Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Katarzyna Wiktorska"'
Autor:
Aleksandra Żmuda, Weronika Kamińska, Marta Bartel, Karolina Głowacka, Maciej Chotkowski, Katarzyna Medyńska, Katarzyna Wiktorska, Maciej Mazur
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract A new type of hybrid polymer particles capable of carrying the cytostatic drug doxorubicin and labeled with a gallium compound was prepared. These microparticles consist of a core and a hydrogel shell, which serves as the structural matrix.
Externí odkaz:
https://doaj.org/article/ab0e9a71b2464c9a8c33992a92c88763
Autor:
Anna Pogorzelska, Maciej Mazur, Marta Świtalska, Joanna Wietrzyk, Dawid Sigorski, Krzysztof Fronczyk, Katarzyna Wiktorska
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 161, Iss , Pp 114490- (2023)
Female breast cancer is the most deadly cancer in women worldwide. The triple-negative breast cancer subtype therapies, due to the lack of specific drug targets, are still based on systemic chemotherapy with doxorubicin, which is burdened with severe
Externí odkaz:
https://doaj.org/article/7436444386414002955e1bdfb1625501
Autor:
Małgorzata Milczarek, Tomasz Cierpiał, Piotr Kiełbasiński, Milena Małecka-Giełdowska, Marta Świtalska, Joanna Wietrzyk, Maciej Mazur, Katarzyna Wiktorska
Publikováno v:
Molecules, Vol 28, Iss 15, p 5808 (2023)
Antimetabolites, especially 5-fluorouracil, are commonly used clinically to treat breast, colon, and other cancers. However, their side effects and inefficiency in monotherapy have prompted further searches for new combinations. Thus, the anticancer
Externí odkaz:
https://doaj.org/article/893d4dbcd99a4db0a763806046b6d9ed
Autor:
Wojciech Bocian, Beata Naumczuk, Magdalena Urbanowicz, Jerzy Sitkowski, Elżbieta Bednarek, Katarzyna Wiktorska, Anna Pogorzelska, Ewelina Wielgus, Lech Kozerski
Publikováno v:
Molecules, Vol 27, Iss 20, p 6946 (2022)
The understanding of the mechanism of Topo I inhibition by organic ligands is a crucial source of information that has led to the design of more effective and safe pharmaceuticals in oncological chemotherapy. The vast number of inhibitors that have b
Externí odkaz:
https://doaj.org/article/723e9304008a456483bf9f48a82cbe21
Autor:
Wojciech Bocian, Beata Naumczuk, Magdalena Urbanowicz, Jerzy Sitkowski, Anna Bierczyńska-Krzysik, Elżbieta Bednarek, Katarzyna Wiktorska, Małgorzata Milczarek, Lech Kozerski
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7471 (2021)
The compounds 7-ethyl-9-(N-methylamino)methyl-10-hydroxycamptothecin (2) and 7-ethyl-9-(N-morpholino)methyl-10-hydroxycamptothecin (3) are potential topoisomerase I poisons. Moreover, they were shown to have favorable anti-neoplastic effects on sever
Externí odkaz:
https://doaj.org/article/333cfa843c6943e8844782d6f38eeb5b
Publikováno v:
Molecules, Vol 26, Iss 10, p 3019 (2021)
Combination therapy is based on the beneficial effects of pharmacodynamic interaction (synergistic or additive) between combined drugs or substances. A considerable group of candidates for combined treatments are natural compounds (e.g., isothiocyana
Externí odkaz:
https://doaj.org/article/342f4ac23394460893da0fdc6c5899af
Publikováno v:
Nutrients, Vol 12, Iss 6, p 1559 (2020)
Breast cancer is the most prevalent type of cancer among women worldwide. There are several recommended methods of breast cancer prevention, including chemoprevention. There are several approved drugs used to prevent breast cancer occurrence or recur
Externí odkaz:
https://doaj.org/article/bca4edc3a71a401590a1bd99a1a9d4d9
Autor:
Lidia Śliwka, Katarzyna Wiktorska, Piotr Suchocki, Małgorzata Milczarek, Szymon Mielczarek, Katarzyna Lubelska, Tomasz Cierpiał, Piotr Łyżwa, Piotr Kiełbasiński, Anna Jaromin, Anna Flis, Zdzisław Chilmonczyk
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155772 (2016)
Multiple in vitro tests are widely applied to assess the anticancer activity of new compounds, including their combinations and interactions with other drugs. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay is one of the
Externí odkaz:
https://doaj.org/article/a772b63798ca4280bfa8fef6ecd6e43c
Autor:
Małgorzata Milczarek, Lidia Mielczarek, Katarzyna Lubelska, Aleksandra Dąbrowska, Zdzisław Chilmonczyk, Dariusz Matosiuk, Katarzyna Wiktorska
Publikováno v:
Molecules, Vol 23, Iss 11, p 3040 (2018)
Isothiocyanates (R-NCS) are sulphur-containing phytochemicals. The main source are plants of the Brassicaceae family. The best known plant-derived isothiocyanate is sulforaphane that has exhibited anticancer activity in both in vivo and in vitro stud
Externí odkaz:
https://doaj.org/article/24bea7ab970d4efb92719fd5ec32ef1b
Autor:
Aleksandra Dąbrowska, Tomasz Pieńko, Przemysław Taciak, Katarzyna Wiktorska, Zdzisław Chilmonczyk, Aleksander P. Mazurek, Adam Stasiulewicz
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 3231 (2018)
Here we present new derivatives of nucleoside reverse transcriptase inhibitors with a C20 fullerene. The computational chemistry methods used in this study evaluate affinity of designed compounds towards the HIV-1 reverse transcriptase (RT) binding s
Externí odkaz:
https://doaj.org/article/6206bd42b51b465d87061ad1d13d64d6