Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kateřina Rohlenová"'
Autor:
Petra Hyroššová, Mirko Milošević, Josef Škoda, Jiří Vachtenheim Jr, Jakub Rohlena, Kateřina Rohlenová
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Targeting tumor metabolism for cancer therapy is an old strategy. In fact, historically the first effective cancer therapeutics were directed at nucleotide metabolism. The spectrum of metabolic drugs considered in cancer increases rapidly – clinica
Externí odkaz:
https://doaj.org/article/7f3eb304ecb0414fb421b1c7b882e62f
Autor:
Liliana Sokol, Anne Cuypers, Anh-Co K. Truong, Ann Bouché, Katleen Brepoels, Joris Souffreau, Katerina Rohlenova, Stefan Vinckier, Luc Schoonjans, Guy Eelen, Mieke Dewerchin, Laura P.M.H. de Rooij, Peter Carmeliet
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Translation of academic results into clinical practice is a formidable unmet medical need. Single-cell RNA-sequencing (scRNA-seq) studies generate long descriptive ranks of markers with predicted biological function, but without functional v
Externí odkaz:
https://doaj.org/article/492570d9ce634a2ab0014bdb23770e7c
Autor:
Vincent Geldhof, Laura P. M. H. de Rooij, Liliana Sokol, Jacob Amersfoort, Maxim De Schepper, Katerina Rohlenova, Griet Hoste, Adriaan Vanderstichele, Anne-Marie Delsupehe, Edoardo Isnaldi, Naima Dai, Federico Taverna, Shawez Khan, Anh-Co K. Truong, Laure-Anne Teuwen, François Richard, Lucas Treps, Ann Smeets, Ines Nevelsteen, Birgit Weynand, Stefan Vinckier, Luc Schoonjans, Joanna Kalucka, Christine Desmedt, Patrick Neven, Massimiliano Mazzone, Giuseppe Floris, Kevin Punie, Mieke Dewerchin, Guy Eelen, Hans Wildiers, Xuri Li, Yonglun Luo, Peter Carmeliet
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Tumor blood vessels contribute to cancer growth, invasion and metastasis. Here, by using single cell transcriptomics, the authors report an inventory of endothelial cell heterogeneity in patients with breast cancer, including a subtype that expresses
Externí odkaz:
https://doaj.org/article/f607566042124ddc85658b5b9cc9abac
Autor:
Zuzana Bielcikova, Jan Stursa, Ludmila Krizova, Lanfeng Dong, Jan Spacek, Stanislav Hlousek, Michal Vocka, Katerina Rohlenova, Olga Bartosova, Vladimir Cerny, Tomas Padrta, Michal Pesta, Pavel Michalek, Sona Stemberkova Hubackova, Katarina Kolostova, Eliska Pospisilova, Vladimir Bobek, Peter Klezl, Renata Zobalova, Berwini Endaya, Jakub Rohlena, Lubos Petruzelka, Lukas Werner, Jiri Neuzil
Publikováno v:
EClinicalMedicine, Vol 57, Iss , Pp 101873- (2023)
Summary: Background: Mitochondria present an emerging target for cancer treatment. We have investigated the effect of mitochondrially targeted tamoxifen (MitoTam), a first-in-class anti-cancer agent, in patients with solid metastatic tumours. Methods
Externí odkaz:
https://doaj.org/article/91ab15755d5b4f4c9326f015bc30ba5c
Autor:
Nadine V. Conchinha, Liliana Sokol, Laure-Anne Teuwen, Koen Veys, Sébastien J. Dumas, Elda Meta, Melissa García-Caballero, Vincent Geldhof, Rongyuan Chen, Lucas Treps, Mila Borri, Pauline de Zeeuw, Kim D. Falkenberg, Charlotte Dubois, Magdalena Parys, Laura P.M.H. de Rooij, Katerina Rohlenova, Jermaine Goveia, Luc Schoonjans, Mieke Dewerchin, Guy Eelen, Xuri Li, Joanna Kalucka, Peter Carmeliet
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100508- (2021)
Summary: Endothelial cells (ECs) harbor distinct phenotypical and functional characteristics depending on their tissue localization and contribute to brain, eye, lung, and muscle diseases such as dementia, macular degeneration, pulmonary hypertension
Externí odkaz:
https://doaj.org/article/b2b20f8ce4a04a3ca684810cddf10920
Autor:
Sébastien J. Dumas, Elda Meta, Nadine V. Conchinha, Liliana Sokol, Rongyuan Chen, Mila Borri, Laure-Anne Teuwen, Koen Veys, Melissa García-Caballero, Vincent Geldhof, Lucas Treps, Pauline de Zeeuw, Kim D. Falkenberg, Charlotte Dubois, Magdalena Parys, Laura P.M.H. de Rooij, Katerina Rohlenova, Jermaine Goveia, Luc Schoonjans, Mieke Dewerchin, Guy Eelen, Xuri Li, Joanna Kalucka, Peter Carmeliet
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100523- (2021)
Summary: Endothelial cells (ECs) exhibit phenotypic and functional tissue specificities, critical for studies in the vascular field and beyond. Thus, tissue-specific methods for isolation of highly purified ECs are necessary. Kidney, spleen, and test
Externí odkaz:
https://doaj.org/article/529c5dbb57f9412cbdc0d63bd57e2948
Autor:
Laure-Anne Teuwen, Laura P.M.H. De Rooij, Anne Cuypers, Katerina Rohlenova, Sébastien J. Dumas, Melissa García-Caballero, Elda Meta, Jacob Amersfoort, Federico Taverna, Lisa M. Becker, Nuphar Veiga, Anna Rita Cantelmo, Vincent Geldhof, Nadine V. Conchinha, Joanna Kalucka, Lucas Treps, Lena-Christin Conradi, Shawez Khan, Tobias K. Karakach, Stefaan Soenen, Stefan Vinckier, Luc Schoonjans, Guy Eelen, Steven Van Laere, Mieke Dewerchin, Luc Dirix, Massimiliano Mazzone, Yonglun Luo, Peter Vermeulen, Peter Carmeliet
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109253- (2021)
Summary: Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer and myeloid cells in tumors growing vi
Externí odkaz:
https://doaj.org/article/7dadc23d237d4576aa0fd412a6c1555b
Autor:
Liliana Sokol, Vincent Geldhof, Melissa García-Caballero, Nadine V. Conchinha, Sébastien J. Dumas, Elda Meta, Laure-Anne Teuwen, Koen Veys, Rongyuan Chen, Lucas Treps, Mila Borri, Pauline de Zeeuw, Kim D. Falkenberg, Charlotte Dubois, Magdalena Parys, Laura P.M.H. de Rooij, Jermaine Goveia, Katerina Rohlenova, Luc Schoonjans, Mieke Dewerchin, Guy Eelen, Xuri Li, Joanna Kalucka, Peter Carmeliet
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100489- (2021)
Summary: Endothelial cells (ECs) from the small intestine, colon, liver, and heart have distinct phenotypes and functional adaptations that are dependent on their physiological environment. Gut ECs adapt to low oxygen, heart ECs to contractile forces
Externí odkaz:
https://doaj.org/article/b2d1c9d6471848f7a2760df466f9d229
Autor:
James Dooley, Vasiliki Lagou, Jermaine Goveia, Anna Ulrich, Katerina Rohlenova, Nathalie Heirman, Tobias Karakach, Yulia Lampi, Shawez Khan, Jun Wang, Tom Dresselaers, Uwe Himmelreich, Marc J. Gunter, Inga Prokopenko, Peter Carmeliet, Adrian Liston
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107880- (2020)
Summary: Pancreatic cancer is a rare but fatal form of cancer, the fourth highest in absolute mortality. Known risk factors include obesity, diet, and type 2 diabetes; however, the low incidence rate and interconnection of these factors confound the
Externí odkaz:
https://doaj.org/article/575ffb0ba48a4cca8912c3a6e88a0296