Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Kate A. Murphy"'
Autor:
Michael J. McKenna, Xiaofei Gong, Aaron C. Petersen, Simon Sostaric, Craig A. Goodman, Andrew Garnham, Tai‐Juan Aw, Collene H. Steward, Kate T. Murphy, Kate A. Carey, Henry Krum, Rodney J. Snow, David Cameron‐Smith
Publikováno v:
Experimental Physiology, Vol 109, Iss 11, Pp 1909-1921 (2024)
Abstract In muscle, digoxin inhibits Na+,K+‐ATPase (NKA) whereas acute exercise can increase NKA gene expression, consistent with training‐induced increased NKA content. We investigated whether oral digoxin increased NKA isoform mRNA expression (
Externí odkaz:
https://doaj.org/article/cbd1bcf324d54266bf9e079ca206dcb1
Autor:
Kate T. Murphy, Gordon S. Lynch
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 5, Pp 1987-2002 (2023)
Abstract There is increasing evidence that neurodegenerative disorders including the Parkinsonian syndromes are associated with impaired skeletal muscle health, manifesting as wasting and weakness. Many of the movement problems, lack of muscle streng
Externí odkaz:
https://doaj.org/article/06d69cb2c9bf41069bc3c2811f87f35f
Autor:
Kate T. Murphy, Kristy Swiderski, James G. Ryall, Jonathan R. Davey, Hongwei Qian, Séverine Lamon, Victoria C. Foletta, Jennifer Trieu, Annabel Chee, Suzannah J. Read, Timur Naim, Paul Gregorevic, Gordon S. Lynch
Publikováno v:
JCSM Rapid Communications, Vol 5, Iss 1, Pp 102-116 (2022)
Abstract Background Cachexia is a debilitating complication of cancer characterized by progressive wasting and weakness of skeletal muscles that reduces quality of life and can compromise survival. Many anticancer treatments, such as chemotherapy, al
Externí odkaz:
https://doaj.org/article/4b80acbe02104dee8ebddccaedd7c9ba
Autor:
Wenlan Li, Jennifer Trieu, Ronnie Blazev, Benjamin L. Parker, Kate T. Murphy, Kristy Swiderski, Gordon S. Lynch
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C205-C221
Cancer cachexia is common in many cancers and the loss of skeletal muscle mass compromises the response to therapies and quality of life. A contributing mechanism is oxidative stress and compounds able to attenuate it may be protective. Sulforaphane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb2b2753a82b96b21ad67f74a382107
https://doi.org/10.1152/ajpcell.00025.2022
https://doi.org/10.1152/ajpcell.00025.2022
Publikováno v:
Antioxidants, Vol 11, Iss 2, p 183 (2022)
Cancer cachexia is the progressive muscle wasting and weakness experienced by many cancer patients. It can compromise the response to gold standard cancer therapies, impair functional capacity and reduce overall quality of life. Cancer cachexia accou
Externí odkaz:
https://doaj.org/article/254d63530b034ff2aa3c1f7dd96dcc3c
Autor:
Simon Sostaric, Aaron C. Petersen, Craig A. Goodman, Xiaofei Gong, Tai‐Juan Aw, Malcolm J. Brown, Andrew Garnham, Collene H. Steward, Kate T. Murphy, Kate A. Carey, James Leppik, Steve F. Fraser, David Cameron‐Smith, Henry Krum, Rodney J. Snow, Michael J. McKenna
Publikováno v:
The Journal of Physiology. 600:3749-3774
We investigated whether digoxin lowered muscle Na+,K+-ATPase (NKA), impaired muscle performance and exacerbated exercise K+ disturbances. Ten healthy adults ingested digoxin (0.25 mg; DIG) or placebo (CON) for 14 days and performed quadriceps strengt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151a4a2b5a869874a56f3fbc053ae003
https://doi.org/10.1113/jp283017
https://doi.org/10.1113/jp283017
Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle
Autor:
Robert S. Lee-Young, Nolan J. Hoffman, Kate T. Murphy, Darren C. Henstridge, Dorit Samocha-Bonet, Andrew L. Siebel, Peter Iliades, Borivoj Zivanovic, Yet H. Hong, Timothy D. Colgan, Michael J. Kraakman, Clinton R. Bruce, Paul Gregorevic, Glenn K. McConell, Gordon S. Lynch, Grant R. Drummond, Bronwyn A. Kingwell, Jerry R. Greenfield, Mark A. Febbraio
Publikováno v:
Molecular Metabolism, Vol 5, Iss 11, Pp 1083-1091 (2016)
Objective: The development of skeletal muscle insulin resistance is an early physiological defect, yet the intracellular mechanisms accounting for this metabolic defect remained unresolved. Here, we have examined the role of glucose-6-phosphate dehyd
Externí odkaz:
https://doaj.org/article/b7a0d2f504b14b63ab5ea39dfdc8387f
Autor:
Gordon S. Lynch, Andrew R. Judge, Jose G. Trevino, Sarah M. Judge, David I. Stapleton, Suzannah J. Read, Vanessa Haynes, Jennifer Trieu, Timur Naim, Annabel Chee, Kristy Swiderski, Mohammed I. Hossain, Kate T. Murphy
Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal muscle mass associated with significant functional impairment. Cachexia robs patients of their strength and capacity to perform daily tasks and live independ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b029670edc8b2cd2e71872d139bed4
https://doi.org/10.1158/0008-5472.c.6511214.v1
https://doi.org/10.1158/0008-5472.c.6511214.v1
Autor:
Gordon S. Lynch, Andrew R. Judge, Jose G. Trevino, Sarah M. Judge, David I. Stapleton, Suzannah J. Read, Vanessa Haynes, Jennifer Trieu, Timur Naim, Annabel Chee, Kristy Swiderski, Mohammed I. Hossain, Kate T. Murphy
This file contains: • Supplemental Methods • Supplemental Figure S1. Muscle-specific overexpression of the AT1 but not the MasR regulates skeletal muscle fiber size in healthy mice. • Supplemental Figure S2. Representative images of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b900cc1b0ac26bfb6a2eea6bd5b6c51
https://doi.org/10.1158/0008-5472.22422416.v1
https://doi.org/10.1158/0008-5472.22422416.v1
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 4, Pp 533-545 (2012)
SUMMARY Cancer cachexia describes the progressive skeletal muscle wasting and weakness that is associated with many cancers. It impairs quality of life and accounts for >20% of all cancer-related deaths. The main outcome that affects quality of life
Externí odkaz:
https://doaj.org/article/f59df4eb53b74a65ab31ebf335659d75