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pro vyhledávání: '"Katarzyna Sipa"'
Autor:
Genowefa Nowak, Katarzyna Sipa, Maria Maszewska, Magdalena Janicka, Julia Kazmierczak-Baranska, Barbara Nawrot, Elzbieta Sochacka
A series of nucleobase-modified siRNA duplexes containing “rare” nucleosides, 2-thiouridine (s2U), pseudouridine (Ψ), and dihydrouridine (D), were evaluated for their thermodynamic stability and gene silencing activity. The duplexes with modifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8955e998c0a84c93a1ffc131b89512
https://europepmc.org/articles/PMC1924902/
https://europepmc.org/articles/PMC1924902/
Autor:
Barbara Nawrot, Katarzyna Sipa
Publikováno v:
Current topics in medicinal chemistry. 6(9)
Short interfering RNAs (siRNAs) are 21-23 nt long double-stranded oligoribonucleotides which in mammalian cells exhibit a potency for sequence-specific gene silencing via an RNA interference (RNAi) pathway. It has been already proven that exogenous,