Immunogenicity and mechanisms of action of PnuBioVax, a multi-antigen serotype-independent prophylactic vaccine against infection with Streptococcus pneumoniae

Autor: Sue Hill, Michael Joachim, Yin Pang, Ann McIlgorm, Jeremy S. Brown, Camilo A. Colaco, Kate A. Dalton, Christopher Bailey, David Goldblatt, Claire Entwisle, Polly Burbidge

Publikováno v: Vaccine. 36(29)

Streptococcus pneumoniae has multiple protein antigens on the surface in addition to the serotype specific polysaccharide capsule antigen. Whilst the capsule antigen is the target of the polysaccharide vaccines, bacterial proteins can also act as tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67edf8b9bb40a0575bd07fa8f7624065
https://pubmed.ncbi.nlm.nih.gov/29895498

A novel compartment, the ?subapical stem? of the aerial hyphae, is the location of a sigN-dependent, developmentally distinct transcription in Streptomyces coelicolor

Autor: Kate A. Dalton, James I. B. Hunter, Annabelle Thibessard, Gabriella H. Kelemen

Publikováno v: Molecular Microbiology. 64:719-737

Streptomyces coelicolor has nine SigB-like RNA polymerase sigma factors, several of them implicated in morphological differentiation and/or responses to different stresses. One of the nine, SigN, is the focus of this article. A constructed sigN null

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633393dcf8900c31708f257a82fa63aa
https://doi.org/10.1111/j.1365-2958.2007.05684.x

Coiled-coil protein Scy is a key component of a multiprotein assembly controlling polarized growth in Streptomyces

Autor: Gabriella H. Kelemen, Michael D. Gillespie, Andrew M. Hemmings, Neil A. Holmes, Annabelle Thibessard, Kate A. Dalton, John Walshaw, Bertolt Gust, Richard M. Leggett

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (5), pp.E397-E406. ⟨10.1073/pnas.1210657110⟩

Polarized growth in eukaryotes requires polar multiprotein complexes. Here, we establish that selection and maintenance of cell polarity for growth also requires a dedicated multiprotein assembly in the filamentous bacterium, Streptomyces coelicolor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484b1eee7cf8f5bda7cf428b9765a427
https://hal.univ-lorraine.fr/hal-01477256/document

A service model of short-term case management for elderly people at risk of hospital admission

Autor: Jane V Evans, Kate L Dalton, Catherine L Wilson, Rosalyn M Roberts

Publikováno v: Australian health review : a publication of the Australian Hospital Association. 31(2)

This article presents the model of a short-term case management program focused on reducing emergency department presentations and unplanned hospital admissions for a targeted group of older people with complex care needs. As a semi-integrated health

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc708f2f48c06d94d3b77658e076c7c
https://pubmed.ncbi.nlm.nih.gov/17470037