The Cystic Fibrosis Upper and Lower Airway Metagenome

Autor: Katarzyna Pienkowska, Marie-Madlen Pust, Margaux Gessner, Svenja Gaedcke, Ajith Thavarasa, Ilona Rosenboom, Patricia Morán Losada, Rebecca Minso, Christin Arnold, Silke Hedtfeld, Marie Dorda, Lutz Wiehlmann, Jochen G. Mainz, Jens Klockgether, Burkhard Tümmler

Publikováno v: Microbiology Spectrum. 11

Cystic fibrosis (CF) is the most common life-limiting monogenetic disease in European populations and is caused by mutations in the CFTR gene. Chronic airway infections with opportunistic pathogens are the major morbidity that determines prognosis an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3881ae6ef3f96a70b39eb1e6474790d
https://doi.org/10.1128/spectrum.03633-22

Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder

Autor: Judith J.M. Jans, Nanda M. Verhoeven-Duif, Mieke M. van Haelst, Gijs van Haaften, Glen R. Monroe, Karen Duran, Katarzyna Pienkowska, Holger Taschenberger, Ron van Empelen, Timothy A. Ryan, Peter M. van Hasselt, Heleen C. Van Teeseling, Francesco Michelassi, Nathaniel Calloway, Gepke Visser, Noa Lipstein, Inge Cuppen, Jeremy S. Dittman, Olaf Jahn, Annemieke M. V. Evelein, Nils Brose, Jeong-Seop Rhee, Jacob A. S. Vorstman, Sven Thoms

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, 127(3), 1005-1018. The American Society for Clinical Investigation
Journal of clinical investigation, 127(3), 1005-1018. The American Society for Clinical Investigation
Journal of Clinical Investigation, 127(3), 1005. The American Society for Clinical Investigation
Lipstein, N, Verhoeven-Duif, N M, Michelassi, F E, Calloway, N, Van Hasselt, P M, Pienkowska, K, Van Haaften, G, Van Haelst, M M, Van Empelen, R, Cuppen, I, Van Teeseling, H C, Evelein, A M V, Vorstman, J A, Thoms, S, Jahn, O, Duran, K J, Monroe, G R, Ryan, T A, Taschenberger, H, Dittman, J S, Rhee, J S, Visser, G, Jans, J J & Brose, N 2017, ' Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder ', Journal of Clinical Investigation, vol. 127, no. 3, pp. 1005-1018 . https://doi.org/10.1172/JCI90259
The Journal of Clinical Investigation

Munc13 proteins are essential regulators of neurotransmitter release at nerve cell synapses. They mediate the priming step that renders synaptic vesicles fusion-competent, and their genetic elimination causes a complete block of synaptic transmission

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b041988f891359914dc395bd5339bc
https://doi.org/10.1172/jci90259

Airway microbial metagenomics

Autor: Lutz Wiehlmann, Burkhard Tümmler, Katarzyna Pienkowska

Publikováno v: Microbes and infection. 20(9-10)

High-throughput untargeted metagenome sequencing provides information about the composition of the microbial communities of viruses, bacteria, archaea and unicellular eukaryotes in the habitat of interest. This review outlines the sampling, processin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0d381398c82289c60b043826efd219
https://pubmed.ncbi.nlm.nih.gov/29287982

Functional and bioinformatics analysis of two Campylobacter jejuni homologs of the thiol-disulfide oxidoreductase, DsbA.

Autor: Anna D Grabowska, Ewa Wywiał, Stanislaw Dunin-Horkawicz, Anna M Łasica, Marc M S M Wösten, Anna Nagy-Staroń, Renata Godlewska, Katarzyna Bocian-Ostrzycka, Katarzyna Pieńkowska, Paweł Łaniewski, Janusz M Bujnicki, Jos P M van Putten, E Katarzyna Jagusztyn-Krynicka

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e106247 (2014)

BackgroundBacterial Dsb enzymes are involved in the oxidative folding of many proteins, through the formation of disulfide bonds between their cysteine residues. The Dsb protein network has been well characterized in cells of the model microorganism

Externí odkaz: https://doaj.org/article/609ae1e86bf142ebae9cc4a71fdcee8b