Výsledky vyhledávání - "Katarzyna Wachowicz"

Akademický článek

Protein kinase C theta is dispensable for suppression mediated by CD25+CD4+ regulatory T cells.

Autor: Kerstin Siegmund, Nikolaus Thuille, Katarzyna Wachowicz, Natascha Hermann-Kleiter, Gottfried Baier

Publikováno v: PLoS ONE, Vol 12, Iss 5, p e0175463 (2017)

The activation of conventional T cells upon T cell receptor stimulation critically depends on protein kinase C theta (PKCθ). However, its role in regulatory T (Treg) cell function has yet to be fully elucidated. Using siRNA or the potent and PKC fam

Externí odkaz: https://doaj.org/article/034b945e55364097930fdb8205dae8ba

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Akademický článek

Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells.

Autor: Katarzyna Wachowicz, Natascha Hermann-Kleiter, Marlies Meisel, Kerstin Siegmund, Nikolaus Thuille, Gottfried Baier

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96401 (2014)

Protein kinase C θ (PKCθ) is involved in signaling downstream of the T cell antigen receptor (TCR) and is important for shaping effector T cell functions and inflammatory disease development. Acquisition of Th1-like effector features by Th17 cells

Externí odkaz: https://doaj.org/article/0527c39ada1f4a6cb2f597609a992302

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Akademický článek

PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes.

Autor: Nikolaus Thuille, Katarzyna Wachowicz, Natascha Hermann-Kleiter, Sandra Kaminski, Friedrich Fresser, Christina Lutz-Nicoladoni, Michael Leitges, Margot Thome, Ramin Massoumi, Gottfried Baier

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e53709 (2013)

In T cells PKCθ mediates the activation of critical signals downstream of TCR/CD28 stimulation. We investigated the molecular mechanisms by which PKCθ regulates NFκB transactivation by examining PKCθ/β single and double knockout mice and observe

Externí odkaz: https://doaj.org/article/b1dfabdaa5b8404d82f6bee9d2a78395

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Akademický článek

The different function of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C.

Autor: Magdalena Zaremba-Czogalla, Katarzyna Piekarowicz, Katarzyna Wachowicz, Katarzyna Kozioł, Magda Dubińska-Magiera, Ryszard Rzepecki

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e32649 (2012)

Lamins' functions are regulated by phosphorylation at specific sites but our understanding of the role of such modifications is practically limited to the function of cdc 2 (cdk1) kinase sites in depolymerization of the nuclear lamina during mitosis.

Externí odkaz: https://doaj.org/article/e42e09c0a1624f0ebcb24604c0eec1e7

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PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription

Autor: Christina, Lutz-Nicoladoni, Lutz-Nicoladoni, Christina, Nikolaus, Thuille, Thuille, Nikolaus, Katarzyna, Wachowicz, Wachowicz, Katarzyna, Thomas, Gruber, Gruber, Thomas, Michael, Leitges, Leitges, Michael, Gottfried, Baier, Baier, Gottfried

Publikováno v: Immunology Letters

Highlights ► Conventional PKCα and PKCβ isotypes have overlapping functions in T cell activation signalling. ► PKCα and PKCβ cooperate functionally to mediate IL-2 gene expression.
The physiological functions of PKCα and PKCθ isotypes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::62871523bb3d10affc6ead30811ad310

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Protein kinase Cθ: the pleiotropic T-cell signalling intermediate

Autor: Katarzyna Wachowicz, Gottfried Baier

Publikováno v: Biochemical Society transactions. 42(6)

Activating as well as inhibitory circuits tightly regulate T-cell activation thresholds and effector differentiation processes enabling proper immune response outcomes. Recently, an additional molecular link between T-cell receptor signalling and CD4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0282818bdb277e3211a98acd91c48fc
https://pubmed.ncbi.nlm.nih.gov/25399562

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Nuclear location of tumor suppressor protein maspin inhibits proliferation of breast cancer cells without affecting proliferation of normal epithelial cells

Autor: Mirosław Sopel, Ryszard Rzepecki, Katarzyna Wachowicz, Magdalena Machowska

Publikováno v: BMC Cancer

Background Maspin, which is classified as a tumor suppressor protein, is downregulated in many types of cancer. Several studies have suggested potential anti-proliferative activity of maspin as well as sensitizing activity of maspin for therapeutic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9c8c190bb9be3bfc045636f2277f52
https://doi.org/10.1186/1471-2407-14-142

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In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors

Autor: Günther Böck, Vanessa Marzola, Heidi Fiegl, Igor Theurl, Nico van Rooijen, Hanneke Evens, Wolfgang Doppler, Katarzyna Wachowicz, Piotr Tymoszuk, Marie-Helene Wasmer, Elisabeth Müller-Holzner, Sebak Datta

Publikováno v: Tymoszuk, P, Evens, H, Marzola, V, Wachowicz, K, Wasmer, M H, Datta, S, Muller-Holzner, E, Fiegl, H, Bock, G, van Rooijen, N, Theurl, I & Doppler, W 2014, ' In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors ', European Journal of Immunology, vol. 44, no. 8, pp. 2247-2262 . https://doi.org/10.1002/eji.201344304
European Journal of Immunology, 44(8), 2247-2262. Wiley-VCH Verlag

Infiltration of a neoplasm with tumor-associated macrophages (TAMs) is considered an important negative prognostic factor and is functionally associated with tumor vascularization, accelerated growth, and dissemination. However, the ontogeny and diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c57785df20e5a45e6ade0883f6622e
https://research.vumc.nl/en/publications/35ab19b7-57fe-4c5e-a75e-f39914b4baa3

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