Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kate A. Dwornik"'
Autor:
Pierette Banker, Daphne C. Clancy, Francis X. Tavares, Pamela L. Golden, Liping Wang, James E. Weiel, Steven M. Sparks, Stephen A. Thomson, Lauren R. Sheckler, Dulce Garrido, Scott Howard Dickerson, Andrew J. Peat, David M. Bickett, H. Luke Carter, Kate A. Dwornik, Robert T. Nolte
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:976-980
Optimization of the amino acid residue within a series of anthranilimide-based glycogen phosphorylase inhibitors is described. These studies culminated in the identification of anthranilimides 16 and 22 which displayed potent in vitro inhibition of G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccab5b862050e9a20580b438b03c30f9
https://doi.org/10.1016/j.bmcl.2008.11.085
https://doi.org/10.1016/j.bmcl.2008.11.085
Autor:
Aaron B. Miller, Steve Blanchard, Kate A. Dwornik, Dallas K. Croom, Robert T. Gampe, Tom G. Consler, James M. Lenhard, Olivia Ittoop, Valerie G. Montana, Randy K. Bledsoe, and Andrea Ayscue, Darryl Lynn Mcdougald, Curt D. Haffner, H. Eric Xu
Publikováno v:
Journal of Medicinal Chemistry. 47:2010-2029
A series of tetrahydrobenzofuranyl and tetrahydrobenzothienyl propenoic acids that showed potent agonist activity against RXRalpha were synthesized via a structure-based design approach. Among the compounds studied, 46a,b showed not only very good po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37272a91a5f51d032982fc530dd7de0b
https://doi.org/10.1021/jm030565g
https://doi.org/10.1021/jm030565g
Autor:
Claude R. Jones, Kate A. Dwornik, John T. Gupton, James A. Sikorski, Karen X. Du, Phong Vu, Marian Vargas, Kartik M. Keertikar, Kirsten N. Hosein, Bruce S. Burnham, Keith Krumpe, Marc A. Bruce, Scott A. Petrich
Publikováno v:
Tetrahedron. 54:5075-5088
Reactions of 2,3-disubstituted chloropropeniminium salts and related synthons with ethyl glycinate, ethyl N-methylglycinate, and ethyl N-benzylglycinate have been studied under acidic, basic and neutral conditions. Such reactions have resulted in eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5c434371711702aeb5e1d1e68ad24c6
https://doi.org/10.1016/s0040-4020(98)00247-6
https://doi.org/10.1016/s0040-4020(98)00247-6
Autor:
Andrew J. Peat, Aaron S. Goetz, David F. Corbett, Dulce Garrido, Steve C. McKeown, Thomas R. Littleton, Celia P. Briscoe, Wendy Y. Mills, Kate A. Dwornik, Terrence L. Smalley
Publikováno v:
ChemInform. 37
The first report on the identification and structure–activity relationships of a novel series of GPR40 agonists based on a 3-(4-{[ N -alkyl]amino}phenyl)propanoic acid template is described. Structural modifications to the original screening hit yi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd14f636b934a5bf6d1ec3457298634a
https://doi.org/10.1002/chin.200627081
https://doi.org/10.1002/chin.200627081