrey Muir, Laurie LeBrun, Veronique Plantevin-Krenitsky, Ashutosh Kulkarni, Maria Celeridad, Eun Mi Hur, Hegde Sayee Gajanan, Dehua Huang, Brian E. Cathers, John Sapienza, Henry Chan, Brydon Bennett, Katerina Leftheris, Correa Matthew D, Zheng Liu, Deborah S Mortensen, Brandon Whitefield, Mercedes Delgado, Dan Cashion, Sogole Bahmanyar, Lisa Morrison, Roli Khattri, Jason Parnes, Stephen Norris, Roy Harris, Kelven Burnett, Joshua Hansen, Godrej Khambatta, Patrick Papa
Publikováno v:
Journal of Medicinal Chemistry. 64:11886-11903
The PKC-θ isoform of protein kinase C is selectively expressed in T lymphocytes and plays an important role in the T cell antigen receptor (TCR)-triggered activation of mature T cells, T cell proliferation, and the subsequent release of cytokines su
Autor:
null Alexander C. Leeksma, null Ingrid A.M. Derks, null Brett Garrick, null Aldo Jongejan, null Martino Colombo, null Timon Bloedjes, null Torsten Trowe, null Jim C. Leisten, null Michelle Howarth, null Mehnaz Malek, null Deborah S. Mortensen, null Kate Blease, null Mathew C. Groza, null Rama Krishna Narla, null Remco Loos, null Marie‐José Kersten, null Perry D. Moerland, null Jeroen E.J. Guikema, null Arnon P. Kater, null Eric Eldering, null Ellen H. Filvaroff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b140e3e634f7c3b24cd9a9e52bc733
https://doi.org/10.1002/1878-0261.13343/v2/response1
https://doi.org/10.1002/1878-0261.13343/v2/response1
Autor:
Weilin Xie, Jean Lachowicz, Timothy Hoey, Igor Belka, Paola Castiglioni, James Hartke, Steven D. Nathan, Leon Carayannopoulos, David A. Brenner, Matthew C. Groza, Ann M. Kapoun, Cho Ho, Nai-Yu Wang, Austin L. Gurney, Mingjun Zhang, Brent Benish, Jörg H W Distler, Michael Haughey, Jennifer Cain, Kate Blease, Suzana Couto, Brydon L. Bennett, Hariharan Kandasamy, Clifton Drew
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0229445 (2020)
PLoS ONE, Vol 15, Iss 3, p e0229445 (2020)
The Wnt/β-catenin signaling pathway has been implicated in human proliferative diseases such as cancer and fibrosis. The functions of β-catenin and several other components of this pathway have been investigated in fibrosis. However, the potential
Autor:
Mariko Riley, Katie Stamp, Xinde Zheng, Yan Ren, Kate Blease, Chin-Chun Lu, Julia Hui, Lawrence G Hamann, Philip P Chamberlain, Gang Lu, Polat Abdubek, Mary E Matyskiela, Gondi Kumar, Maria Wang, Wei Fang, Aaron Carpenter, Thomas Clayton, Clifton Drew, Suzana Couto, Chung-Wein Lee, Mark Rolfe, Rupert Vessey, James Hartke
Publikováno v:
Nature Chemical Biology. 14:981-987
Targeted protein degradation via small-molecule modulation of cereblon offers vast potential for the development of new therapeutics. Cereblon-binding therapeutics carry the safety risks of thalidomide, which caused an epidemic of severe birth defect
Publikováno v:
Life Sciences. 146:192-200
Aims Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase involved in the signalling pathways of the B cell receptor, Fcγ-receptor and some leukocyte integrins. However, Syk can also be expressed by some non-haematopoietic cell types, alth