Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Katarzyna M. Zoltowska"'
Autor:
Frank Raven, Joseph F. Ward, Katarzyna M. Zoltowska, Yu Wan, Enjana Bylykbashi, Sean J. Miller, Xunuo Shen, Se Hoon Choi, Kevin D. Rynearson, Oksana Berezovska, Steven L. Wagner, Rudolph E. Tanzi, Can Zhang
Publikováno v:
EBioMedicine, Vol 24, Iss C, Pp 93-101 (2017)
A central pathogenic event of Alzheimer's disease (AD) is the accumulation of the Aβ42 peptide, which is generated from amyloid-β precursor protein (APP) via cleavages by β- and γ-secretase. We have developed a class of soluble 2-aminothiazole γ
Externí odkaz:
https://doaj.org/article/8a8ad0d1c493496387f9e9c4027a02a7
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226368 (2019)
It has been revealed that β-amyloid (Aβ) is generated and released from the presynaptic terminals in activity-dependent manner. However, molecules modulating the presynaptic Aβ generation remain elusive. Here we test the hypothesis that Synapsin 1
Externí odkaz:
https://doaj.org/article/1f425d3733cc405c8b4b7712d44d3755
Autor:
Masato Maesako, Jana Horlacher, Katarzyna M Zoltowska, Ksenia V Kastanenka, Eleanna Kara, Sarah Svirsky, Laura J Keller, Xuejing Li, Bradley T Hyman, Brian J Bacskai, Oksana Berezovska
Publikováno v:
eLife, Vol 6 (2017)
The high levels of serine (S) and threonine (T) residues within the Presenilin 1 (PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/γ-secretase can be modulated by its ‘phosphorylated’ and ‘dep
Externí odkaz:
https://doaj.org/article/c7a97664d2b94297b5a3d16d9ec32dbe