Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models

Autor: Urszula Wojcik-Trechcinska, Krzysztof Goryca, Michal Kopczynski, Kazimiera Pysniak, Jerzy Ostrowski, Katarzyna Wojcik-Jaszczynska, Maria Kulecka, Zuzanna Sandowska-Markiewicz, Izabela Rumienczyk, Eliza Majewska, Malgorzata Statkiewicz, Karolina Pyziak, Magdalena Masiejczyk, Karol Bomsztyk, Michal Mikula, Tomasz Rzymski

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10204, p 10204 (2021)

Sepsis is the leading cause of death in intensive care units worldwide. Current treatments of sepsis are largely supportive and clinical trials using specific pharmacotherapy for sepsis have failed to improve outcomes. Here, we used the lipopolysacch

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