Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Katarzyna Tomala"'
Publikováno v:
eLife, Vol 12 (2024)
The loss of a single chromosome in a diploid organism halves the dosage of many genes and is usually accompanied by a substantial decrease in fitness. We asked whether this decrease simply reflects the joint damage caused by individual gene dosage de
Externí odkaz:
https://doaj.org/article/304e28f794e3430c940527b751cbb630
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 6, Pp 1899-1911 (2017)
Over its evolutionary history, Saccharomyces cerevisiae has evolved to be well-adapted to fluctuating nutrient availability. In the presence of sufficient nutrients, yeast cells continue to proliferate, but upon starvation haploid yeast cells enter s
Externí odkaz:
https://doaj.org/article/bbe0e7a456a74cdcbb6a92843a052db9
Autor:
Marcin Plech, Katarzyna Tomala, Hanna Tutaj, Dominika Ewa Piwcewicz, J Arjan G M de Visser, Ryszard Korona
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006768 (2017)
The functional basis of genetic robustness, the ability of organisms to suppress the effects of mutations, remains incompletely understood. We exposed a set of 15 strains of Saccharomyces cerevisiae form diverse environments to increasing doses of th
Externí odkaz:
https://doaj.org/article/98d2b875449942ac9c5cd810a6b1f711
Publikováno v:
Genome Biology and Evolution
The misfolding avoidance hypothesis postulates that sequence mutations render proteins cytotoxic and therefore the higher the gene expression, the stronger the operation of selection against substitutions. This translates into prediction that relativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5479587d968882164585d3ed648f90
https://doi.org/10.1093/gbe/evaa067
https://doi.org/10.1093/gbe/evaa067
Publikováno v:
Genetics. 221(1)
Former studies have established that loss of heterozygosity can be a key driver of sequence evolution in unicellular eukaryotes and tissues of metazoans. However, little is known about whether the distribution of loss of heterozygosity events is larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1943a88c33199735b94fd587ff31b0d
https://pubmed.ncbi.nlm.nih.gov/35212738
https://pubmed.ncbi.nlm.nih.gov/35212738
Publikováno v:
Mol Biol Evol
Previous experiments with temperature-sensitive mutants of the yeast enzyme orotidine 5′-phosphate decarboxylase (encoded in gene URA3) yielded the unexpected result that reversion occurs only through exact reversal of the original mutation (Jakubo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa9ed288f785d54811ad713885cfb95
https://doi.org/10.1093/molbev/msz110
https://doi.org/10.1093/molbev/msz110
Publikováno v:
Biogerontology
Systematic collections of single-gene deletions have been invaluable in uncovering determinants of lifespan in yeast. Overexpression of a single gene does not have such a clear outcome as cancellation of its function but it can lead to a variety of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c7e718a3de46d771ed5c56ffeebb5f
https://ruj.uj.edu.pl/xmlui/handle/item/284599
https://ruj.uj.edu.pl/xmlui/handle/item/284599
Autor:
Agnieszka Marek, Katarzyna Tomala
Publikováno v:
Genome Biology and Evolution
The negative correlation between the rate of protein evolution and expression level of a gene has been recognized as a universal law of the evolutionary biology (Koonin 2011). In our study, we apply a population-based approach to systematically inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fab74ec08e42fa41d7023f1acb98f9f
http://europepmc.org/articles/PMC6250307
http://europepmc.org/articles/PMC6250307
Publikováno v:
Current Genetics
Loss of heterozygosity (LOH) in a vegetatively growing diploid cell signals irregularity of mitosis. Therefore, assays of LOH serve to discover pathways critical for proper replication and segregation of chromosomes. We screened for enhanced LOH in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58741b3264e0738637ac0080891ef341
https://pubmed.ncbi.nlm.nih.gov/30244280
https://pubmed.ncbi.nlm.nih.gov/30244280
Publikováno v:
Current genetics. 65(2)
Loss of heterozygosity (LOH) in a vegetatively growing diploid cell signals irregularity of mitosis. Therefore, assays of LOH serve to discover pathways critical for proper replication and segregation of chromosomes. We screened for enhanced LOH in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65413b73ee6238eb3cee79d393ba864f
https://pubmed.ncbi.nlm.nih.gov/30327879
https://pubmed.ncbi.nlm.nih.gov/30327879